Correction to: Pathophysiology of and therapeutic options for a GABRA1 variant linked to epileptic encephalopathy
...Published in Molecular Brain
Following publication of the original article [1], the authors reported errors in Figure 4.
Ascending noradrenergic excitation from the locus coeruleus to the anterior cingulate cortex
...Published in Molecular Brain
Anterior cingulate cortex (ACC) plays important roles in sensory perception including pain and itch. Neurons in the ACC receive various neuromodulatory inputs from subcortical structures, including locus coeruleus noradrenaline (LC-NA) neurons. Few studies have been reported about synaptic and behavioral functions of LC-NA projections to the ACC. U...
Correction to: Optical monitoring of glutamate release at multiple synapses in situ detects changes following LTP induct...
Published in Molecular Brain
In the original publication of this article [1], text has been introduced erroneously to Figs. 4a and 5d due to a typesetting mistake.
Transcriptomic analysis of long noncoding RNAs and mRNAs expression profiles in the spinal cord of bone cancer pain rats...
Published in Molecular Brain
Bone cancer pain (BCP) is one of the most common types of chronic cancer pain and its pathogenesis has not been fully understood. Long non-coding RNAs (lncRNAs) are new promising targets in the field of pain research, however, their involvements in BCP have not been reported. In the present study, we established the BCP model by implantation of Wal...
Aging-related motor function and dopaminergic neuronal loss in C57BL/6 mice
Published in Molecular Brain
Aging-related dopaminergic neuronal loss and its motor phenotypes are well known. Excessive loss of dopaminergic neurons leads to Parkinson’s disease (PD), the most common neurodegenerative disorder characterized by the loss of nigrostriatal dopamine–producing neurons. In mice, however, aging-related dopaminergic neuronal loss and its consequences ...
A mutant vesicular stomatitis virus with reduced cytotoxicity and enhanced anterograde trans-synaptic efficiency
Published in Molecular Brain
Understanding the connecting structure of brain network is the basis to reveal the principle of the brain function and elucidate the mechanism of brain diseases. Trans-synaptic tracing with neurotropic viruses has become one of the most effective technologies to dissect the neural circuits. Although the retrograde trans-synaptic tracing for analyzi...
High frequency optogenetic activation of inputs to the lateral amygdala forms distant association with foot-shock
Published in Molecular Brain
AimA hallmark of classical conditioning is that conditioned stimulus (CS) must be tightly coupled with unconditioned stimulus (US), often requiring temporal overlap between the two, or a short gap of several seconds. In this study, we investigate the temporal requirements for fear conditioning association between a strong artificial CS, high-freque...
Human iPS cell-derived mural cells as an in vitro model of hereditary cerebral small vessel disease
...Published in Molecular Brain
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is one of the most common forms of hereditary cerebral small vessel diseases and is caused by mutations in NOTCH3. Our group has previously reported incorporation of NOTCH3 extracellular domain (N3ECD) in the CADASIL-specific granular osmiophilic ma...
BDNF impact on synaptic dynamics: extra or intracellular long-term release differently regulates cultured hippocampal sy...
Published in Molecular Brain
Brain Derived Neurotrophic Factor (BDNF) signalling contributes to the formation, maturation and plasticity of Central Nervous System (CNS) synapses. Acute exposure of cultured brain circuits to BDNF leads to up-regulation of glutamatergic neuro-transmission, by the accurate tuning of pre and post synaptic features, leading to structural and functi...
Conditional Dnmt3b deletion in hippocampal dCA1 impairs recognition memory
Published in Molecular Brain
AimActive changes in neuronal DNA methylation and demethylation appear to act as controllers of synaptic scaling and glutamate receptor trafficking in learning and memory formation. DNA methyltransferases (DNMTs), including proteins encoded by Dnmt1, Dnmt3a and Dnmt3b, are dominant enzymes carrying out DNA methylation. Our previous study demonstrat...
