Serrano-Maciá, Marina Simón, Jorge González-Rellan, Maria J. Azkargorta, Mikel Goikoetxea-Usandizaga, Naroa Lopitz-Otsoa, Fernando De Urturi, Diego Saenz Rodríguez-Agudo, Rubén Lachiondo-Ortega, Sofia Mercado-Gomez, Maria
...
Published in
Molecular Metabolism
• Hepatic neddylation is induced in clinical and pre-clinical NAFLD. • Neddylation inhibition reduces hepatic steatosis in pre-clinical models of NAFLD. • Neddylation inhibition boosts fatty acid oxidation through a DEPTOR/mTOR axis. • Neddylation inhibition reduces hepatic inflammation and lipid peroxidation in NAFLD. • Serum NEDD8 levels correlat...
Eshwaran, Rachana Kolibabka, Matthias Poschet, Gernot Jainta, Gregor Zhao, Di Teuma, Loic Murillo, Katharina Hammes, Hans-Peter Schmidt, Martina Wieland, Thomas
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Published in
Molecular Metabolism
• The hexosamine biosynthesis pathway (HBP) is activated in diabetic retinopathy (DR), which manifests as vascular and neuronal damage in the retina. • Glucosamine, metabolized in the HBP, is a widely used oral supplement for osteoarthritis treatment. • Glucosamine supplementation improved neuronal function in retinas of mice with experimental DR, ...
Stoffel, Wilhelm Binczek, Erika Schmidt-Soltau, Inga Brodesser, Susanne Wegner, Ina
Published in
Molecular Metabolism
• ω3-and ω6-PUFA synthesis deficiency in the auxotrophic fads2−/− mouse. • Perturbs liver membrane lipidomes and lipid metabolism • Remodels the lipid droplet- and serum lipoprotein-systems • Prevents PUFA-derived peroxidation products, protein modification, and inflammation • Protects from high fat/high cholesterol (“Western diet”) that promotes a...
Serrano, Joan Seflova, Jaroslava Park, Jihye Pribadi, Marsha Sanematsu, Keisuke Shigemura, Noriatsu Serna, Vanida Yi, Fanchao Mari, Andrea Procko, Erik
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Published in
Molecular Metabolism
• Sweet taste receptors (STR) have functional roles beyond taste perception. • The TAS1R2 gene of STR is highly polymorphic, suggesting nutrient-dependent adaptive roles. • The Ile191Val variant of TAS1R2 gene causes a partial STR loss-of-function. • Val carriers have reduced glucose excursions mirroring TAS1R2-KO mice.
D'Onofrio, Nunzia Sardu, Celestino Trotta, Maria Consiglia Scisciola, Lucia Turriziani, Fabrizio Ferraraccio, Franca Panarese, Iacopo Petrella, Lella Fanelli, Mara Modugno, Piero
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Published in
Molecular Metabolism
• The identification of novel molecular targets of atherosclerosis progression is of utmost importance in diabetic patients. • The occurrence of SGLT2 receptors on the endothelial cells of atherosclerotic plaques may be an attractive therapeutic option for atherosclerosis in patients with diabetes. • SGLT2/SIRT6 represents an attractive option, giv...
Škop, Vojtěch Xiao, Cuiying Liu, Naili Gavrilova, Oksana Reitman, Marc L.
Published in
Molecular Metabolism
• Changing housing density changes thermal physiology and metabolic rate. • Singly housed mice are more affected by fasting and by cold temperatures. • Single housing is more sensitive than group housing for detecting thermal phenotypes. • Certain principles of thermal physiology are masked by group housing. • Male and female mice respond different...
Halbgebauer, D. Roos, J. Funcke, J.B. Neubauer, H. Hamilton, B.S. Simon, E. Amri, E.Z. Debatin, K.M. Wabitsch, M. Fischer-Posovszky, P.
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Published in
Molecular Metabolism
• Inhibition of LTBP2 and LTBP3 reduces secretion of TGFβ2. • Both knockout of LTBP2/3 or TGFβ2 inhibit UCP1 expression and mitochondrial respiration in human adipocytes. • Expression of TGFβ2 correlates with UCP1 expression in human adipose tissue. • Treatment with TGFβ2 rescues inhibition of UCP1 by LTBP knockout during adipogenesis.
Lin, Yijun Chen, Lingling You, Xue Li, Zixuan Li, Chenchen Chen, Yan
Published in
Molecular Metabolism
Background The cycle of feeding and fasting is fundamental to life and closely coordinated with changes of metabolic programs. During extended starvation, ketogenesis coupled with fatty acid oxidation in the liver supplies ketone bodies to extrahepatic tissues as the major form of fuel. In this study, we demonstrated that PAQR9, a member of the pro...
Casteels, Tamara Zhang, Yufeng Frogne, Thomas Sturtzel, Caterina Lardeau, Charles-Hugues Sen, Ilke Liu, Xiaocheng Hong, Shangyu Pauler, Florian M. Penz, Thomas
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Published in
Molecular Metabolism
• Pharmacological FoxO1 inhibition can model many aspects of beta cell dedifferentiation in vitro , including loss of beta cell identity and gain of progenitor and alpha cell markers. • Through a high content screen with this cellular dedifferentiation model, we identified the FDA-approved small molecule, loperamide, to counter FoxO inhibitor-media...
Oteng, Antwi-Boasiako Higuchi, Sei Banks, Alexander S. Haeusler, Rebecca A.
Published in
Molecular Metabolism
• Presence of MCA does not necessarily protect against diet-induced obesity. • Cyp2c deficiency promotes resistance to diet-induced obesity in males. • Cyp2c-knockout mice have decreased the ratio of 12α-OH/non-12α-OH BAs that promotes decreased intestinal lipid absorption. • Cyp2c-knockout mice have improved glucose homeostasis. • Cyp2c-deficiency...
