Mechanisms for substance use disorders in COVID-19
Published in Molecular Psychiatry
Prevalence of posttraumatic stress disorder after infectious disease pandemics in the twenty-first century, including CO...
...Published in Molecular Psychiatry
Pandemics have become more frequent and more complex during the twenty-first century. Posttraumatic stress disorder (PTSD) following pandemics is a significant public health concern. We sought to provide a reliable estimate of the worldwide prevalence of PTSD after large-scale pandemics as well as associated risk factors, by a systematic review and...
The influence of X chromosome variants on trait neuroticism.
...Published in Molecular psychiatry
Autosomal variants have successfully been associated with trait neuroticism in genome-wide analysis of adequately powered samples. But such studies have so far excluded the X chromosome from analysis. Here, we report genetic association analyses of X chromosome and XY pseudoautosomal single nucleotide polymorphisms (SNPs) and trait neuroticism usin...
WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling.
Published in Molecular psychiatry
Adult hippocampal neurogenesis, a process considered important for hippocampal function, is regulated at multiple molecular levels. Mutations in the gene encoding the WD40 repeat-containing protein WDR81 are associated with neurological disorders, including cerebellar ataxia, mental retardation, quadrupedal locomotion syndrome (CAMRQ2), and microce...
Complement pathway changes at age 12 are associated with psychotic experiences at age 18 in a longitudinal population-ba...
...Published in Molecular psychiatry
The complement cascade is a major component of the immune defence against infection, and there is increasing evidence for a role of dysregulated complement in major psychiatric disorders. We undertook a directed proteomic analysis of the complement signalling pathway (n = 29 proteins) using data-independent acquisition. Participants were recruited ...
Transvascular delivery of α-synuclein preformed fibrils, using the RVG9R delivery system, generates α-synuclein patholog...
...Published in Molecular Psychiatry
Systemic α-synuclein injection triggers selective neuronal pathology as seen in patients with Parkinson's disease.
...Published in Molecular psychiatry
Parkinson's disease (PD) is an α-synucleinopathy characterized by the progressive loss of specific neuronal populations. Here, we develop a novel approach to transvascularly deliver proteins of complex quaternary structures, including α-synuclein preformed fibrils (pff). We show that a single systemic administration of α-synuclein pff triggers path...
Decoding the temporal nature of brain GR activity in the NFκB signal transition leading to depressive-like behavior
...Published in Molecular Psychiatry
The fine-tuning of neuroinflammation is crucial for brain homeostasis as well as its immune response. The transcription factor, nuclear factor-κ-B (NFκB) is a key inflammatory player that is antagonized via anti-inflammatory actions exerted by the glucocorticoid receptor (GR). However, technical limitations have restricted our understanding of how ...
The impact of quarantine on mental health status among general population in China during the COVID-19 pandemic
...Published in Molecular Psychiatry
Quarantine and isolation measures urgently adopted to control the COVID-19 pandemic might potentially have negative psychological and social effects. We conducted this cross-sectional, nationwide study to ascertain the psychological effect of quarantine and identify factors associated with mental health outcomes among population quarantined to furt...
Irradiation-induced changes in neural progenitor cells are reversed by lithium: Immature newborn dentate granule neurons...
...Published in Molecular Psychiatry
