Prasad, Ram R Raina, Komal Mishra, Neha Tomar, Munendra S Kumar, Robin Palmer, Amy E Maroni, Paul Agarwal, Rajesh
Published in
Molecular Carcinogenesis
Prostate cancer (PCa) initiation and progression uniquely modify the prostate milieu to aid unrestrained cell proliferation. One salient modification is the loss of the ability of prostate epithelial cells to accumulate high concentrations of zinc; however, molecular alterations associated with loss of zinc accumulating capability in malignant pros...
Zhang, Jiangbo Jia, Junqiao Zhao, Lijun Li, Xiaojun Xie, Qing Chen, Xiangmei Wang, Jianliu Lu, Fengmin
Published in
Molecular carcinogenesis
MicroRNA-9 (miR-9) presents to exert distinct and even opposite functions in different kinds of tumors through targeting different cellular genes. However, its role in cervical adenocarcinoma remains uncertain. Here, we report that miR-9 is down-regulated in cervical adenocarcinoma due to its frequent promoter-hypermethylation and exerts its tumor ...
Illemann, Martin Eefsen, Rikke Helene Løvendahl Bird, Nigel Charles Majeed, Ali Osterlind, Kell Laerum, Ole Didrik Alpízar-Alpízar, Warner Lund, Ida Katrine Høyer-Hansen, Gunilla
Published in
Molecular carcinogenesis
Metastatic growth by colorectal cancer cells in the liver requires the ability of the cancer cells to interact with the new microenvironment. This interaction results in three histological growth patterns of liver metastases: desmoplastic, pushing, and replacement. In primary colorectal cancer several proteases, involved in the degradation of extra...
Colin-Cassin, Christelle Yao, Xiao Cerella, Claudia Chbicheb, Sarra Kuntz, Sandra Mazerbourg, Sabine Boisbrun, Michel Chapleur, Yves Diederich, Marc Flament, Stephane
...
Published in
Molecular Carcinogenesis
Our aim was to better understand peroxisome proliferator-activated receptor gamma (PPARγ)-independent pathways involved in anti-cancer effects of thiazolidinediones (TZDs). We focused on Δ2-troglitazone (Δ2-TGZ), a PPARγ inactive TZD that affects breast cancer cell viability. Appearance of TUNEL positive cells, changes in mitochondrial membrane pot...
Bana, Emilie Sibille, Estelle Valente, Sergio Cerella, Claudia Chaimbault, Patrick Kirsch, Gilbert Dicato, Mario Diederich, Marc Bagrel, Denyse
Published in
Molecular Carcinogenesis
Cell division cycle (CDC) 25 proteins are key phosphatases regulating cell cycle transition and proliferation by regulating CDK/cyclin complexes. Overexpression of these enzymes is frequently observed in cancer and is related to aggressiveness, high-grade tumors and poor prognosis. Thus, targeting CDC25 by compounds, able to inhibit their activity,...
Poplineau, Mathilde Schnekenburger, Michael Dufer, Jean Kosciarz, Aleksandra Brassart-Pasco, Sylvie Antonicelli, Frank Diederich, Marc Trussardi-Régnier, Aurélie
Published in
Molecular carcinogenesis
In diseases such as cancer, cells need to degrade the extracellular matrix (ECM) and therefore require high protease levels. Thus, aberrant tissue degradation is associated to matrix metalloproteinases (MMPs) overexpression resulting from different mechanisms including epigenetic events. One of the most characterized epigenetic mechanisms is DNA me...
Sobolewski, Cyril Florian Muller Claudia Cerella Dicato, Mario Marc Diederich
Published in
Molecular Carcinogenesis
Molecules targeting pro-inflammatory pathways have demonstrated beneficial effects in cancer treatment. More recently, combination of natural and synthetic anti-inflammatory drugs was suggested as an appealing strategy to inhibit tumor growth. Herein, we show that curcumin, a polyphenol from Curcuma longa and celecoxib induce apoptosis in hematopoi...
PEIXIN DONG Dong, Peixin Kaneuchi, Masanori Watari, Hidemichi Sudo, Satoko Sakuragi, Noriaki
Published in
Molecular Carcinogenesis
Type II endometrial carcinoma is an aggressive subtype of endometrial cancer (EC). TWIST1, a helix-loop-helix transcription regulator, is known to induce epithelial-mesenchymal transition (EMT) and promote tumor metastasis. MicroRNAs (miRNAs) also serve as important regulators of EMT and metastasis by regulating EMT-related genes. In this study, we...
