Ferreira, Filipa P Pereira, Sofia S Costa, Madalena M Guimarães, Marta Albrechtsen, Nicolai J Wewer Holst, Jens J Nora, Mário Monteiro, Mariana P
Published in
Molecular and cellular biochemistry
Neurotensin (NT) is a gastro-intestinal hormone involved in several pathways that regulate energy and glucose homeostasis. NT was hypothesized to act in synergy with incretin hormones to potentiate its anti-diabetic effects. Additionally, circulating NT levels were shown to rise after bariatric surgery-induced weight loss. Knowledge of NT-secreting...
Tang, Xiaohu Liu, Zhiyan Ren, Jingwen Cao, Ying Xia, Shujie Sun, Zhaolin Luo, Guangheng
Published in
Molecular and cellular biochemistry
In ageing men, benign prostatic hyperplasia (BPH) is a chronic disease that leads to progressive lower urinary tract symptoms (LUTS) caused by obstruction of the bladder outlet (BOO). Patients with LUTS (such as increased frequency and urgency of urination) and complications of BOO (such as hydronephrosis and bladder stones) are at risk of serious ...
Mohamed, Asmaa S Abdel-Fattah, Dina S Abdel-Aleem, Ghada A El-Sheikh, Thanaa F Elbatch, Manal M
Published in
Molecular and cellular biochemistry
Parkinson's disease (PD) is a chronic and ongoing neurological condition. Unfortunately, as the dopaminergic terminals continue to deteriorate, the effectiveness of anti-Parkinson therapy decreases. This study aimed to examine the effects of BM-MSCs-derived exosomes in rats induced with Parkinson's disease. The goal was to determine their potential...
Noothi, Sunil K Ahmed, Mohamed Radwan Agrawal, Devendra K
Published in
Molecular and cellular biochemistry
Atherosclerotic disease of the coronary and carotid arteries is the primary global cause of significant mortality and morbidity. The chronic occlusive diseases have changed the epidemiological landscape of health problems both in developed and the developing countries. Despite the enormous benefit of advanced revascularization techniques, use of st...
Medoro, Alessandro Saso, Luciano Scapagnini, Giovanni Davinelli, Sergio
Published in
Molecular and cellular biochemistry
The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is well recognized as a critical regulator of redox, metabolic, and protein homeostasis, as well as the regulation of inflammation. An age-associated decline in NRF2 activity may allow oxidative stress to remain unmitigated and affect key features associated with the aging ...
Roux, Aurelie Winnard, Paul T Jr Van Voss, Marise Heerma Muller, Ludovic Jackson, Shelley N Hoffer, Barry Woods, Amina S Raman, Venu
Published in
Molecular and cellular biochemistry
Breast cancer brain metastasis (BCBM) has an incidence of 10-30%. It is incurable and the biological mechanisms that promote its progression remain largely undefined. Consequently, to gain insights into BCBM processes, we have developed a spontaneous mouse model of BCBM and in this study found a 20% penetrance of macro-metastatic brain lesion forma...
Seema, Bhargava Prahlad, K Sethi Anuradha, Batra Sangeeta, Choudhury Parul, Takkar Anjali, Manocha Mamta, Kankra Parul, Singla
Published in
Molecular and cellular biochemistry
Cognitive impairment is a progressive disorder that affects the ageing population. With the increase in the mean age of our population, it is becoming a public health problem. Homocysteinemia has been implicated in cognitive impairment. Whilst it is modulated by vitamins B12 and folate, it acts through MMPs 2 and 9. To assesses the relationship of ...
Zubkova, Ekaterina Semenkova, Lidiya Dudich, Elena Dudich, Igor Parfyonova, Yelena Menshikov, Mikhail
Published in
Molecular and cellular biochemistry
de María Márquez Álvarez, Corazón Gómez-Crisóstomo, Nancy Patricia De la Cruz-Hernández, Erick Natividad Zazueta, Cecilia Aguilar-Gamas, Carlos Francisco Martínez-Abundis, Eduardo
Published in
Molecular and cellular biochemistry
Obesity is a relevant health public issue and is the main factor for glucose metabolism dysregulation and diabetes progression; however, the differential role of a high-fat diet or high sugar diet consumption on glucose metabolism and insulin processing is not well understood and has been scarcely described. Our research aimed to analyze the effect...
Tan, Ya Zhao, Nan Xie, Qiaoling Xu, Ziqian Chai, Jin Zhang, Xiaoxun Li, Yan
Published in
Molecular and cellular biochemistry
Melatonin, an indole neurohormone secreted mainly by the pineal gland, has been found to be involved in a variety of liver diseases. However, the underlying mechanism by which melatonin ameliorates cholestatic liver injury is not fully understood. In this study, we investigated the mechanism by which melatonin attenuates cholestatic liver injury vi...
