Published in Molecular Metabolism
Background The abundance of energy metabolites is intimately interconnected with the activity of chromatin-modifying enzymes in order to guarantee the finely tuned modulation of gene expression in response to cellular energetic status. Metabolism-induced epigenetic gene regulation is a key molecular axis for the maintenance of cellular homeostasis,...
Published in Molecular Metabolism
• Hunger increases incentive motivation in lean but not obese humans. • Impaired peripheral insulin sensitivity reduces the motivational effect of hunger. • GLP-1 modulates incentive motivation independently of incentive type (food and non-food reward). • GLP-1 analogue application normalises the motivational effect of hunger depending on insulin s...
Published in Molecular Metabolism
• β1 and β3 integrins interact with insulin signaling to regulate white adipocyte insulin sensitivity and systemic metabolism. • Impaired integrin activity results in lipodystrophy in the absence of hepatosteatosis. • β1 integrin activity regulates energy expenditure and vascular permeability in brown adipose tissue.
Published in Molecular metabolism
Childhood obesity is a strong risk factor for adult obesity, type 2 diabetes, and cardiovascular disease. The mechanisms that link early adiposity with late-onset chronic diseases are poorly characterised. We developed a mouse model of early adiposity through litter size reduction. Mice reared in small litters (SLs) developed obesity, insulin resis...
Published in Molecular Metabolism
• Removal of sensory spinal neurons expressing CGRPα mitigates diet-induced obesity. • CGRPα afferents antagonize adaptive thermogenesis in brown adipose tissue. • Loss of CGRPα afferents leads to enhanced cold perception and vasoconstriction. • Specific adipose denervation of CGRPα afferents does not modulate energy metabolism.
Published in Molecular Metabolism
Published in Molecular Metabolism
• Nox4 and hydrogen peroxide (H2O2) activate genes involved in skeletal muscle metabolism after acute exercise. • Global deletion of Nox4 attenuates muscle glucose and fatty acid oxidation post-acute exercise. • Endothelial-specific deletion of Nox4 blunts acute adaptation to exercise in muscle suggesting inter-tissue cross-talk. • Nox4 is required...
Published in Molecular metabolism
More than 300 genetic variants have been robustly associated with measures of human adiposity. Highly penetrant mutations causing human obesity do so largely by disrupting satiety pathways in the brain and increasing food intake. Most of the common obesity-predisposing variants are in, or near, genes expressed highly in the brain, but little is kno...
Published in Molecular metabolism
The dorsal vagal complex (DVC) senses insulin and controls glucose homeostasis, feeding behaviour and body weight. Three-days of high-fat diet (HFD) in rats are sufficient to induce insulin resistance in the DVC and impair its ability to regulate feeding behaviour. HFD-feeding is associated with increased dynamin-related protein 1 (Drp1)-dependent ...
Published in Molecular Metabolism
