Leow, Chiuan Yee Willis, Charlene Leow, Chiuan Herng Hofmann, Andreas Jones, Malcolm
Published in
Molecular and biochemical parasitology
Schistosomes are parasitic blood flukes that infect approximately 250 million people worldwide. The disease known as schistosomiasis, is the second most significant tropical parasitic disease after malaria. Praziquantel is the only effective drug currently licensed for schistosomiasis and there are concerns about resistance to the drug. There has b...
Walters, Heather A Welter, Brenda H Sullivan, William J Jr Temesvari, Lesly A
Published in
Molecular and biochemical parasitology
Entamoeba histolytica is an intestinal parasite infecting over 50 million people worldwide and is the causative agent of amebic dysentery and amoebic liver abscess. In the human host, E. histolytica experiences stress brought on by nutrient deprivation and the host immune response. To be a successful parasite, E. histolytica must counter the stress...
Isah, Murtala Bindawa Goldring, J P Dean Coetzer, Theresa H T
Published in
Molecular and biochemical parasitology
Copper is an essential component of cuproproteins but can be toxic to cells, therefore copper metabolism is very carefully regulated within cells. To gain insight into trypanosome copper metabolism, Trypanosoma spp. genomic databases were screened for the presence of copper-containing and -transporting proteins. Among other genes encoding copper-bi...
Carvalho-Kelly, Luiz Fernando Gomes-Vieira, André Luiz Paes-Vieira, Lisvane da Silva, Amanda Durval Zeferino Meyer-Fernandes, José Roberto
Published in
Molecular and biochemical parasitology
Here we characterize a high-affinity Pi transport system energized by a H+ gradient in Leishmania amazonensis. Pi uptake and transcription of LamPho84 gene are differentially regulated during parasite life cycle. Our data suggest that Pi acquisition could be a pivotal task for the success of the parasite throughout its life cycle. Copyright © 2019 ...
Wu, Wenjie LoVerde, Philip T
Published in
Molecular and biochemical parasitology
Nuclear receptors (NRs) belong to a large protein superfamily which includes intracellular receptors for secreted hydrophobic signal molecules, such as steroid hormones and thyroid hormones. They regulate development and reproduction in metazoans by binding to the promoter region of their target gene to activate or repress mRNA synthesis. Isolation...
Elzoheiry, Manal Da'dara, Akram A Nation, Catherine S El-Beshbishi, Samar N Skelly, Patrick J
Published in
Molecular and biochemical parasitology
Schistosoma mansoni is a long-lived intravascular trematode parasite that can infect humans causing the chronic debilitating disease, schistosomiasis. We hypothesize that the action of host-interactive proteins found at the schistosome surface allows the worms to maintain a safe, anti-thrombotic and anti-inflammatory environment around them in the ...
Harris, Michael T. Jeffers, Victoria Martynowicz, Jennifer True, Jason D. Mosley, Amber L. Sullivan, William J. Jr.
Published in
Molecular and biochemical parasitology
Bianchi, Claretta Kostygov, Alexei Yu Kraeva, Natalya Záhonová, Kristína Horáková, Eva Sobotka, Roman Lukeš, Julius Yurchenko, Vyacheslav
Published in
Molecular and biochemical parasitology
Here we report that trypanosomatid flagellates of the genus Blastocrithidia possess catalase. This enzyme is not phylogenetically related to the previously characterized catalases in other monoxenous trypanosomatids, suggesting that their genes have been acquired independently. Surprisingly, Blastocrithidia catalase is less enzymatically active, co...
Kilili, Geoffrey Kimiti Shakya, Bikash Dolan, Patrick T Wang, Ling Husby, Monica L Stahelin, Robert V Nakayasu, Ernesto S LaCount, Douglas J
Published in
Molecular and biochemical parasitology
The MESA erythrocyte cytoskeleton binding (MEC) motif is a 13-amino acid sequence found in 14 exported Plasmodium falciparum proteins. First identified in the P. falciparum Mature-parasite-infected Erythrocyte Surface Antigen (MESA), the MEC motif is sufficient to target proteins to the infected red blood cell cytoskeleton. To identify host cell ta...
Loymunkong, Chaleampol Sittikul, Pichamon Songtawee, Napat Wongpanya, Ratree Boonyalai, Nonlawat
Published in
Molecular and biochemical parasitology
To survive within a red blood cell (RBC), malaria parasites establish striking modifications to the permeability, rigidity and cytoadherence properties of the host cell. This is mediated by the export of hundreds of proteins from the parasite into the erythrocyte. Plasmodium falciparum plasmepsin V (PfPMV), is an ER resident aspartic protease that ...
