Asrani, Purva Hassan, Md. Imtaiyaz
Published in
Molecular and Cellular Biochemistry
The recent exposure of novel coronavirus strain, severe acute respiratory syndrome (SARS-CoV-2) has spread to different countries at an alarming rate. Faster transmission rate and genetic modifications have provoked scientists to search for an immediate solution. With an increasing death rate, it becomes important to throw some light on the life cy...
Kumar, Pravindra Sah, Ashok Kumar Tripathi, Greesham Kashyap, Anjali Tripathi, Avantika Rao, Rashmi Mishra, Prabhu C. Mallick, Koustav Husain, Amjad Kashyap, Manoj Kumar
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Published in
Molecular and Cellular Biochemistry
Since the first case reports in Wuhan, China, the SARS-CoV-2 has caused a pandemic and took lives of > 8,35,000 people globally. This single-stranded RNA virus uses Angiotensin-converting enzyme 2 (ACE2) as a receptor for entry into the host cell. Overexpression of ACE2 is mainly observed in hypertensive, diabetic and heart patients that make them ...
Wang, Wenlong Zhu, Yitang Yin, Linlin Deng, Yaoyao Chu, Guoxian Liu, Supin
Published in
Molecular and Cellular Biochemistry
Hospital-acquired pneumonia (HAP) is one of the common infections in hospitalized patients. Early and prompt diagnosis of HAP is important because it aids in the appropriate selection of antibiotics and decreases the mortality and morbidity of patients. The investigation on serum procalcitonin (PCT) levels in pediatric patients is limited. Herein w...
Yadav, Pavan Kumar Gupta, Shishir Kumar Kumar, Saroj Ghosh, Mayukh Yadav, Brijesh Singh Kumar, Dinesh Kumar, Ajay Saini, Mohini Kataria, Meena
Published in
Molecular and Cellular Biochemistry
Matrix Metalloproteinases (MMPs)-induced altered proteolysis of extracellular matrix proteins and basement membrane holds the key for tumor progression and metastasis. Matrix metalloproteinases-7 (Matrilysin), the smallest member of the MMP family also performs quite alike; thus serves as a potential candidate for anti-tumor immunotherapy. Converse...
Zhang, Keji Gao, Yuan Deng, Yuxiao Zhou, Xiao Zhu, Changqing He, Zhengyu Lv, Dan
Published in
Molecular and Cellular Biochemistry
Mesenchymal stem cells (MSCs) can alleviate acute respiratory distress syndrome (ARDS), but the mechanisms involved are unclear, especially about their specific effects on cellular mitochondrial respiratory function. Thirty mice were allocated into the Control, LPS, and LPS + Bone marrow mesenchymal stem cell (BMSC) group ( n = 10/group). Mouse alv...
Zielińska-Przyjemska, Małgorzata Kaczmarek, Mariusz Krajka-Kuźniak, Violetta Wierzchowski, Marcin Baer-Dubowska, Wanda
Published in
Molecular and Cellular Biochemistry
The present study aimed to evaluate the cytotoxicity and its mechanism of five synthetic methoxy stilbenes, namely 3,4,4ʹ-trimethoxy, 3,4,2ʹ-trimethoxy, 3,4,2ʹ,4ʹ-tetramethoxy, 3,4,2ʹ,6ʹ-tetramethoxy, and 3,4,2ʹ,4ʹ,6ʹ-pentamethoxy-trans-stilbenes (MS), in comparison with resveratrol (RSV). Human promyelocytic (HL-60) and monocytic leukemia (THP-1) ...
Wei, Wen-Ying Zhao, Qing Zhang, Wen-Zhong Wang, Mao-Jing Li, Yan Wang, Shi-Zhong Zhang, Ning
Published in
Molecular and cellular biochemistry
Secreted frizzled-related protein 2 (sFRP2) has been reported to be involved in cardiovascular diseases. However, its role in cardiac hypertrophy induced by pressure overload is still elusive. We aimed to examine the role of sFRP2 in the development of cardiac hypertrophy in vivo and in vitro. Following cardiac hypertrophy stimulated by aortic band...
Messmann, Rebecca Dietl, Alexander Wagner, Stefan Domenig, Oliver Jungbauer, Carsten Luchner, Andreas Maier, Lars S. Schopka, Simon Hirt, Stephan Schmid, Christof
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Published in
Molecular and Cellular Biochemistry
Heart transplantation is often an unrealizable therapeutic option for end-stage heart failure, which is why mechanical left ventricular assist devices (LVADs) become an increasingly important therapeutic alternative. Currently, there is a lack of information about molecular mechanisms which are influenced by LVADs, particularly regarding the pathop...
Shoieb, Sherif M. El-Kadi, Ayman O. S.
Published in
Molecular and Cellular Biochemistry
Several reports demonstrated the direct contribution of cytochrome P450 1B1 (CYP1B1) enzyme and its associated cardiotoxic mid-chain, hydroxyeicosatetraenoic acid (HETEs) metabolites in the development of cardiac hypertrophy. Resveratrol is commercially available polyphenol that exerts beneficial effects in wide array of cardiovascular diseases inc...
Wu, Yaqian Cao, Yanan Liu, Haijing Yao, Mengfei Ma, Ningning Zhang, Bo
Published in
Molecular and Cellular Biochemistry
Hypoxia-inducible factors (HIFs) are key mediators expressed under hypoxic condition and involved in many kinds of disease such as cancer and abnormal angiogenesis. Thus, development of their inhibitor has been extensively explored. Here, we describe a finding that Remodelin, a specific inhibitor of NAT10, could also inhibit the expression of HIFs....
