Nguyen, Ngan Xu, Simin Lam, Terence Yin Weng Liao, Wupeng Wong, W. S. Fred Ge, Ruowen
Published in
Molecular Medicine
Background Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) are clinical syndromes characterized by acute lung inflammation, pulmonary edema and hypoxemia, with up to 50% mortality rate without effective pharmacological therapy. Following the acute inflammation, repair and remodeling occurs which in some cases resulting in lung fibr...
Fang, Peng-Hsiang Lai, Ying-Ying Chen, Chih-Ling Wang, Hsin-Yu Chang, Ya-Ning Lin, Yung-Chang Yan, Yu-Ting Lai, Cheng-Hung Cheng, Bill
Published in
Molecular medicine (Cambridge, Mass.)
Complete healing of diabetic wounds continues to be a clinically unmet need. Although robust therapies such as stem cell therapy and growth factor treatment are clinically applied, these treatments are costly for most diabetic wound patients. Therefore, a cheaper alternative is needed. Cobalt protoporphyrin (CoPP) has recently been demonstrated to ...
Quintero-Villegas, Alejandro Valdés-Ferrer, Sergio Iván
Published in
Molecular Medicine
5-HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin receptors. Their role in health and disease, particularly as mediators of, and druggable targets for, neurodegenerative diseases, is incompletely understood. Unlike other serotonin receptors, for which abundant preclinical and clinical data evaluating their effe...
Lao, Mengyi Zhang, Xiaozhen Yang, Hanshen Bai, Xueli Liang, Tingbo
Published in
Molecular Medicine
Cancer is the leading cause of mortality worldwide. Regulator of calcineurin 1 (RCAN1), as a patent endogenous inhibitor of calcineurin, plays crucial roles in the pathogenesis of cancers. Except for hypopharyngeal and laryngopharynx cancer, high expression of RCAN1 inhibits tumor progression. Molecular antitumor functions of RCAN1 are largely depe...
Wang, Wenxin Geng, Jie Wu, Xiaohan Zhang, Jianguang Zheng, Chenna Rao, Huachun Li, Tianyu Diao, Yong Yang, Huiyong
Published in
Molecular Medicine
At present, the molecular mechanisms underlying inflammation remain unclear. In recent years, research on inflammation has focused on stimulating cell inflammation by using exogenous pro-inflammatory substances such as lipopolysaccharide (LPS) or inflammatory factors. To investigate the molecular mechanism of inflammation from a new perspective, we...
Ahonen, Maria A. Höring, Marcus Nguyen, Van Dien Qadri, Sami Taskinen, Juuso H. Nagaraj, Meghana Wabitsch, Martin Fischer-Posovszky, Pamela Zhou, You Liebisch, Gerhard
...
Published in
Molecular Medicine
Background Thyroid hormone responsive protein (THRSP) is a lipogenic nuclear protein that is highly expressed in murine adipose tissue, but its role in humans remains unknown. Methods We characterized the insulin regulation of THRSP in vivo in human adipose tissue biopsies and in vitro in Simpson-Golabi-Behmel syndrome (SGBS) adipocytes . To this e...
Lin, Ruo-Kai Su, Chih-Ming Lin, Shih-Yun Thi Anh Thu, Le Liew, Phui-Ly Chen, Jian-Yu Tzeng, Huey-En Liu, Yun-Ru Chang, Tzu-Hao Lee, Cheng-Yang
...
Published in
Molecular Medicine
Background Approximately 25% of patients with early-stage breast cancer experience cancer progression throughout the disease course. Alterations in TMEM240 in breast cancer were identified and investigated to monitor treatment response and disease progression. Methods Circulating methylated TMEM240 in the plasma of breast cancer patients was used t...
Ni, Jiali Zhu, Haiyan Lu, Li Zhao, Zihe Jiang, Jiaxuan You, Xiaokang Wang, Yuzhu Ma, Yuliang Yang, Zirui Hou, Yayi
...
Published in
Molecular medicine (Cambridge, Mass.)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder that results from widespread immune complex deposition and secondary tissue injury. Hydroxychloroquine (HCQ) has been used clinically to treat SLE, while its exact mechanism has still remained elusive. Some studies have shown that myeloid-derived suppressor cells (MDSCs) play a vit...
Deng, Ran Wang, Yan Bu, Yanhong Wu, Hong
Published in
Molecular Medicine
Background Hypoxia is one of the important characteristics of synovial microenvironment in rheumatoid arthritis (RA), and plays an important role in synovial hyperplasia. In terms of cell survival, fibroblast-like synovial cells (FLSs) are relatively affected by hypoxia. In contrast, fibroblast-like synovial cells from patients with RA (RA-FLSs) ar...
Zhang, Yu Gu, Xinliang Qin, Xinyue Huang, Yuejiao Ju, Shaoqing
Published in
Molecular Medicine
Background Gastric cancer (GC) is one of the diseases that endanger human health with high morbidity and mortality. The positive rates of traditional biomarkers in the diagnosis of GC are low, so it is necessary to find biomarkers with high sensitivity to increase the detection rate. tRNA-derived small RNAs (tsRNAs) are novel small non-coding RNAs ...