Li, Jia Li, Mingming Bai, Ling
Published in
Molecular and cellular biochemistry
The dysregulated long noncoding RNAs (lncRNAs) are associated with the pathogenesis of diabetic nephropathy (DN). LncRNA potassium voltage-gated channel subfamily Q member 1 overlapping transcript 1 (KCNQ1OT1) plays an important role in diabetes, but the role and mechanism of KCNQ1OT1 in DN are largely unknown. Serum samples were collected from 30 ...
Jiang, Hua Yin, Hong Wang, Lin Feng, Chunzhen Bai, Yang Huang, Dongzong Zhang, Qiao Liu, Hongchen Hu, Yuan
Published in
Molecular and cellular biochemistry
Although tooth loss is a known risk factor of cognitive function, whether and how the chewing-side preference (CSP) affects memory impairment still remains unclear. This study evaluates the behavior changes in mice after the loss of teeth on one side and explores the role of serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) signal pathw...
Chen, Manman Li, Lu Liu, Chuanqin Song, Lina
Published in
Molecular and cellular biochemistry
Alzheimer's disease (AD) is a public health issue worldwide. Berberine (Ber) acts as the neuroprotective role in an animal experiment of AD. MicroRNA-188 (miRNA-188) was reported to be decreased in primary hippocampal neurons of mice. However, the roles and molecular basis of Ber and miRNA-188 in the treatment of AD need to be further explored. In ...
Pei, Jingliang Sun, Xiaowei Yang, Guimao Zhang, Shuying
Published in
Molecular and cellular biochemistry
Long noncoding RNAs (lncRNAs) have been shown to be implicated in acetaminophen (APAP)-induced liver injury (AILI). We applied this study to investigate the role and functional mechanism of KCNQ1 overlapping transcript 1 (KCNQ1OT1) in AILI. The AILI model was established by APAP treatment in mice. The liver injury was preliminarily evaluated by ALT...
Uddin, Md Main Ibrahim, Mostafa M H Aryal, Dinesh Briski, Karen P
Published in
Molecular and cellular biochemistry
Hypoglycemia is a detrimental complication of rigorous management of type 1 diabetes mellitus. Moderate hypoglycemia (MH) preconditioning of male rats partially affords protection from loss of vulnerable brain neurons to severe hypoglycemia (SH). Current research investigated whether MH preconditioning exerts sex-dimorphic effects on hippocampal CA...
Fu, Chun-Hua Lai, Fang-Fang Chen, Sai Yan, Cai-Xia Zhang, Bing-Hong Fang, Cheng-Zhi Wang, Gao-Hua
Published in
Molecular and cellular biochemistry
Hypoxic-ischemic (HI) brain damage (HIBD) leads to high neonatal mortality and severe neurologic morbidity. Autophagy is involved in the pathogenesis of HIBD. This study aims to investigate the effect of long non-coding RNA colorectal neoplasia differentially expressed (CRNDE) on HIBD and to validate whether autophagy is involved in this process. A...
Han, Xu Zhu, Feifei Chen, Liang Wu, Hong Wang, Tao Chen, Keping
Published in
Molecular and cellular biochemistry
Food additives are widely used in various food products to preserve the taste, color, and other qualities. However, if they are used improperly or exceed the standard, they will cause damage to the human body. Sulfite is a commonly used food additive to prevent oxidation from deteriorating the nutrients in foods, it has been widely used as a bleach...
Wei, Wen-Ying Zhao, Qing Zhang, Wen-Zhong Wang, Mao-Jing Li, Yan Wang, Shi-Zhong Zhang, Ning
Published in
Molecular and cellular biochemistry
Secreted frizzled-related protein 2 (sFRP2) has been reported to be involved in cardiovascular diseases. However, its role in cardiac hypertrophy induced by pressure overload is still elusive. We aimed to examine the role of sFRP2 in the development of cardiac hypertrophy in vivo and in vitro. Following cardiac hypertrophy stimulated by aortic band...
Liu, Bing Qiao, Jiao Hu, Jinxiu Fan, Minghua Zhao, Yanfang Su, Hong Wang, Ziyang Yu, Qun Ma, Qiqi Li, Yanmei
...
Published in
Molecular and cellular biochemistry
Endothelial dysfunction (ED) has a high incidence in chronic kidney disease (CKD) and is identified as a precursor to cardiovascular events. Recent studies suggest that leptin may be the missing link between ED and CKD. The objective of this study was to investigate the mechanism by which leptin causes ED and the connection with leptin and indicato...
Li, Yehong Zhang, Shanshan Zhang, Cunxin Wang, Meihong
Published in
Molecular and cellular biochemistry
Ankylosing spondylitis (AS) is a progressive systemic disease characterized by chronic inflammation response of the sacroiliac joint and spine. Long non-coding RNAs (lncRNAs) are widely involved in the regulation of various diseases. However, the role of lncRNA maternally expressed gene 3 (MEG3) in the inflammatory response of AS has not been studi...
