Sun, Zengpeng Tan, Zhiguo Peng, Chuang Yi, Weimin
Published in
Molecular medicine reports
Following the publication of the above article, the authors have realized that the Funding section of the Declarations on p. 7 was written incorrectly: The text here should have appeared as follows: 'This work was supported by the Research Fund Subsidy Project of Hunan Provincial Committee on Health Commission (grant no. 20200179) and Xiang Wei Med...
Zhou, Yun Sha, Zhenghong Yang, Yong Wu, Shuimei Chen, Hong
Published in
Molecular medicine reports
Gastric cancer is a serious malignant tumor. Despite progression in gastric cancer research in recent years, the specific molecular mechanism underlying the pathogenesis of the disease is not completely understood. Long non‑coding RNA (lncRNA) nuclear paraspeckle assembly transcript 1 (NEAT1) affects the proliferation and metastasis of multiple typ...
Meng, Lanqing Ma, Huixia Meng, Jinni Li, Tingting Zhu, Yafei Zhao, Qipeng
Published in
Molecular medicine reports
The present study investigated the effect of costunolide (CT), a compound extracted from Aucklandia lappa Decne, to attenuate oxygen‑glucose deprivation/reperfusion (OGD/R)‑induced mitochondrial‑mediated apoptosis in PC12 cells. The present study used molecular docking technology to detect the binding of CT with mitochondrial apoptotic protein targ...
Shen, Shuzhan Shao, Minhua Keyal, Uma Wang, Xiuli Li, Ming Zhang, Guolong
Published in
Molecular medicine reports
Hereditary leukonychia (HL) is a rare nail dystrophy disease, and several different clinical manifestations and mutations in the phospholipase C δ 1 (PLCD1) gene have been reported. The present study reports on one Chinese family and one sporadic case of with HL. The family members exhibited an autosomal dominant pattern of inheritance with the inv...
Cheng, Rui Liu, Xiaolong Wang, Zheng Tang, Kunlong
Published in
Molecular medicine reports
ABT‑737 is a recently reported inhibitor of members of the Bcl‑2 family of apoptosis regulators. However, to the best of our knowledge, its necroptosis‑inducing function in bladder cancer has not yet been researched. Thus, the present study aimed to investigate whether this Bcl‑2 family inhibitor can induce both apoptosis and necroptosis of urothel...
Zhao, Tianyi Meng, Wenjing Chin, Yenlie Gao, Lili Yang, Xiyue Sun, Shuangyu Pan, Xingfang He, Lihong
Published in
Molecular medicine reports
Breast cancer is the most common cancer in women and is one of the three most common malignancies worldwide. Serum microRNAs (miRNAs/miRs) are ideal biomarkers for tumor diagnosis and prognosis due to their specific biological characteristics. In several different types of cancer, miRNAs are associated with cell migration and invasion. In the prese...
Jiang, Feiya Li, Sha Jiang, Yu Chen, Zhuo Wang, Tongtong Liu, Wen
Published in
Molecular medicine reports
Paraquat (PQ) is a widely used herbicide that is severely toxic to humans and animals. Pulmonary fibrosis is a disorder that can result from PQ poisoning. Fluorofenidone (AKF‑PD) is a novel small molecule pyridone drug with a widespread and clear anti‑organ fibrosis effect; however, its mechanism of action on PQ poisoning‑induced pulmonary fibrosis...
Chen, Ruijuan Chen, Wenli Huang, Xiaoling Rui, Qinglin
Published in
Molecular medicine reports
The purpose of the present study was to evaluate whether tanshinone IIA (TIIA) could treat cardiac dysfunction and fibrosis in heart failure (HF) by inhibiting oxidative stress. An HF model was induced by ligation of the left anterior descending artery to cause ischemia myocardial infarction (MI) in Sprague‑Dawley rats. Cardiac fibrosis was evaluat...
Bai, Wenlou Huo, Tiantian Chen, Xuefeng Song, Xuelian Meng, Cunliang Dang, Yi Rong, Chunli Dou, Liwen Qi, Xiaoyong
Published in
Molecular medicine reports
The therapeutic effect of sacubitril/valsartan (S/V) on heart failure has been confirmed, while its role in atherosclerosis remains largely unexplored. The present study aimed to investigate the effects of S/V on the expression of metastasis‑associated lung adenocarcinoma transcript 1 (MALAT1), inflammation and apoptosis in human umbilical vein end...
Sheng, Shao-Qin Yu, Lei-Yuan Zhou, Xian-Wei Pan, Hong-Yi Hu, Feng-Ying Liu, Jia-Li
Published in
Molecular medicine reports
Cervical cancer is a common public health issue with high morbidity worldwide. Paeonol (Pae) has been recognized as a traditional Chinese medicine used for the treatment of various cancer types. However, whether Pae could exert a protective effect on cervical cancer remains to be investigated. The aim of the present study was to explore the role of...
