Kondou, Ryota Akiyama, Yasuto Iizuka, Akira Miyata, Haruo Maeda, Chie Kanematsu, Akari Watanabe, Kyoko Ashizawa, Tadashi Nagashima, Takeshi Urakami, Kenichi
...
Published in
Molecular and Clinical Oncology
Project High-tech Omics-based Patient Evaluation (HOPE), which used whole-exome sequencing and gene expression profiling, was launched in 2014. A total of ~2,000 patients were enrolled until March 2016, and the survival time was observed up to July 2019. In our previous study, a tumor microenvironment immune type classification based on the express...
Baio, Raffaele Spiezia, Nicola Marani, Carla Schettini, Manlio
Published in
Molecular and Clinical Oncology
Invasive urothelial carcinoma has a propensity for disparate differentiation and presentation of morphological variants. Sarcomatoid carcinoma (SaC) of the bladder is an extremely uncommon and aggressive variant of bladder cancer. An accurate diagnosis for this variant is necessary, but at times difficult. Immunohistochemistry can increase the diag...
D'Agay, Melchior De Giraud Galland, Loïck Tharin, Zoe Truntzer, Caroline Ghiringhelli, Francois
Published in
Molecular and Clinical Oncology
Metastatic colorectal cancer (mCRC) is a heterogenous disease and its prognosis depends on clinical features, such as tumor sidedness, and whether it is metachronous or synchronous. However, little is known about the overall genomic characterization of mCRC in these clinical subtypes. This single-center observational study included 77 patients with...
Çoban, Ganime Yildiz, Pelin Doğan, Bayram Şahin, Nurhan Gücin, Zühal
Published in
Molecular and Clinical Oncology
Immunohistochemical and molecular studies to differentiate eosinophilic kidney tumors are gradually increasing. The present study investigated the role of transient receptor potential cation channel subfamily M member 4 (TRPM4), a non-selective cation channel associated with migration, proliferation and invasion in cancer cells, in this differentia...
Kobayashi, Kunihiko Kaira, Kyoichi Iemura, Hidetoshi Shinomiya, Shun Hashimoto, Kosuke Miura, Yu Shiono, Ayako Nishihara, Fuyumi Kagamu, Hiroshi
Published in
Molecular and Clinical Oncology
The present study selected two patients with lung cancer and epidermal growth factor receptor ( EGFR ) mutations who were treated with a programmed cell death protein 1 (PD-1) antibody and an immunomodulatory arabinomannan extracted from Mycobacterium tuberculosis . In the first case, a 67-year-old female was diagnosed with lung adenocarcinoma with...
Xu, Shenghan Zhang, Wenjun Che, Bangwei Zhang, Jinjuan He, Jun Liu, Dongdong Chen, Pan Mu, Yi Chen, Kehang Tang, Kaifa
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Published in
Molecular and Clinical Oncology
Adrenal neuroblastoma (NB) is very rare in adults. According to the literature, 90% of the patients aged
Abbas, Mahmoud Pätzel, Melanie Thurn, Angelika Brinkmann, Olaf Anselm Bettendorf, Olaf
Published in
Molecular and Clinical Oncology
Autosomal dominant polycystic kidney disease (ADPKD) is one of the best-known genetic diseases. Almost half of the patients with ADPKD will develop end-stage renal disease, and the majority of patients are treated with renal transplantation. The current study presents a case that developed papillary renal cell carcinoma (PRCC) in the native right k...
Huszno, Joanna Pigłowski, Wojciech Mazur, Magdalena Pamuła-Piłat, Jolanta Zajkowicz, Artur Kierzkowska, Anna Fiszer Wojciechowska, Małgorzata Oczko
Published in
Molecular and Clinical Oncology
The influence of BRCA1/2 variants of uncertain significance (VUSs) on the cancer risk and their association with the response to treatment is uncertain. The aim of the present study was to evaluate the role of BRCA VUS in patients with breast cancer. A total of two cases of breast cancer patients with the BRCA VUS were described. The complete codin...
De Carvalho, Ricardo Vianna Santos, Cíntia Silva Dos Santos Sant'Anna, Louisy Sanches Lima, Fernanda Ferreira Júnior, Raphael Hirata Grabois, Marília Fournaciari Mattos-Guaraldi, Ana Luíza
Published in
Molecular and Clinical Oncology
Non-diphtheria Corynebacterium species have been increasingly recognized as multidrug resistant pathogens that also infect immunocompromised patients. Automated and semi-automated phenotypic tests have been used by clinical laboratories for detection of these gram-positive rods. The present case report describes the rare pediatric case of L. aquati...
Husseini, Ziad El Haibe, Yolla Bouferraa, Youssef Kreidieh, Malek Darazi, Monita Al Mukherji, Deborah Temraz, Sally Charafeddine, Maya Shamseddine, Ali
Published in
Molecular and Clinical Oncology
The current standard of care for locally advanced rectal cancer (LARC) includes preoperative chemoradiation, followed by total mesorectal excision and adjuvant chemotherapy. This multimodality treatment improves local control but is associated with low compliance rates without clear beneficial effects on overall survival (OS) and distant metastasis...
