Lin, Wei Li, Xing-fu Ren, Dong-cheng Song, Meng Duan, Li Liu, Jin-zhu Zhan, Zi-rui
Published in
Molecular Medicine
Background Osteoporosis is a common phenomenon in HIV patients on tenofovir treatment, but its underlying mechanisms remain to be explored. Methods Quantitative real-time PCR was performed to analyze the expression of miR-302, miR-101, miR-145 and osteoclast-specific genes in the serum of HIV patients treated with tenofovir and ZOL. ELISA was used ...
Tang, Da Fu, Guang Li, Wenbo Sun, Ping Loughran, Patricia A. Deng, Meihong Scott, Melanie J. Billiar, Timothy R.
Published in
Molecular Medicine
Background Hepatic ischemia/reperfusion (I/R) injury can be a major complication following liver surgery contributing to post-operative liver dysfunction. Maresin 1 (MaR1), a pro-resolving lipid mediator, has been shown to suppress I/R injury. However, the mechanisms that account for the protective effects of MaR1 in I/R injury remain unknown. Meth...
Ntetsika, Theodora Papathoma, Paraskevi-Evita Markaki, Ioanna
Published in
Molecular Medicine
Parkinson’s disease (PD) is the second more common neurodegenerative disease with increasing incidence worldwide associated to the population ageing. Despite increasing awareness and significant research advancements, treatment options comprise dopamine repleting, symptomatic therapies that have significantly increased quality of life and life expe...
Menz, Anne Weitbrecht, Timo Gorbokon, Natalia Büscheck, Franziska Luebke, Andreas M. Kluth, Martina Hube-Magg, Claudia Hinsch, Andrea Höflmayer, Doris Weidemann, Sören
...
Published in
Molecular Medicine
Background Cytokeratin 18 (CK18) is an intermediate filament protein of the cytokeratin acidic type I group and is primarily expressed in single-layered or “simple” epithelial tissues and carcinomas of different origin. Methods To systematically determine CK18 expression in normal and cancerous tissues, 11,952 tumor samples from 115 different tumor...
Zhu, Ying Ke, Kun-Bin Xia, Zhong-Kun Li, Hong-Jian Su, Rong Dong, Chao Zhou, Feng-Mei Wang, Lin Chen, Rong Wu, Shi-Guo
...
Published in
Molecular Medicine
Background Cyclin-dependent kinases 2/4/6 (CDK2/4/6) play critical roles in cell cycle progression, and their deregulations are hallmarks of hepatocellular carcinoma (HCC). Methods We used the combination of computational and experimental approaches to discover a CDK2/4/6 triple-inhibitor from FDA approved small-molecule drugs for the treatment of ...
Su, Dongmei Li, Yanhua Guan, Lina Li, Qian Shi, Cuige Ma, Xu Song, Yonghui
Published in
Molecular Medicine
BackgroundGestational diabetes mellitus is a risk factor for congenital heart defects. The article aimed to investigate the expression and roles of MST1, YAP1, Last1/2 and Survivin in modulating HG-induced cardiomyocyte apoptosis and maternal diabetes-induced heart abnormality.MethodsDiabetes mellitus was induced in rats using streptozotocin. The p...
Chen, Hui-Yong Xiao, Ze-Zhou Ling, Xiao Xu, Rong-Ning Zhu, Peng Zheng, Shao-Yi
Published in
Molecular Medicine
AimsMyocardial ischemia is the most common form of cardiovascular disease and the leading cause of morbidity and mortality. Understanding the mechanisms is very crucial for the development of effective therapy. Therefore, this study aimed to investigate the functional roles and mechanisms by which ELAVL1 regulates myocardial ischemia and reperfusio...
Liu, Feng Song, De-Ye Huang, Jun Yang, Hong-Qi You, Di Ni, Jiang-Dong
Published in
Molecular Medicine
BackgroundOsteoarthritis (OA) is the most common articular disorder, leading to joint malfunction and disability. Although the incidence of OA is increasing globally, the treatment of OA is very limited. LncRNA CIR has been implicated in OA through unclear mechanisms. Here, we investigated the role of lncRNA CIR in chondrogenic differentiation.Meth...
Liu, Meixuan Lu, Jingjing Zhang, Qian Zhang, Yunxuan Guo, Zhongliang
Published in
Molecular Medicine
BackgroundHouse dust mite (HDM) inhalation can cause airway epithelial damage which is implicated in the process of airway inflammation in asthma. High mobility group box 1 (HMGB1) is critically required for cellular damage and apoptosis as an important endogenous danger signal. Recently, Clara cell 16KDa protein (CC16) has been identified to exert...
Ji, Hao Wang, Juan Lu, Binbin Li, Juan Zhou, Jing Wang, Li Xu, Shufen Peng, Peng Hu, Xuezhen Wang, Keming
...
Published in
Molecular Medicine
BackgroundLncRNA can regulate gene at various levels such as apparent genetics, alternative splicing, and regulation of mRNA degradation. However, the molecular mechanism of LncRNA in cholangiocarcinoma is still unclear. This deserves further exploration.MethodsWe investigated the expression of AGAP2-AS1 in 32 CCA tissues and two CCA cell lines. We...
