Liu, Shukun Yan, Wenxin Lv, Qi Yang, Ling Miao, Yumeng Hu, Yuxiao Wei, Zhifeng
Published in
Molecular immunology
Aryl hydrocarbon receptor (AhR) plays an important role in the occurrence and development of ulcerative colitis (UC). In this study, the effect and mechanism of 3, 3'-diindolylmethane (DIM), the classical AhR agonist, on UC was investigated from the angle of recovering the balance of Th17/Treg. The in vivo colitis model was established in mice by u...
Gao, Weiqin Lei, Yunxuan Guo, Xin Luo, Yanping Zhang, Zhenghua Xi, Yebin Wang, Weifeng Xia, Wenjie Wang, Zhaojun Niu, Xiaoyin
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Published in
Molecular immunology
Psoriatic arthritis (PsA) is a disease that transformed from psoriasis (PsO), and its underlying mechanisms are still not fully understood. Overactivation of the immune system is a key factor driving inflammatory diseases. Our goal is to define the unbalanced subsets of peripheral blood CD4 +T cells between PsO and PsA patients. Blood samples from ...
Xiao, Ziqiu Zhang, Yue She, Yawei Yuan, Guohua Yang, Guobin
Published in
Molecular immunology
Pulpitis is a chronic inflammatory process that greatly affects the physical, mental health and life quality of patients. Human dental pulp cells (hDPCs) are essential components of dental pulp tissue and play a significant role in pulpitis. Lipopolysaccharide (LPS) is an initiator of pulpitis and can induce the production of inflammatory cytokines...
Singh, Rajan Anand, Anshul Mahapatra, Baishakhi Saini, Shashi Singh, Abhishek Singh, Samer Kumar, Vinod Das, Pradeep Singh, Sangram Singh, Rakesh K
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Published in
Molecular immunology
One of the major reasons behind the limited success of vaccine candidates against all forms of leishmaniasis is the inability of parasitic antigens to induce robust cell-mediated immunity and immunological memory. Here we find, for the first time, that the adjuvantation of whole-killed Leishmania vaccine (Leishvacc) with anti-CD200 and anti-CD300a ...
Degn, Laura Lind Throne Bech, Ditte Christiansen, Gunna Birkelund, Svend
Published in
Molecular immunology
Chlamydia trachomatis is the leading cause of sexually transmitted diseases causing frequent, long-lasting, and often asymptomatic recurrent infections resulting in severe reproductive complications. C. trachomatis is an intracellular Gram-negative bacterium with a biphasic developmental cycle in which extracellular, infectious elementary bodies (E...
Rodríguez-Obediente, Kewin Yepes-Pérez, Yoelis Benavides-Ortiz, Daniel Díaz-Arévalo, Diana Reyes, César Arévalo-Pinzón, Gabriela Patarroyo, Manuel Alfonso
Published in
Molecular immunology
Plasmodium vivax's biological complexity has restricted in vitro culture development for characterising antigens involved in erythrocyte invasion and their immunological relevance. The murine model is proposed as a suitable alternative in the search for therapeutic candidates since Plasmodium yoelii uses homologous proteins for its invasion. The AM...
You, Tingyu Li, Yu Li, Bowen Wu, Shuai Jiang, Xiangfu Fu, Dongdong Xin, Jiao Huang, Yan Jin, Lei Hu, Chengmu
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Published in
Molecular immunology
Acetaminophen (APAP) is a common antipyretic and analgesic drug that can cause long-term liver damage after an overdose. Non-alcoholic fatty liver disease (NAFLD) increases susceptibility to APAP. In NAFLD, excessive accumulation of lipids leads to an abnormal increase in hypoxia-inducible factor-1α (HIF-1α). Caveolin-1 (CAV1) may protect against N...
Song, Dan Tao, Wenjing Liu, Feng Wu, Xian Bi, Haiyang Shu, Jianhong Wang, Dong Li, Xiangchen
Published in
Molecular immunology
The NLRP3 inflammasome is involved in many inflammatory diseases. Its activity must be strictly controlled to alleviate the inflammatory process. Autophagy plays a protective role in the negative regulation of NLRP3 inflammasome activation. However, the regulatory mechanism of autophagy controlling NLRP3 inflammasome activation remains to be furthe...
Davies, Anna M. Beavil, Rebecca L. Barbolov, Momchil Sandhar, Balraj S. Gould, Hannah J. Beavil, Andrew J. Sutton, Brian J. McDonnell, James M.
Published in
Molecular immunology
Antibodies of the IgD isotype remain the least well characterised of the mammalian immunoglobulin isotypes. Here we report three-dimensional structures for the Fab region of IgD, based on four different crystal structures, at resolutions of 1.45-2.75 Å. These IgD Fab crystals provide the first high-resolution views of the unique Cδ1 domain. Structu...
Li, Mei Li, Tenglong Jin, Jianliang Xie, Chunfeng Zhu, Jianyun
Published in
Molecular immunology
Human amniotic mesenchymal stem cells (hAMSCs) have attracted considerable attention as a promising regenerative therapy. Many studies reported that the conditioned medium of hAMSCs (AM-CM) exerted anti-inflammatory and immunomodulatory functions, while its underlying mechanism is poorly understood. In this study, we first confirmed that AM-CM (25%...
