Origins of the Field of Molecular Endocrinology: A Personal Perspective.
Published in Molecular endocrinology (Baltimore, Md.)
Published in Molecular endocrinology (Baltimore, Md.)
Published in Molecular endocrinology (Baltimore, Md.)
Comparison of 11 human nuclear receptor amino acid sequences revealed a conserved phosphorylation motif within their DNA-binding domains as an intramolecular signal that regulates proteolytic degradation. Nuclear receptors use this signal to either degrade or proscribe degradation through either the proteasome or nonproteasome pathways. A phosphomi...
Published in Molecular endocrinology (Baltimore, Md.)
Published in Molecular endocrinology (Baltimore, Md.)
Published in Molecular endocrinology (Baltimore, Md.)
Published in Molecular endocrinology (Baltimore, Md.)
Peptidylarginine deiminase (PAD) enzymes convert histone tail arginine residues to citrulline resulting in chromatin decondensation. Our previous work found that PAD isoforms are expressed in female reproductive tissues in an estrous cycle-dependent fashion, but their role in the anterior pituitary gland is unknown. Thus, we investigated PAD expres...
Published in Molecular endocrinology (Baltimore, Md.)
Published in Molecular endocrinology (Baltimore, Md.)
Published in Molecular endocrinology (Baltimore, Md.)
Although many tissues express estrogen receptor (ER)α, most studies focus on breast cancer where ERα occupies just a small fraction of its total repertoire of potential DNA-binding sites, based on sequence. This raises the question: Can ERα occupy these other potential binding sites in a different context? Ligands, splice variants, posttranslationa...
Published in Molecular endocrinology (Baltimore, Md.)
Circadian rhythm regulates multiple metabolic processes and in turn is readily entrained by feeding-fasting cycles. However, the molecular mechanisms by which the peripheral clock senses nutrition availability remain largely unknown. Bile acids are under circadian control and also increase postprandially, serving as regulators of the fed state in t...