Xia, Qiaoxi Du, Zepeng Chen, Mantong Zhou, Xiao Bai, Wenjing Zheng, Xiaoqi Lin, Ling Zhao, Yan Ding, Jiyu Wu, Zhisheng
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Published in
Molecular oncology
During malignant tumour development, the extracellular matrix (ECM) is usually abnormally regulated. Dysregulated expression of lysyl oxidase-like 2 (LOXL2), matrix metalloproteinase 9 (MMP9) and lipocalin 2 (LCN2) are associated with ECM remodelling. In this study, protein-protein interaction assays indicated that LCN2 and LOXL2 interactions and L...
Bayliss, Richard Sarnowska, Elżbieta Yeoh, Sharon Sampson, Josephina
Published in
Molecular oncology
Immune checkpoint inhibitors (ICIs) are utilised in treating non-small cell lung cancer (NSCLC) by enhancing the immune response against cancer cells. However, they are not effective against cancers with certain genetic alterations. A recent study by Mota et al. focussed on understanding why ALK+ NSCLC cancers are immune cold and making them more r...
Blasquez, Lucas Bouzinba-Segard, Haniaa Bourdoulous, Sandrine Faure, Camille
Published in
Molecular oncology
Human epidermal growth factor receptor 2 (ErbB2/HER2) is a tyrosine kinase receptor that is overexpressed in 25% of primary human breast cancers, as well as in multiple other cancers. HER2-targeted therapies improved progression-free and overall survival in patients with HER2+ breast cancers. However, associated resistance mechanisms and toxicity h...
Egelberg, Moa De Marchi, Tommaso Pekar, Gyula Tran, Lena Bendahl, Pär-Ola Tullberg, Axel Stenmark Holmberg, Erik Karlsson, Per Farnebo, Marianne Killander, Fredrika
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Published in
Molecular oncology
Downregulation of the DNA repair protein WD40-encoding RNA antisense to p53 (WRAP53) has been associated with radiotherapy resistance and reduced cancer survival. The aim of this study was to evaluate WRAP53 protein and RNA levels as prognostic and predictive markers in the SweBCG91RT trial, in which breast cancer patients were randomized for posto...
Palmiero, Miriam Cantarosso, Isabel di Blasio, Laura Monica, Valentina Peracino, Barbara Primo, Luca Puliafito, Alberto
Published in
Molecular oncology
Metastasisation occurs through the acquisition of invasive and survival capabilities that allow tumour cells to colonise distant sites. While the role of multicellular aggregates in cancer dissemination is acknowledged, the mechanisms that drive the formation of multiclonal cell aggregates are not fully elucidated. Here, we show that cancer cells o...
Rosenberg, Shai Ben Cohen, Gil Kato, Shumei Okamura, Ryosuke Lippman, Scott M Kurzrock, Razelle
Published in
Molecular oncology
Genomic analysis, performed on tumoral tissue DNA and on circulating tumor DNA (ctDNA) from blood, is the cornerstone of precision cancer medicine. Herein, we characterized the clinical prognostic implications of the concordance of alterations in major cancer genes between tissue- and blood-derived DNA in a pan-cancer cohort. The molecular profiles...
Huang, Jin Zhao, Guofeng Peng, Qiu Yi, Xin Ji, Liyan Li, Jing Li, Pansong Guan, Yanfang Ge, Jie Chen, Ling
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Published in
Molecular oncology
The molecular landscape and the intratumor heterogeneity (ITH) architecture of gastric linitis plastica (LP) are poorly understood. We performed whole-exome sequencing (WES) and T-cell receptor (TCR) sequencing on 40 tumor regions from four LP patients. The landscape and ITH at the genomic and immunological levels in LP tumors were compared with mu...
Manicardi, Veronica Gugnoni, Mila Sauta, Elisabetta Donati, Benedetta Vitale, Emanuele Torricelli, Federica Manzotti, Gloria Piana, Simonetta Longo, Caterina Ghini, Francesco
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Published in
Molecular oncology
Mortality from vmelanoma is associated with metastatic disease, but the mechanisms leading to spreading of the cancer cells remain obscure. Spatial profiling revealed that melanoma is characterized by a high degree of heterogeneity, which is established by the ability of melanoma cells to switch between different phenotypical stages. This plasticit...
Qian, Yu Zhang, Xiang Mao, Shihui Wei, Wenwen Lin, Xiangjie Ling, Qing Ye, Wenle Li, Fenglin Pan, Jiajia Zhou, Yutong
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Published in
Molecular oncology
Bromodomain-containing protein 4 (BRD4) inhibitors have been clinically developed to treat acute myeloid leukemia (AML), but their application is limited by the possibility of drug resistance, which is reportedly associated with the activation of the WNT/β-catenin pathway. Meanwhile, homoharringtonine (HHT), a classic antileukemia drug, possibly in...
Wang, Fanchen Xu, Xiaolin Li, Xin Yuan, Jia Gao, Xuzhu Wang, Chenglong Guan, Wencai Xu, Guoxiong
Published in
Molecular oncology
Transcription factors (TFs) are key players in the regulation of gene transcription in mammalian cells. Although high-throughput screening can be used to identify differentially expressed genes between comparable groups, the precision of the corresponding datasets is far from optimal. Here, we establish Target Finder of Transcription Factor (TFoTF)...
