Ushigome, Mitsunori Shimada, Hideaki Nabeya, Yoshihiro Shiratori, Fumiaki Soda, Hiroaki Takiguchi, Nobuhiro Hoshino, Isamu Kuwajima, Akiko Kaneko, Tomoaki Funahashi, Kimihiko
...
Published in
Molecular and clinical oncology
RalA protein, a member of the Ras superfamily of small GTPases, is a tumor antigen that induces serum RalA antibodies (s-RalA-Abs). The present study explored the clinicopathological and prognostic significance of s-RalA-Abs in patients with colorectal cancer. Serum samples were obtained from 314 patients with colorectal cancer at stage 0/I (n=71),...
Gordeeva, Olga O Meshcheryakova, Lyudmila A Karseladze, Apollon I Meshcheryakova, Nadezhda A Meshcheryakov, Andrey A
Published in
Molecular and clinical oncology
Clear-cell carcinoma (CCC) of the uterus is an aggressive disease. Current international guidelines on the treatment of uterine carcinomas predominantly cover cancer with endometrioid histology, and clinicians tend to use the same approach for patients with non-endometrioid histology due to the absence of separate guidelines for these rare tumor ty...
Yamamoto, Makoto Kurata, Kazumi Asai-Sato, Mikiko Shiomi, Mayu Ueda, Yutaka Aoki, Yoichi Yoshida, Yoshio
Published in
Molecular and clinical oncology
Little is known about preoperative and intraoperative risk factors for postoperative complications in older patients with gynecological cancer. The present retrospective multi-institutional study included 173 older patients with primary gynecological cancer between January 2015 and December 2015 at four institutions. The cancer stage, medical histo...
Bai, Rui Zhao, Zhen-Qun Wang, Yu-Xin Zhao, Wei Wu, Li-Shuan Cui, Shu-Xia Guo, Shi-Bing Liang, Chen-Liang
Published in
Molecular and clinical oncology
Chordoma is a sporadic type of cancer that affects the spine and is particularly challenging to treat due to the paucity of reported cases and scientific literature. In particular, primary chordomas affecting both the sacral and thoracic vertebrae are extremely rare. We herein report a rare case of chordoma in the sacral and thoracic vertebrae with...
Özdirik, Burcin Amthauer, Holger Schatka, Imke Goretzki, Peter E Mogl, Martina T Fehrenbach, Uli Tacke, Frank Jann, Henning Roderburg, Christoph
Published in
Molecular and clinical oncology
Neuroendocrine tumors (NET) are rare and demonstrate variable clinical behavior depending on the degree of tumor differentiation. Patients with poorly differentiated tumors (NET G3) have a poor prognosis. Systemic treatment with cytotoxic chemotherapy is considered to be the treatment of choice. In patients that are refractory or intolerant to firs...
Iwatate, Yosuke Hoshino, Isamu Ishige, Fumitaka Itami, Makiko Chiba, Satoshi Arimitsu, Hidehito Yanagibashi, Hiroo Nagase, Hiroki Yokota, Hajime Takayama, Wataru
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Published in
Molecular and clinical oncology
The p16 gene, which is also known as CDKN2A, INK4A, or CDK4I, and its products that are known to be cell cycle inhibitors and tumor suppressors have been reported to be altered in various human tumor types. Altered p16 has been indicated to be correlated with negative p16 expression using immunohistochemistry (IHC). However, its association with th...
Yokota, Tomoya Shibata, Masayuki Hamauchi, Satoshi Shirasu, Hiromichi Onozawa, Yusuke Ogawa, Hirofumi Onoe, Tsuyoshi Kawakami, Takeshi Furuta, Mitsuhiro Inoue, Hiroto
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Published in
Molecular and clinical oncology
Chemoradiotherapy (CRT) with concurrent high-dose cisplatin (CDDP) is a standard treatment for locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). Docetaxel plus CDDP and 5-fluorouracil (TPF) induction chemotherapy (ICT) prior to CRT is considered for patients at high risk of distant metastases. The purpose of the current stud...
Takayama, Kanako Nakamura, Tatsuya Takada, Akinori Kato, Takahiro Sakuma, Hideo Mitsudo, Kenji Fuwa, Nobukazu Murakami, Masao
Published in
Molecular and clinical oncology
Ameloblastic carcinoma (AC) is a very rare malignant odontogenic tumor. Although surgical resection is generally performed, treatment approaches have not been established for recurrent cases. Chemotherapy and radiotherapy are positioned as adjunctive therapies, and few studies investigated definitive non-operative therapy. We present the case of a ...
Zucker, Amanda Winter, Alex Lumley, Dean Karwowski, Pawel Jung, Min-Kyung Kao, Johnny
Published in
Molecular and clinical oncology
High baseline neutrophil-to-lymphocyte ratio (NLR) has been associated with poor survival in a number of solid tumors, but has not been extensively investigated in the context of radiation oncology. Developing more robust models to predict survival would inform patient care for patients with metastatic solid tumors. The present study was undertaken...
Kato, Tomoki Matayoshi, Akira Nakasone, Toshiyuki
Published in
Molecular and clinical oncology
Aortic valve stenosis [or aortic stenosis, (AS)] is a risk factor in non-cardiac surgery. Guidelines from the European Heart Association recommended that AS treatment should be applied prior to non-cardiac surgery. Transcatheter aortic valve implantation (TAVI) is a method of minimally invasive AS treatment. The present study reports a case of tong...
