Barilla, Serena Liang, Ning Mileti, Enrichetta Ballaire, Raphaëlle Lhomme, Marie Ponnaiah, Maharajah Lemoine, Sophie Soprani, Antoine Gautier, Jean-Francois Amri, Ez-Zoubir
...
Published in
Molecular metabolism
Adipogenesis is critical for adipose tissue remodeling during the development of obesity. While the role of transcription factors in the orchestration of adipogenic pathways is already established, the involvement of coregulators that transduce regulatory signals into epigenome alterations and transcriptional responses remains poorly understood. Th...
Masson, Stewart W.C. Sorrenson, Brie Shepherd, Peter R. Merry, Troy L.
Published in
Molecular Metabolism
• Deletion of β-catenin from the muscles of adult mice attenuates skeletal muscle glucose uptake. • Insulin stimulates phosphorylation of β-cateninS552 by a mechanism involving Akt, and this is required for insulin's effects on both GLUT4 trafficking and actin remodelling. • Insulin promotes β-catenin/M-cadherin binding, to support cortical actin r...
Roh, Hyun Cheol Kumari, Manju Taleb, Solaema Tenen, Danielle Jacobs, Christopher Lyubetskaya, Anna Tsai, Linus T.-Y. Rosen, Evan D.
Published in
Molecular Metabolism
• Adipocytes after HFD intake exhibit defects in cellular identity maintenance. • Adipocytes develop actin filament networks in obesity. • Altered PPAR γ activity mediates defective adipocyte identity phenotypes. • TGFβ-SMAD pathways promote HFD-induced aberrant phenotype of adipocytes.
Fazeli, Pouneh K. Zhang, Yang O'Keefe, John Pesaresi, Tristan Lun, Mingyue Lawney, Brian Steinhauser, Matthew L.
Published in
Molecular Metabolism
• Prolonged fasting drives an inflammatory transcriptome in human subcutaneous fat. • Fasting induction of a macrophage signature includes the transcription factor SPIC. • SPIC expression in macrophages recapitulates aspects of the fasting transcriptome. • Prolonged fasting drives circulating markers of systemic inflammation. • Fasting drives lysos...
Azar, Shahar Udi, Shiran Drori, Adi Hadar, Rivka Nemirovski, Alina Vemuri, Kiran V. Miller, Maya Sherill-Rofe, Dana Arad, Yhara Gur-Wahnon, Devorah
...
Published in
Molecular Metabolism
• PPARα is the top-ranked NAFLD-related gene that is coevolved with the CB1R. • Hepatic PPARα and SIRT1 expression and activity are regulated by the CB1R. • Reversal of hepatic steatosis by peripheral CB1R blockade requires intact SIRT1 and PPARα signaling. • Hepatic PPARα and SIRT1 are direct targets of miR-22, whose expression is regulated via CB...
Dusabimana, Theodomir Kim, So Ra Park, Eun Jung Je, Jihyun Jeong, Kyuho Yun, Seung Pil Kim, Hye Jung Kim, Hwajin Park, Sang Won
Published in
Molecular Metabolism
• P2Y2R deficiency in mice with diabetic nephropathy: • Ameliorates plasma and urinary markers of kidney injury. • Attenuates glomerular sclerosis and podocyte loss. • Attenuates tubular cell apoptosis and interstitial fibrosis. • Improves autophagic response by increasing autophagy flux and its regulatory proteins. • Modulates AKT-mediated FOXO3a ...
Yuan, Feixiang Yin, Hanrui Deng, Yalan Jiao, Fuxin Jiang, Haizhou Niu, Yuguo Chen, Shanghai Ying, Hao Zhai, Qiwei Chen, Yan
...
Published in
Molecular Metabolism
• POMC neuronal Smad7 increased in high-fat diet-fed and middle-aged mice. • Overexpression of Smad7 in POMC neurons disrupts glucose metabolism. • Smad7 deletion in POMC neurons prevents diet- or age-induced glucose disorders. • Smad7 regulates glucose metabolism by PP1c-mediated hypothalamic insulin resistance.
Mittenbühler, Melanie J. Saedler, Katarzyna Nolte, Hendrik Kern, Lara Zhou, Jun Qian, Shu-Bing Meder, Lydia Ullrich, Roland T. Brüning, Jens C. Wunderlich, F. Thomas
...
Published in
Molecular Metabolism
• Hepatic FTO is dispensable for whole body metabolism. • FTO is dynamically regulated upon acute liver damage and controls proliferation. • Hepatic FTO function protects against the development of hepatocellular carcinoma (HCC). • Cul4a is a downstream target of FTO, and Cul4a knockdown reduces damage-induced proliferation in FTOL−KO livers.
Saget, Sarah Cong, Rong Decourtye, Lyvianne Endale, Marie-Laure Martinerie, Laetitia Girardet, Clémence Perret, Claire Clemessy, Maud Leneuve, Patricia Dinard, Laetitia
...
Published in
Molecular Metabolism
• Male mice are highly sensitive to changes in nutrition during the perinatal period. • Post-natal nutrition modulates metabolic diseases induced by IUGR in male mice. • Metabolic programming by perinatal nutrition involves epigenetic mechanisms. • Pre-symptomatic IUGR mice present molecular alterations of the insulin pathway. • Plasma miRNA19a-3p ...
Rehal, Sonia Kataru, Raghu P. Hespe, Geoffrey E. Baik, Jung Eun Park, Hyeung Ju Ly, Catherine Shin, JinYeon Mehrara, Babak J.
Published in
Molecular Metabolism
• Increased iNOS+ cells around mesenteric lymphatics of high fat diet-induced obese mice. • iNOS knockout mice are protected from obesity-induced lymphatic dysfunction. • Lymphatic endothelial cells are highly sensitive to nitrosative stress. • Nitrosative stress causes lymphatic gene regulation. • Lymphatic injury alone enhances iNOS+ cells and ca...
