Torres-Cifuentes, Diana Milena Espíritu-Gordillo, Patricia Baylón-Pacheco, Lidia Rosales-Encína, José Luis
Published in
Molecular and biochemical parasitology
The Entamoeba histolytica parasite is the causative agent of amebiasis, infecting approximately 1% of the world population and causing 100,000 deaths per year. It binds to Fibronectin (FN), activating signaling pathways regulated by kinases and phosphatases. EhLMW-PTPs genes from E. histolytica encode for Low Molecular Weight Tyrosine Phosphatases ...
Sagasti, Camila Casaravilla, Cecilia Fernández, Cecilia Fló, Martín Díaz, Álvaro
Published in
Molecular and biochemical parasitology
The genus Echinococcus of cestode parasites includes important pathogens of humans and livestock animals. Transcriptomic and genomic studies on E. granulosus and E. multilocularis uncovered striking expansion of monodomain Kunitz proteins. This expansion is accompanied by the specialization of some family members away from the ancestral protease in...
Stevanovic, Strahinja Marjanović, Djordje S Trailović, Sasa M Zdravković, Nemanja Perdih, Andrej Nikolic, Katarina
Published in
Molecular and biochemical parasitology
Parasitic infections are a widespread health problem and research of novel anthelmintic compounds is of the utmost importance. In this study we performed a virtual screening campaign by coupling ligand-based pharmacophore, homology modeling and molecular docking. The virtual screening campaign was conducted using a joined pool of the Drugbank datab...
Maudlin, Isabella E Kelly, Steve Schwede, Angela Carrington, Mark
Published in
Molecular and biochemical parasitology
The bloodstream form of Trypanosoma brucei persists in mammalian hosts through a population survival strategy depending on antigenic variation of a cell surface coat composed of the variant surface glycoprotein (VSG). The integrity of the VSG coat is essential and blocking its synthesis results in a cell division cycle arrest just prior to cytokine...
Roscoe, Scott Manni, Emad Roberts, Mikayla Ananvoranich, Sirinart
Published in
Molecular and biochemical parasitology
Two poly(A) binding proteins (PABPs) of Toxoplasma gondii, were identified and characterized. They were named TgPABPC and TgPABPN as they were found to localize in the cytoplasm and nucleus respectively. TgPABPC, which colocalizes with mRNA granules, is therefore used as a cellular marker of mRNP granules. We detected that the formation of mRNP gra...
Egarter, Saskia Santos, Jorge M Kehrer, Jessica Sattler, Julia Frischknecht, Friedrich Mair, Gunnar R
Published in
Molecular and biochemical parasitology
Substrate-dependent gliding motility is key to malaria transmission. It mediates host cell traversal, invasion and infection by Plasmodium and related apicomplexan parasites. The 110 amino acid-long cell surface protein LIMP is essential for P. berghei sporozoites where it is required for the invasion of the mosquito's salivary glands and the liver...
Santhi, Velayudhan Satheeja Ment, Dana Faigenboim, Adi Salame, Liora Soroker, Victoria Hetzroni, Amots Glazer, Itamar
Published in
Molecular and biochemical parasitology
As the larvae of the date palm pest, the red palm weevil, Rhynchophorus ferrugineus, feeds on the host tissue, they emit a distinctive sound which can be recorded outside of the infected tree. We evaluated the response of infective juveniles (IJs) of the entomopathogenic nematodes Steinernema carpocapsae to the R. ferrugineus larvae and it's sound ...
Turra, Gino L Schneider, Luzia Liedgens, Linda Deponte, Marcel
Published in
Molecular and biochemical parasitology
Leishmania parasites include important pathogens and model organisms and are even used for the production of recombinant proteins. However, functional genomics and the characterization of essential genes are often limited in Leishmania because of low-throughput technologies for gene disruption or tagging and the absence of components for RNA interf...
Liu, Dandan Wang, Feiyan Cao, Liqin Wang, Lele Su, Shijie Hou, Zhaofeng Xu, Jinjun Hu, Junjie Tao, Jianping
Published in
Molecular and biochemical parasitology
Gametocyte proteins of Eimeria spp. are essential components of the oocyst wall, and some of these proteins have been analysed to identify targets of transmission-blocking vaccines against avian coccidiosis. In the present study, a cDNA from E. necatrix gametocytes was cloned and sequenced. The cDNA is 1473 bp in length and encodes a 490-amino-acid...
Fonseca, Priscilla D M Corral, Marcelo A Cosenza-Contreras, Miguel Meisel, Dirce M C L Melo, Gessica B Antunes, Milena M S Santo, Maria C E Gryschek, Ronaldo C B Costa-Cruz, Julia M Castro-Borges, William
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Published in
Molecular and biochemical parasitology
