LukS-PV Inhibits Hepatocellular Carcinoma Progression by Downregulating HDAC2 Expression
...Published in Molecular Therapy Oncolytics
Decreasing the Susceptibility of Malignant Cells to Infection Does Not Impact the Overall Efficacy of Myxoma Virus-Based...
Published in Molecular Therapy Oncolytics
Our work highlights that tumors do not have to be highly susceptible to direct viral infection to be treatable by oncolytic therapy. Instead, even minimal viral replication within the tumor can be sufficient to effectively delay tumor growth by activating endogenous immune surveillance.
Expression of Oncolytic Adenovirus-Encoded RNAi Molecules Is Most Effective in a pri-miRNA Precursor Format
Published in Molecular Therapy Oncolytics
van Beusechem and colleagues present a method to construct oncolytic adenoviruses expressing gene-silencing molecules in cancer cells. They show that molecules expressed in pri-miRNA format are most effective. This knowledge is useful to construct next-generation oncolytic adenoviruses silencing selected target genes to achieve effective oncolytic ...
Improving the Efficacy of EGFR Inhibitors by Topical Treatment of Cutaneous Squamous Cell Carcinoma with miR-634 Ointmen...
Published in Molecular Therapy Oncolytics
In this study, Inoue et al. demonstrate that topical treatment with miR-634 ointment improves the efficacy of EGFR tyrosine kinase inhibitor (TKI) for cutaneous squamous cell carcinoma (cSCC) by triggering severe energetic stress via concurrent targeting of multiple cytoprotective processes, including autophagy, antioxidative scavenger, anti-apopto...
lncRNA DUXAP8 Facilitates Multiple Malignant Phenotypes and Resistance to PARP Inhibitor in HCC via Upregulating FOXM1
Published in Molecular Therapy Oncolytics
This study provides substantial evidence that targeting DUXAP8 or upregulating miR-485-5p may suppress HCC progression and enhances sensitivity to PARPi. Considering the extended regulatory networks known to involve DUXAP8, miR-485-5p, or FOXM1 in cancer development, it is important to assess the importance of this axis in other types of cancer.
Mesenchymal Stem Cell-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6...
...Published in Molecular Therapy Oncolytics
This study uncovered a novel mechanism by which chemotherapy modulates MSC activity to induce resistance through exosome secretion, which advances the understanding of cancer therapy resistance and should be of substantial interest to the cancer research community.
Oncolytic Rhabdovirus Vaccine Boosts Chimeric Anti-DEC205 Priming for Effective Cancer Immunotherapy
...Published in Molecular Therapy Oncolytics
Replication-deficient Ad5 vectors are used for gene therapy and vaccination. Tzelepis and colleagues show that seropositivity to Ad5, highly prevalent in the human population, abrogates an Ad5 vaccination response. Alternatively, they show the efficacy of αDEC205 antibody-antigen fusion in the context of an oncolytic rhabdovirus cancer vaccine targ...
Retargeted and Multi-cytokine-Armed Herpes Virus Is a Potent Cancer Endovaccine for Local and Systemic Anti-tumor Treatm...
...Published in Molecular Therapy Oncolytics
Fully virulent tumor retargeted HSV oncolytic viruses (THVs) are novel immunotherapeutic agents with increased specificity, safety, and potency. De Lucia et al. propose the use of a hHER2 THV expressing IL-12 and GM-CSF as a strategy to potentiate anti-tumor efficacy in combination with anti-PD1, opening future perspectives for local and systemic t...
Regulation of Glycolysis by Non-coding RNAs in Cancer: Switching on the Warburg Effect
Published in Molecular Therapy Oncolytics
Many ncRNAs have been implicated in the switch to glycolysis, thus increasing the overall aggressiveness of the tumor. Not only could further investigation into the mechanisms and functions of ncRNAs allow the discovery of additional prognostic biomarkers, but it could also be beneficial for the development of novel therapeutic approaches.
Methylation of the Promoter Region of the Tight Junction Protein-1 by DNMT1 Induces EMT-like Features in Multiple Myelom...
...Published in Molecular Therapy Oncolytics
We demonstrate that DNA methyltransferases contribute to the downregulation of TJP1 by DNMT1, thus subsequently promoting the development of EMT-mediated MM progression and the BM microenvironment, leading to MM metastasis. We believe that TJP1 expression and methyltransferase inhibitors would facilitate therapies combined with bortezomib in clinic...
