Hashiguchi, Takuyu Arakawa, Shingo Takahashi, Shogo Gonzalez, Frank J Sueyoshi, Tatsuya Negishi, Masahiko
Published in
Molecular endocrinology (Baltimore, Md.)
Comparison of 11 human nuclear receptor amino acid sequences revealed a conserved phosphorylation motif within their DNA-binding domains as an intramolecular signal that regulates proteolytic degradation. Nuclear receptors use this signal to either degrade or proscribe degradation through either the proteasome or nonproteasome pathways. A phosphomi...
Khan, Shaihla A Edwards, Brian S Muth, Aaron Thompson, Paul R Cherrington, Brian D Navratil, Amy M
Published in
Molecular endocrinology (Baltimore, Md.)
Peptidylarginine deiminase (PAD) enzymes convert histone tail arginine residues to citrulline resulting in chromatin decondensation. Our previous work found that PAD isoforms are expressed in female reproductive tissues in an estrous cycle-dependent fashion, but their role in the anterior pituitary gland is unknown. Thus, we investigated PAD expres...
Schug, Thaddeus T Johnson, Anne F Birnbaum, Linda S Colborn, Theo Guillette, Louis J Jr Crews, David P Collins, Terry Soto, Ana M Vom Saal, Frederick S McLachlan, John A
...
Published in
Molecular endocrinology (Baltimore, Md.)
Within the past few decades, the concept of endocrine-disrupting chemicals (EDCs) has risen from a position of total obscurity to become a focus of dialogue, debate, and concern among scientists, physicians, regulators, and the public. The emergence and development of this field of study has not always followed a smooth path, and researchers contin...
Kraus, W Lee
Published in
Molecular endocrinology (Baltimore, Md.)
Pedraz-Cuesta, Elena Fredsted, Jacob Jensen, Helene H Bornebusch, Annika Nejsum, Lene N Kragelund, Birthe B Pedersen, Stine F
Published in
Molecular endocrinology (Baltimore, Md.)
Prolactin (PRL) and its receptor (PRLR) are implicated in breast cancer invasiveness, although their exact roles remain controversial. The Na(+)/H(+) exchanger (NHE1) plays essential roles in cancer cell motility and invasiveness, but the PRLR and NHE1 have not previously been linked. Here we show that in T47D human breast cancer cells, which expre...
Breit, Andreas Wicht, Kristina Boekhoff, Ingrid Glas, Evi Lauffer, Lisa Mückter, Harald Gudermann, Thomas
Published in
Molecular endocrinology (Baltimore, Md.)
Melanocyte-stimulating hormone (MSH)-induced activation of the cAMP-response element (CRE) via the CRE-binding protein in hypothalamic cells promotes expression of TRH and thereby restricts food intake and increases energy expenditure. Glucose also induces central anorexigenic effects by acting on hypothalamic neurons, but the underlying mechanisms...
Johannes, Jörg Braun, Doreen Kinne, Anita Rathmann, Daniel Köhrle, Josef Schweizer, Ulrich
Published in
Molecular endocrinology (Baltimore, Md.)
Monocarboxylate transporters (MCTs) belong to the SLC16 family within the major facilitator superfamily of transmembrane transporters. MCT8 is a thyroid hormone transporter mutated in the Allan-Herndon-Dudley syndrome, a severe psychomotor retardation syndrome. MCT10 is closely related to MCT8 and is known as T-type amino acid transporter. Both tra...
Yang, Xiaosong Wu, Rui Shan, Weiguang Yu, Liqing Xue, Bingzhong Shi, Hang
Published in
Molecular endocrinology (Baltimore, Md.)
Better understanding the mechanisms underlying adipogenesis may provide novel therapeutic targets in the treatment of obesity. Most studies investigating the mechanisms underlying adipogenesis focus on highly regulated transcriptional pathways; little is known about the epigenetic mechanisms in this process. Here, we determined the role of DNA meth...
Goode, Joel M Pearen, Michael A Tuong, Zewen K Wang, Shu-Ching M Oh, Tae Gyu Shao, Emily X Muscat, George E O
Published in
Molecular endocrinology (Baltimore, Md.)
Skeletal muscle remodels metabolic capacity, contractile and exercise phenotype in response to physiological demands. This adaptive remodeling response to physical activity can ameliorate/prevent diseases associated with poor diet and lifestyle. Our previous work demonstrated that skeletal muscle-specific transgenic expression of the neuron-derived...
Mo, Li Shen, Jing Liu, Qinhui Zhang, Yuwei Kuang, Jiangying Pu, Shiyun Cheng, Shihai Zou, Min Jiang, Wei Jiang, Changtao
...
Published in
Molecular endocrinology (Baltimore, Md.)
Irisin, a hormone proteolytically processed from fibronectin type III domain-containing protein 5 (FNDC5), has been reported to induce the browning of sc adipocytes by increasing the level of uncoupling protein 1. In this study, we showed that activation of the nuclear receptor constitutive androstane receptor induced FNDC5 mRNA expression in the l...
