Smith, Gilbert Manzano-Marín, Alejandro Reyes-Prieto, Mariana Antunes, Cátia Sofia Ribeiro Ashworth, Victoria Goselle, Obed Nanjul Jan, Abdulhalem Abdulsamad A Moya, Andrés Latorre, Amparo Perotti, M Alejandra
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Published in
Molecular Biology and Evolution
Most humans carry mites in the hair follicles of their skin for their entire lives. Follicular mites are the only metazoans that continuously live on humans. We propose that Demodex folliculorum (Acari) represents a transitional stage from a host-injuring obligate parasite to an obligate symbiont. Here, we describe the profound impact of this trans...
Zhang, Chuanyi Sashittal, Palash Xiang, Michael Zhang, Yichi Kazi, Ayesha El-Kebir, Mohammed
Published in
Molecular Biology and Evolution
Transcription regulatory sequences (TRSs), which occur upstream of structural and accessory genes as well as the 5 ′ end of a coronavirus genome, play a critical role in discontinuous transcription in coronaviruses. We introduce two problems collectively aimed at identifying these regulatory sequences as well as their associated genes. First, we fo...
Schreiber, Mona Gao, Yixuan Koch, Natalie Fuchs, Joerg Heckmann, Stefan Himmelbach, Axel Börner, Andreas Özkan, Hakan Maurer, Andreas Stein, Nils
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Published in
Molecular Biology and Evolution
The genomic landscape of recombination plays an essential role in evolution. Patterns of recombination are highly variable along chromosomes, between sexes, individuals, populations, and species. In many eukaryotes, recombination rates are elevated in sub-telomeric regions and drastically reduced near centromeres, resulting in large low-recombining...
Tian, Shen Monteiro, Antónia
Published in
Molecular biology and evolution
Organisms residing in regions with alternating seasons often develop different phenotypes, or forms, in each season. These forms are often adaptations to each season and result from an altered developmental response to specific environmental cues such as temperature. While multiple studies have examined form-specific gene expression profiles in a d...
Ekkers, David M Tusso, Sergio Moreno-Gamez, Stefany Rillo, Marina C Kuipers, Oscar P van Doorn, G Sander
Published in
Molecular biology and evolution
Mitigating trade-offs between different resource-utilization functions is key to an organism's ecological and evolutionary success. These trade-offs often reflect metabolic constraints with a complex molecular underpinning; therefore, their consequences for evolutionary processes have remained elusive. Here, we investigate how metabolic architectur...
Zuo, Sheng Yadala, Ramakrishna Yang, Fen Talbert, Paul Fuchs, Joerg Schubert, Veit Ahmadli, Ulkar Rutten, Twan Pecinka, Ales Lysak, Martin A
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Published in
Molecular Biology and Evolution
KINETOCHORE NULL2 (KNL2) plays key role in the recognition of centromeres and new CENH3 deposition. To gain insight into the origin and diversification of the KNL2 gene, we reconstructed its evolutionary history in the plant kingdom. Our results indicate that the KNL2 gene in plants underwent three independent ancient duplications in ferns, grasses...
Smith, Megan L Vanderpool, Dan Hahn, Matthew W
Published in
Molecular biology and evolution
Traditionally, single-copy orthologs have been the gold standard in phylogenomics. Most phylogenomic studies identify putative single-copy orthologs using clustering approaches and retain families with a single sequence per species. This limits the amount of data available by excluding larger families. Recent advances have suggested several ways to...
Johri, Parul Gout, Jean-Francois Doak, Thomas G Lynch, Michael
Published in
Molecular biology and evolution
Whole-genome duplications (WGDs) have occurred in many eukaryotic lineages. However, the underlying evolutionary forces and molecular mechanisms responsible for the long-term retention of gene duplicates created by WGDs are not well understood. We employ a population-genomic approach to understand the selective forces acting on paralogs and investi...
Iyengar, Bharat Ravi Wagner, Andreas
Published in
Molecular biology and evolution
Chaperones are proteins that help other proteins fold. They also affect the adaptive evolution of their client proteins by buffering the effect of deleterious mutations and increasing the genetic diversity of evolving proteins. We study how the bacterial chaperone GroE (GroEL+GroES) affects the evolution of green fluorescent protein (GFP). To this ...
Harris, Kurt L Thomson, Raine E S Gumulya, Yosephine Foley, Gabriel Carrera-Pacheco, Saskya E Syed, Parnayan Janosik, Tomasz Sandinge, Ann-Sofie Andersson, Shalini Jurva, Ulrik
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Published in
Molecular biology and evolution
The cytochrome P450 family 1 enzymes (CYP1s) are a diverse family of hemoprotein monooxygenases, which metabolize many xenobiotics including numerous environmental carcinogens. However, their historical function and evolution remain largely unstudied. Here we investigate CYP1 evolution via the reconstruction and characterization of the vertebrate C...