Sobue, Yasumori Kojima, Toshihisa Ito, Hiromu Nishida, Keiichiro Matsushita, Isao Kaneko, Yuko Kishimoto, Mitsumasa Kohno, Masataka Sugihara, Takahiko Seto, Yohei
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Published in
Modern rheumatology
This study aimed to evaluate the impact of exercise therapy on patient-reported outcomes (PROs) in rheumatoid arthritis (RA) as part of the process of updating the 2020 Japanese Guidelines for the management of RA according to the Grading of Recommendations, Assessment, Development, and Evaluation system. We searched PubMed, Japana Centra Revuo Med...
Uemura, Keisuke Hamada, Hidetoshi Ando, Wataru Takao, Masaki Sugano, Nobuhiko
Published in
Modern rheumatology
The CentPillar stem (Stryker Orthopaedics), an anatomical short stem, was designed to match the proximal femoral canal shape in both patients with normal hips and those with developmental dysplasia of the hip (DDH). The long-term outcomes of the CentPillar stem was examined herein. In total, 222 hips that underwent total hip arthroplasty using the ...
Yuce Inel, Tuba Kisa, Pelin Teke Balci, Ali Uslu, Sadettin Arslan, Zumrut Hismi, Burcu Ozturk Ucar, Ulku Arslan, Nur Onen, Fatos Sari, Ismail
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Published in
Modern rheumatology
Ochronotic arthropathy (OcA) refers to excessive homogentisic acid (HGA) deposition in the musculoskeletal system. Our current understanding of OcA is limited, as there are less than a thousand alkaptonuria (AKU) cases reported in the literature. Herein, we investigated the rheumatological manifestations of OcA in a group of adult AKU patients. Adu...
Okuyan, Hamza Malik Begen, Mehmet A
Published in
Modern rheumatology
Familial Mediterranean Fever (FMF) is a hereditary early-onset disease that causes periodical fever attack, excessive release of IL-1β, serositis, arthritis and peritonitis. Genetic analyses conducted on FMF patients (mutated and non-mutated) have highlighted that additional contributing factors such as epigenetics and environment play a role in cl...
Tanaka, Yoshiya Takeuchi, Tsutomu Yamanaka, Hisashi Nanki, Toshihiro Umehara, Hisanori Yasuda, Nobuyuki Tago, Fumitoshi Kitahara, Yasumi Kawakubo, Makoto Torii, Kentaro
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Published in
Modern rheumatology
To evaluate the safety and efficacy of E6011, a novel humanized anti-fractalkine monoclonal antibody, in patients with active rheumatoid arthritis (RA) with an inadequate response to biological disease-modifying antirheumatic drugs (DMARDs). Active RA patients inadequately responding to biological DMARDs were randomly assigned to placebo or E6011 4...
Morinaka, Satoshi Tsuboi, Hiroto Hagiwara, Shinya Sugita, Toshiki Tabuchi, Daiki Sato, Ryota Nishiyama, Taihei Okamoto, Shota Terasaki, Toshihiko Yagishita, Mizuki
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Published in
Modern rheumatology
We compared large vessel vasculitis (LVV) clinical features between age groups. We retrospectively examined clinical features and therapies in 41 LVV patients at our hospital from January 2010 to March 2020. We compared two patient groups, elderly (≥50 years) and young (
Nakano, Kazuhisa Saito, Kazuyoshi Nawata, Aya Hanami, Kentaro Kubo, Satoshi Miyagawa, Ippei Fujino, Yoshihisa Nakayamada, Shingo Tanaka, Yoshiya
Published in
Modern rheumatology
To identify predictive factors for lymphoproliferative disorders (LPDs) that persist after methotrexate (MTX) withdrawal (Persistent-LPD) and the optimal treatment for rheumatoid arthritis (RA) after LPD regression. Among 3666 patients with RA treated with MTX in our department from 2006 to 2017, 26 cases of LPD that regressed after MTX withdrawal ...
Niwamoto, Takafumi Handa, Tomohiro Matsui, Shoko Yamamoto, Hiroshi Yoshifuji, Hajime Abe, Hiroyasu Matsumoto, Hisako Kodama, Yuzo Chiba, Tsutomu Seno, Hiroshi
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Published in
Modern rheumatology
Immunoglobulin G4-related disease (IgG4-RD) is a systemic, multiorgan disease of unknown etiology. We aimed to classify IgG4-RD by a combination pattern of affected organs and identify the clinical features, including the comorbidities of each subgroup. Patients diagnosed with IgG4-RD between April 1996 and June 2018 were enrolled from three instit...
Tanatar, Ayşe Karadağ, Şerife Gül Çakan, Mustafa Sönmez, Hafize Emine Ayaz, Nuray Aktay
Published in
Modern rheumatology
To define the demographic, clinical and genetic features of familial Mediterranean fever (FMF) patients with early disease onset and to compare them with late-onset FMF patients. Patients were divided into two groups according to the age of disease onset: group 1 includes the patients who had their first attack ≤3 years of age; group 2 consisted of...
Takeuchi, Tsutomu Tanaka, Yoshiya Higashitani, Chieri Iwai, Megumi Komatsu, Kanji Akazawa, Rio Lademacher, Christopher
Published in
Modern rheumatology
Many patients with rheumatoid arthritis (RA) are not able to achieve long-term disease remission. This phase 2a study (NCT02884635) evaluated the efficacy, safety, pharmacokinetics, and pharmacodynamics of the novel, oral, gonadotropin-releasing hormone antagonist, ASP1707, in combination with methotrexate (MTX) for treatment of RA. Postmenopausal ...
