Hu, Xilin Xu, Hanlin Xue, Qianwen Wen, Ruran Jiao, Wenjie Tian, Kaihua
Published in
Molecular Medicine
Background Immune checkpoint inhibitors (ICIs) have witnessed the achievements of convincing clinical benefits that feature the significantly prolonged overall survival (OS) of patients suffering from advanced non-small cell lung cancer (NSCLC), according to reports recently. Sensitivity to immunotherapy is related to several biomarkers, such as PD...
Gao, Wei Zhang, Ying
Published in
Molecular Medicine
Background Inflammation plays an important role in the development of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). The long non-coding RNA (lncRNA) MINCR is closely related to inflammation injury. This study was performed to explore the protective effects and mechanisms of MINCR in lipopolysaccharide (LPS)-induced lung in...
Hayuningtyas, Ria Aryani Han, Myeonggil Choi, Seoyeon Kwak, Man Sup Park, In Ho Lee, Ji-Hyun Choi, Ji Eun Kim, Dae Ki Son, Myoungsun Shin, Jeon-Soo
...
Published in
Molecular Medicine
Background C1q has been reported to reveal complement-independent roles in immune and non-immune cells. C1q binds to its specific receptors to regulate distinct functions that rely on the environment and cell types. Discoidin domain receptor 2 (DDR2) is activated by collagen and functions in wound healing by controlling matrix metalloproteinase (MM...
Chen, Wujun Zhong, Yingjie Feng, Nuan Guo, Zhu Wang, Shuai Xing, Dongming
Published in
Molecular Medicine
Age-related cardiovascular disease is the leading cause of death in elderly populations. Coxibs, including celecoxib, valdecoxib, etoricoxib, parecoxib, lumiracoxib, and rofecoxib, are selective cyclooxygenase-2 (COX-2) inhibitors used to treat osteoarthritis and rheumatoid arthritis. However, many coxibs have been discontinued due to adverse cardi...
Chen, Senxiang Liu, Da Zhou, Zimo Qin, Sen
Published in
Molecular Medicine
Background Osteoporosis is a widespread and serious metabolic bone disease. At present, revealing the molecular mechanisms of osteoporosis and developing effective prevention and treatment methods are of great significance to health worldwide. LncRNA is a non-coding RNA peptide chain with more than 200 nucleotides. Researchers have identified many ...
Allavena, Paola Digifico, Elisabeth Belgiovine, Cristina
Published in
Molecular Medicine
Myeloid cells infiltrating tumors are gaining ever growing attention in the last years because their pro-tumor and immunosuppressive functions are relevant for disease progression and therapeutic responses. The functional ambiguity of tumor-associated macrophages (TAMs), mostly promoting tumor evolution, is a challenging hurdle. This is even more e...
Begemann, Martin Gross, Oliver Wincewicz, Dominik Hardeland, Rüdiger Daguano Gastaldi, Vinicius Vieta, Eduard Weissenborn, Karin Miskowiak, Kamilla W. Moerer, Onnen Ehrenreich, Hannelore
...
Published in
Molecular Medicine
Background Since fall 2019, SARS-CoV-2 spread world-wide, causing a major pandemic with estimated ~ 220 million subjects affected as of September 2021. Severe COVID-19 is associated with multiple organ failure, particularly of lung and kidney, but also grave neuropsychiatric manifestations. Overall mortality reaches > 2%. Vaccine development has th...
Miao, Xiaoyan Mao, Ren You, Yujia Zhou, Huichao Qiu, Chen Li, Xuehua Chen, Zhihui Ren, Jie Chen, Minhu Wang, Ping
...
Published in
Molecular Medicine
Background While anti-tumor necrosis factor alpha (TNF-α) therapy has been proven effective in inflammatory bowel disease (IBD), approximately 40% of patients lose the response. Transmembrane TNF-α (mTNF-α) expression in the intestinal mucosa is correlated with therapeutic efficacy, and quantification of mTNF-α expression is significant for predict...
Cui, Changmeng Wang, Changshui Jin, Feng Yang, Mengqi Kong, Lingsheng Han, Wenxiu Jiang, Pei
Published in
Molecular Medicine
Background The present study aimed to further explore the potential interaction between oxidative stress and autophagy in the progression of traumatic brain injury (TBI) and therapeutic mechanism of calcitriol, the active form of vitamin D (VitD). Methods Neuroprotective effects of calcitriol were examined following TBI. We further evaluated the im...
Liu, Binfeng Liu, Zhendong Wang, Yanbiao Lian, Xiaoyu Han, Zhibin Cheng, Xingbo Zhu, Yongjie Liu, Runze Zhao, Yaoye Gao, Yanzheng
...
Published in
Molecular Medicine
Background GINS4 , an indispensable component of the GINS complex, is vital for a variety of cancer. However, no known empirical research has focused on exploring relationships between GINS4 and glioma. Thus, this study aims to understand and explain the role of GINS4 in glioma. Method First, we used the data in the CGGA, TCGA, GEO, GEPIA, and HPA ...
