Seifi, Razieh Ayat, Hoda Ahadi, Ali Mohammad
Published in
Molecular biology research communications
Scorpion venom contains various toxin peptides with pharmacological and biological properties. Scorpion toxins specifically interact with membrane ion channels which play key roles in progression of cancer. Therefore, scorpion toxins have received special attention for targeting cancer cells. Two new toxins MeICT and IMe-AGAP, isolated from Iranian...
Salehi, Zahra Amirahmadi, Atefe Rezaei, Arezou Farrokh, Parisa Ghasemian, Javad
Published in
Molecular biology research communications
Extracting high-yield, high-quality DNA from plant samples is challenging due to the presence of the cell wall, pigments, and some secondary metabolites. The main CTAB method, two of its modified protocols (beta-mercaptoethanol or ammonium acetate were eliminated), the modified Murray and Thompson method, and the Gene All kit were statistically com...
Zarghampoor, Farzaneh Valibeigi, Behnaz Behzad-Behbahani, Abbas
Published in
Molecular biology research communications
Despite various treatment options available for colorectal cancer, the survival rates for patients remain low. This study investigated the effects of hyperthermia and Ibuprofen on human colorectal adenocarcinoma cells (HT-29) viability, proliferation, and gene expression related to tumor suppression, Wnt signaling pathways, proliferation, and apopt...
Kamalzade, Zahra Hoveizi, Elham Fereidoonnezhad, Masood
Published in
Molecular biology research communications
Toxicity and autophagy effects of a new complex of platinum II (CPC) were evaluated on HeLa cells cultured on a PCL/gelatin electrospinning scaffold. HeLa cells were treated with CPC on the first, third, and fifth days and the concentration of IC50 was determined. The autophagic and apoptotic effects of CPC were examined by MTT assay, Acridine Oran...
Saify, Khyber
Published in
Molecular biology research communications
Human leukocyte antigen-DQB1 (HLA-DQB1, OMIM: 604305) is the human major histocompatibility complex (MHC) system. HLA genes are classified into three classes (I, II, and III). The HLA-DQB1 belongs to class II, is mainly involved in the actions of the human immune system and plays a fundamental role in donor-recipient matching in transplantation and...
Soman, Smitha Ram, Siya
Published in
Molecular biology research communications
tRNA modifications play a significant role in the structural stability as well as translational fidelity in all organisms from bacteria to humans. They also play a major role in bacterial physiology by regulating translation in response to various environmental stresses. Modifications coming at the anticodon-stem loop (ASL) are particularly importa...
Heidary, Fatemeh Tourani, Mehdi Hejazi-Amiri, Fatemeh Khatami, Seyyed Hossein Jamali, Navid Taheri-Anganeh, Mortaza
Published in
Molecular biology research communications
Lung cancer is the most common type of tumor worldwide. Non-small-cell lung carcinoma (NSCLC) is considered any epithelial cell-related lung cancer, which includes more than 85% of all lung cancer cases. NSCLC is less responsive to chemotherapy than SCLC. Therefore, the need for other treatments has become more pronounced and immunotherapy has gain...
Hozhabri, Yaser Sadeghi, Asie Nazari-Robati, Mahdieh Bahri, Faegheh Salimi, Fouzieh Abolhassani, Moslem Mohammadi, Abbas
Published in
Molecular biology research communications
Aging is associated with an increase in oxidative stress, which damages organs such as the kidney. Trehalose has abundant beneficial activities including antioxidative effects. This study aimed to investigate the effects of trehalose on several antioxidant parameters of the aged kidney. Wistar rats were divided into three groups: young (4 months), ...
Khosravi, Ahmad Reza Eslami-Farouji, Atena Sultani-Ahmadzai, Atiqullah Mohsenzadeh, Sasan
Published in
Molecular biology research communications
One new tribe (Plagiolobeae), one new species (Plagioloba derakii) together with two new combinations (P. persica and P. clavata) are established within Brassicaceae based on a decisive consideration of molecular phylogenetic dataset, morphological characters, fruit septum nature, as well as seed microsculpturing features. Results distinctly justif...
Khorsand, Marjan Mostafavi-Pour, Zohreh Razban, Vahid Khajeh, Sahar Zare, Razieh
Published in
Molecular biology research communications
The epithelial-to-mesenchymal transition (EMT) is a unique process resulting in enhanced cell motility, invasiveness, and metastasis in cancer. The EMT is regulated by several transcription factors, including Snail and Slug, which exert crucial roles during cancer progression. We have studied the effects of Docetaxel as the first-line chemotherapy ...
