Ye, Hong Liu, Xiu-Juan Hui, Yan Liang, Yang-Huan Li, Cai-Hong Wan, Qiong
Published in
Molecular therapy. Nucleic acids
Polycystic ovary syndrome (PCOS), characterized by the dysfunction of endocrine metabolism, is a common disease among women. Insulin (INS) resistance (IR) is considered as an obstruction to effective PCOS treatment. Here, we aimed to explore the mechanism by which microRNA-222 (miR-222) affects IR in PCOS via Pten. Quantitative reverse transcriptio...
Jiang, Jie Song, Bowen Tang, Yujiao Chen, Kunqi Wei, Zhen Meng, Jia
Published in
Molecular therapy. Nucleic acids
As one of the widely occurring RNA modifications, 5-methyluridine (m5U) has recently been shown to play critical roles in various biological functions and disease pathogenesis, such as under stress response and during breast cancer development. Precise identification of m5U sites on RNA is vital for the understanding of the regulatory mechanisms of...
Chen, Wanghao Wang, Hong Feng, Jia Chen, Lukui
Published in
Molecular therapy. Nucleic acids
Circular RNAs (circRNAs) are expressed at high levels in the brain and are involved in various central nervous system diseases. However, the potential role of circRNAs in ischemic stroke-associated neuronal injury remains largely unknown. Herein, we uncovered the function and underlying mechanism of the circRNA UCK2 (circUCK2) in ischemia stroke. T...
Zhu, Ke Zhou, Sijing Xu, Aiqun Sun, Li Li, Min Jiang, Huihui Zhang, Binbin Zeng, Daxiong Fei, Guanghe Wang, Ran
...
Published in
Molecular therapy. Nucleic acids
The changes of microbiota in lungs could change interleukin-17a (IL-17a) expression by altering microRNAs (miRNAs) profile, thus contributing to the pathogenesis of chronic obstructive pulmonary disease (COPD). In this study, we aimed to study molecular mechanisms' underlying effect of microbiota imbalance on COPD deterioration. Real-time polymeras...
Ma, Cui Gu, Rui Wang, Xiaoying He, Siyu Bai, June Zhang, Lixin Zhang, Junting Li, Qian Qu, Lihui Xin, Wei
...
Published in
Molecular therapy. Nucleic acids
Emerging evidence has suggested that circular RNAs (circRNAs) are involved in multiple physiological processes and participate in a variety of human diseases. However, the underlying biological function of circRNAs in pulmonary hypertension (PH) is still ambiguous. Herein, we investigated the implication and regulatory effect of a typical circRNA, ...
Saikishore, Ramanathan Velmurugan, Palanivel Ranjithkumar, Dhandapani Latha, Ragunathan Sathiamoorthi, Thangavelu Arun, Ashokbabu Ravi, Arumugam Veera Sivakumar, Subpiramaniyam
Published in
Molecular therapy. Nucleic acids
Oral squamous cell carcinoma (OSCC) is a highly recurrent form of cancer arising from the oral epithelium, which is the result of mutational change due to etiological factors such as tobacco, smoking, chewing of areca nuts, and alcohol consumption. OSCC occurrence has been observed to be prevalent in different regions of Pacific countries and in mo...
Manavalan, Balachandran Hasan, Md Mehedi Basith, Shaherin Gosu, Vijayakumar Shin, Tae-Hwan Lee, Gwang
Published in
Molecular therapy. Nucleic acids
DNA N 4-methylcytosine (4mC) is a crucial epigenetic modification involved in various biological processes. Accurate genome-wide identification of these sites is critical for improving our understanding of their biological functions and mechanisms. As experimental methods for 4mC identification are tedious, expensive, and labor-intensive, several m...
Zuo, Tongkun Tang, Qing Zhang, Xiangcheng Shang, Futai
Published in
Molecular therapy. Nucleic acids
Mitochondrial dysfunction and chemokine production have been reported to be involved in the pathogenesis of sepsis. Our initial bioinformatics analysis identified differentially expressed TLR2 in sepsis and the upstream regulatory microRNA-410-3p (miR-410-3p). Hence, the current study was performed to characterize the potential mechanism by which m...
Liu, Yihao Wang, Jie Zhou, Xiaomin Cao, Haigang Zhang, Xiaoyu Huang, Kuilong Li, Xiao Yang, Gongshe Shi, Xin'e
Published in
Molecular therapy. Nucleic acids
Skeletal muscle is an important metabolic organ of the body, and impaired skeletal muscle differentiation can result in a wide range of metabolic diseases. It has been shown that microRNAs (miRNAs) play an important role in skeletal muscle differentiation. The aim of this study was to investigate the role of mmu-miR-324-5p in the differentiation of...
Bhaduri, Utsa Merla, Giuseppe
Published in
Molecular therapy. Nucleic acids
The human tripartite motif containing protein 8 (TRIM8), a member of TRIM family proteins, is known to play a dual role as both tumor suppressor and oncogene, and to function at the crosstalk of cancer and innate immunity. In this review, in addition to accumulating recent corroborations that endorse this dual character of TRIM8, we appraise the ga...
