Devoucoux, Maëva Roques, Céline Lachance, Catherine Lashgari, Anahita Joly-Beauparlant, Charles Jacquet, Karine Alerasool, Nader Prudente, Alexandre Taipale, Mikko Droit, Arnaud
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Published in
Molecular & cellular proteomics : MCP
MRG15/MORF4L1 is a highly conserved protein in eukaryotes that contains a chromodomain (CHD) recognizing methylation of lysine 36 on histone H3 (H3K36me3) in chromatin. Intriguingly, it has been reported in the literature to interact with several different factors involved in chromatin modifications, gene regulation, alternative mRNA splicing, and ...
Hammond, Dean E Simpson, Deborah M Franco, Catarina Wright Muelas, Marina Waters, John Ludwig, R W Prescott, Mark C Hurst, Jane L Beynon, Robert J Lau, Edward
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Published in
Molecular & cellular proteomics : MCP
Changes in the abundance of individual proteins in the proteome can be elicited by modulation of protein synthesis (the rate of input of newly synthesized proteins into the protein pool) or degradation (the rate of removal of protein molecules from the pool). A full understanding of proteome changes therefore requires a definition of the roles of t...
Massignani, Enrico Giambruno, Roberto Maniaci, Marianna Nicosia, Luciano Yadav, Avinash Cuomo, Alessandro Raimondi, Francesco Bonaldi, Tiziana
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Molecular & cellular proteomics : MCP
Protein arginine (R) methylation is a post-translational modification involved in various biological processes, such as RNA splicing, DNA repair, immune response, signal transduction, and tumor development. Although several advancements were made in the study of this modification by mass spectrometry, researchers still face the problem of a high fa...
Ochoa-Rios, Shaaron O'Connor, Ian P Kent, Lindsey N Clouse, Julian M Hadjiyannis, Yannis Koivisto, Christopher Pecot, Thierry Angel, Peggi M Drake, Richard R Leone, Gustavo
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Molecular & cellular proteomics : MCP
Nonalcoholic steatohepatitis (NASH) is the progressive form of nonalcoholic fatty liver disease (NAFLD) and is characterized by inflammation, hepatocyte injury, and fibrosis. Further, NASH is a risk factor for cirrhosis and hepatocellular carcinoma. Previous research demonstrated that serum N-glycan profiles can be altered in NASH patients. Here, w...
Jiang, Wei Zhang, Pei Yang, Peng Kang, Na Liu, Junqiang Aihemaiti, Yilixiati Tu, Haijun
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Molecular & cellular proteomics : MCP
Cerebral stroke is one of the leading causes of death in adults worldwide. However, the molecular mechanisms of stroke-induced neuron injury are not fully understood. Here, we obtained phosphoproteomic and proteomic profiles of the acute ischemic hippocampus by LC-MS/MS analysis. Quantitative phosphoproteomic analyses revealed that the dysregulated...
Kongpracha, Pornparn Wiriyasermkul, Pattama Isozumi, Noriyoshi Moriyama, Satomi Kanai, Yoshikatsu Nagamori, Shushi
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Molecular & cellular proteomics : MCP
Membrane proteins play essential roles in various cellular processes, such as nutrient transport, bioenergetic processes, cell adhesion, and signal transduction. Proteomics is one of the key approaches to exploring membrane proteins comprehensively. Bottom-up proteomics using LC-MS/MS has been widely used in membrane proteomics. However, the low ab...
Petralia, Laudine M C van Diepen, Angela Lokker, Lena A Nguyen, D Linh Sartono, Erliyani Khatri, Vishal Kalyanasundaram, Ramaswamy Taron, Christopher H Foster, Jeremy M Hokke, Cornelis H
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Molecular & cellular proteomics : MCP
Millions of people worldwide are infected with filarial nematodes, responsible for lymphatic filariasis (LF) and other diseases causing chronic disablement. Elimination programs have resulted in a substantial reduction of the rate of infection in certain areas creating a need for improved diagnostic tools to establish robust population surveillance...
Gaither, Claudia Popp, Robert Zahedi, René P Borchers, Christoph H
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Molecular & cellular proteomics : MCP
Plasma is an important biofluid for clinical research and diagnostics. In the clinic, unpredictable delays-from minutes to hours-between blood collection and plasma generation are often unavoidable. These delays can potentially lead to protein degradation and modification and might considerably affect intact protein measurement methods such as sand...
Ge, Zhenhuang Yuan, Peibo Chen, Lingming Chen, Junyi Shen, Dong She, Zhigang Lu, Yongjun
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Molecular & cellular proteomics : MCP
Legionella pneumophila, an environmental bacterium that parasitizes protozoa, causes Legionnaires' disease in humans that is characterized by severe pneumonia. This bacterium adopts a distinct biphasic life cycle consisting of a non-virulent replicative phase and a virulent transmissive phase in response to different environmental conditions; Hence...
Yewdell, Jonathan W
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Molecular & cellular proteomics : MCP
In the 35 years since the revelation that short peptides bound to major histocompatibility complex class I and II molecules are the secret of the major histocompatibility complex-restricted nature of T-cell recognition, there has been enormous progress in characterizing the immunopeptidome, the repertoire of peptide presented for immunosurveillance...
