Okada, Masayasu Kawagoe, Yosuke Sato, Yuta Nozumi, Motohiro Ishikawa, Yuya Tamada, Atsushi Yamazaki, Hiroyuki Sekino, Yuko Kanemura, Yonehiro Shinmyo, Yohei
...
Published in
Molecular Brain
GAP-43 is a vertebrate neuron-specific protein and that is strongly related to axon growth and regeneration; thus, this protein has been utilized as a classical molecular marker of these events and growth cones. Although GAP-43 was biochemically characterized more than a quarter century ago, how this protein is related to these events is still not ...
Lim, Yun Kim, Seolsong Kim, Eun-Kyoung
Published in
Molecular Brain
Palmitate is a saturated fatty acid that is well known to induce endoplasmic reticulum (ER) stress and autophagy. A high-fat diet increases the palmitate level in the hypothalamus, the main region of the brain regulating energy metabolism. Interestingly, hypothalamic palmitate level is also increased under starvation, urging the study to distinguis...
Boccella, Serena Guida, Francesca Iannotta, Monica Iannotti, Fabio Arturo Infantino, Rosmara Ricciardi, Flavia Cristiano, Claudia Vitale, Rosa Maria Amodeo, Pietro Marabese, Ida
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Published in
Molecular Brain
An amendment to this paper has been published and can be accessed via the original article.
Rhee, Jun Kyu Park, Heeyoun Kim, Taegon Yamamoto, Yukio Tanaka-Yamamoto, Keiko
Published in
Molecular Brain
Cerebellar granule cells (GCs) relay mossy fiber (MF) inputs to Purkinje cell dendrites via their axons, the parallel fibers (PFs), which are individually located at a given sublayer of the molecular layer (ML). Although a certain degree of heterogeneity among GCs has been recently reported, variability of GC responses to MF inputs has never been a...
Hori, Tesshu Ikuta, Shohei Hattori, Satoko Takao, Keizo Miyakawa, Tsuyoshi Koike, Chieko
Published in
Molecular Brain
The 15q13.3 microdeletion syndrome is a genetic disorder characterized by a wide spectrum of psychiatric disorders that is caused by the deletion of a region containing 7 genes on chromosome 15 (MTMR10, FAN1, TRPM1, MIR211, KLF13, OTUD7A, and CHRNA7). The contribution of each gene in this syndrome has been studied using mutant mouse models, but no ...
Kim, Kyung-Ran Kim, Yoonsub Jeong, Hyeon-Ju Kang, Jong-Sun Lee, Sang Hun Kim, Yujin Lee, Suk-Ho Ho, Won-Kyung
Published in
Molecular Brain
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that causes memory loss. Most AD researches have focused on neurodegeneration mechanisms. Considering that neurodegenerative changes are not reversible, understanding early functional changes before neurodegeneration is critical to develop new strategies for early detection and tr...
Chen, Qi-Yu Li, Xu-Hui Lu, Jing-Shan Liu, Yinglu Lee, Jung-Hyun Alex Chen, Yu-Xin Shi, Wantong Fan, Kexin Zhuo, Min
Published in
Molecular Brain
IntroductionN-Methyl-D-aspartate receptors (NMDARs) play a critical role in different forms of plasticity in the central nervous system. NMDARs are always assembled in tetrameric form, in which two GluN1 subunits and two GluN2 and/or GluN3 subunits combine together. Previous studies focused mainly on the hippocampus. The anterior cingulate cortex (...
Yokota, Mutsumi Kakuta, Soichiro Shiga, Takahiro Ishikawa, Kei-ichi Okano, Hideyuki Hattori, Nobutaka Akamatsu, Wado Koike, Masato
Published in
Molecular Brain
Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitochondrial structural changes. Parkinson’s disease (PD) with PRKN mutations is characterized by the preferential ...
Kubota, Shun Doi, Hiroshi Koyano, Shigeru Tanaka, Kenichi Komiya, Hiroyasu Katsumoto, Atsuko Ikeda, Shingo Hashiguchi, Shunta Nakamura, Haruko Fukai, Ryoko
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Published in
Molecular Brain
Intracellular aggregates are a common pathological hallmark of neurodegenerative diseases such as polyglutamine (polyQ) diseases, amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and multiple system atrophy (MSA). Aggregates are mainly formed by aberrant disease-specific proteins and are accompanied by accumulation of other aggregate-...
Sowa, Anna S. Popova, Taissia G. Harmuth, Tina Weber, Jonasz J. Pereira Sena, Priscila Schmidt, Jana Hübener-Schmid, Jeannette Schmidt, Thorsten
Published in
Molecular Brain
Spinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disorder resulting from an aberrant expansion of a polyglutamine stretch in the ataxin-3 protein and subsequent neuronal death. The underlying intracellular signaling pathways are currently unknown. We applied the Reverse-phase Protein MicroArray (RPMA) technology to assess the levels...
