Butcher, Kate Wang, Zhipeng Kurusamy, Sathishkumar Zhang, Zaixing Morris, Mark R Najlah, Mohammad McConville, Christopher Kannappan, Vinodh Wang, Weiguang
Published in
Biomolecules
Cancer stem cells (CSCs) play a key role in non-small cell lung cancer (NSCLC) chemoresistance and metastasis. In this study, we used two NSCLC cell lines to investigate the regulating effect of hypoxia in the induction and maintenance of CSC traits. Our study demonstrated hypoxia-induced stemness and chemoresistance at levels comparable to those i...
Shen, Lydia Dettmer, Ulf
Published in
Biomolecules
The maintenance of healthy mitochondria is essential for neuronal survival and relies upon mitochondrial quality control pathways involved in mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial autophagy (mitophagy). Mitochondrial dysfunction is critically implicated in Parkinson's disease (PD), a brain disorder characterized by the...
Kawaguchi, Satoshi Sepúlveda, Marisa N Teoh, Jian-Peng Hayasaka, Taiki Moukette, Bruno Aonuma, Tatsuya Roh, Hyun Cheol Madhur, Meena S Kim, Il-Man
Published in
Biomolecules
MicroRNA (miR: small noncoding RNA)-150 is evolutionarily conserved and is downregulated in patients with diverse forms of heart failure (HF) and in multiple mouse models of HF. Moreover, miR-150 is markedly correlated with the outcome of patients with HF. We previously reported that systemic or cardiomyocyte-derived miR-150 in mice elicited myocar...
Desidério, Chamberttan Souza Flávio-Reis, Victor Hugo Palhares Pessoa-Gonçalves, Yago Marcos Tiveron, Rafael Destro Rosa Sales-Campos, Helioswilton Felice, Andrei Giacchetto Soares, Siomar de Castro Guillermo-Ferreira, Rhainer Rodrigues, Wellington Francisco Oliveira, Carlo José Freire
...
Published in
Biomolecules
Ticks have coevolved with their hosts over millions of years, developing the ability to evade hemostatic, inflammatory, and immunological responses. Salivary molecules from these vectors bind to cytokines, chemokines, antibodies, complement system proteins, vasodilators, and molecules involved in coagulation and platelet aggregation, among others, ...
Januskevicius, Andrius Vasyle, Egle Rimkunas, Airidas Palacionyte, Jolita Kalinauskaite-Zukauske, Virginija Malakauskas, Kestutis
Published in
Biomolecules
Eosinophils are central inflammatory cells in asthma; however, a portion of patients with chronic obstructive pulmonary disease (COPD) have blood or sputum eosinophilia, a condition termed eosinophilic COPD (eCOPD), which may contribute to the progression of the disease. We hypothesize that eosinophilic inflammation in eCOPD patients is related to ...
Cardenas, Reinier Fernandez-Silva, Arline Ramirez-Bello, Vanesa Amero, Carlos
Published in
Biomolecules
Cataracts are diseases characterized by the opacity of the ocular lens and the subsequent deterioration of vision. Metal ions are one of the factors that have been reported to induce crystallin aggregation. For HγS crystallin, several equivalent ratios of Cu(II) promote protein aggregation. However, reports on zinc are contradictory. To characteriz...
Zhao, Yucui Zhu, Shixiao Dong, Yingling Xie, Tian Chai, Zhiqiang Gao, Xiumei Dai, Yongna Wang, Xiaoying
Published in
Biomolecules
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder (FGID) characterized by chronic or recurrent gastrointestinal symptoms without organic changes, and it is also a common disorder of gut-brain interaction (DGBIs).. The symptoms of IBS not only affect the quality of life for individual patients but also place a significant burd...
Pilat, Dominika Paumier, Jean-Michel Louis, Laurence Manrique, Christine García-González, Laura Stephan, Delphine Bernard, Anne Pardossi-Piquard, Raphaëlle Checler, Frédéric Khrestchatisky, Michel
...
Published in
Biomolecules
We previously reported that membrane-type 5-matrix metalloproteinase (MT5-MMP) deficiency not only reduces pathological hallmarks of Alzheimer's disease (AD) in 5xFAD (Tg) mice in vivo but also impairs interleukin-1 beta (IL-1β)-mediated neuroinflammation and Aβ production in primary Tg immature neural cell cultures after 11 days in vitro. We now i...
Tsioulos, Georgios Vallianou, Natalia G Skourtis, Alexandros Dalamaga, Maria Kotsi, Evangelia Kargioti, Sofia Adamidis, Nikolaos Karampela, Irene Mourouzis, Iordanis Kounatidis, Dimitris
...
Published in
Biomolecules
Cardiovascular disease (CVD) remains a leading global health concern, with atherosclerosis being its principal cause. Standard CVD treatments primarily focus on mitigating cardiovascular (CV) risk factors through lifestyle changes and cholesterol-lowering therapies. As atherosclerosis is marked by chronic arterial inflammation, the innate and adapt...
Gu, Ruonan Wang, Jerry Morin, Julianne Lu, Aizhu Liang, Wenbin
Published in
Biomolecules
Wnt/β-catenin signaling has been shown to regulate gene expressions in cardiomyocytes. However, it is not known if this effect is dependent on the sex of cells or the glucose level in the culture medium. In the present study, ventricular myocytes were prepared from male and female neonatal rats and maintained in either a glucose-rich (25 mM) medium...