Uozumi, Ryo Iguchi, Risa Masuda, Sakiko Nishibata, Yuka Nakazawa, Daigo Tomaru, Utano Ishizu, Akihiro
Published in
Modern rheumatology
Objectives: Intravenous immunoglobulin (IVIG) therapy is effective against some autoimmune diseases. We examined the effects of pharmaceutical immunoglobulins on the development of MPO-ANCA-associated vasculitis (MPO-AAV).Methods: Peripheral blood neutrophils were pretreated with 5 mg/ml sulfo-immunoglobulins (IVIG-S) and then exposed to 100 nM pho...
Eguchi, Katsumi Iwanaga, Masako Terada, Kaoru Aramaki, Toshiyuki Tuji, Yoshiko Kurushima, Shouta Kojima, Kanako Arima, Kazuhiko Iwamoto, Naoki Ichinose, Kunihiko
...
Published in
Modern rheumatology
Objective: Recently, Human T-cell leukemia virus type-1 proviral load (HTLV-1 PVL) has been evaluated as an important predictor of adult T-cell leukemia/lymphoma (ATL) in HTLV-1 carriers. We aimed to evaluate whether HTLV-1 PVL is also important for the development of ATL among HTLV-1-positive patients with rheumatoid arthritis (RA).Methods: We est...
Anno, Shohei Okano, Tadashi Mamoto, Kenji Sugioka, Yuko Takeda, Setsuko Hashimoto, Ayumi Yamashita, Emi Morinaka, Rika Ueda, Hatsue Inui, Kentaro
...
Published in
Modern rheumatology
Objectives: This study aimed to compare median nerve stiffness measured by ultrasound real-time tissue elastography in patients with and without rheumatoid arthritis (RA and non-RA groups, respectively).Methods: Altogether, 402 hands of 201 RA group and 222 hands of 111 non-RA group were included in the study. Ultrasonography was performed to evalu...
Noguchi, Atsushi Yasuda, Shinsuke Hisada, Ryo Kato, Masaru Oku, Kenji Bohgaki, Toshiyuki Suzuki, Miho Matsumoto, Yoshihiro Atsumi, Tatsuya
Published in
Modern rheumatology
Objectives: To analyze the effects of tocilizumab on peripheral B-cell subpopulation and its ability to produce anti-cyclic citrullinated peptide (CCP) antibody in patients with rheumatoid arthritis (RA).Methods: Thirteen consecutive RA patients initiated with tocilizumab were enrolled in our prospective study. Anti-CCP antibody titers and clinical...
Tanaka, Yoshiya Bass, Damon Chu, Myron Egginton, Sally Ji, Beulah Roth, David
Published in
Modern rheumatology
Objectives: To assess the effects of belimumab on disease activity across multiple organ domains in Japanese patients from the Phase 3 randomized, double-blind, North-East Asia study, BEL113750 (NCT01345253).Methods: Patients, aged ≥18 years, with American College of Rheumatology-defined systemic lupus erythematosus (SLE) and a Safety of Estrogen i...
Kameda, Hideto Wada, Kazuteru Takahashi, Yoshinori Hagino, Owen van Hoogstraten, Hubert Graham, Neil Tanaka, Yoshiya
Published in
Modern rheumatology
Objectives: To determine long-term safety and efficacy of sarilumab as monotherapy or with non-methotrexate (MTX) conventional synthetic disease-modifying antirheumatic drugs (csDMARDs) in Japanese patients with active rheumatoid arthritis (RA).Methods: In this double-blind, randomized study (NCT02373202), patients received subcutaneous sarilumab 1...
Li, Yanshan Cui, Xiaomeng Li, Zunzhong Jia, Qian Jiang, Li Zhang, Zhenchun Lu, Qing Wang, Jibo Jiang, Lindi
Published in
Modern rheumatology
Objectives: To investigate associations of serum melatonin with spinal ossification and cytokines in ankylosing spondylitis (AS).Methods: Serum was obtained from 52 AS patients and 25 healthy controls. Melatonin was measured by ELISA kit; bone morphogenetic protein (BMP)-2, dickkopf-related protein (Dkk)-1, IL-1β, IL-6, IL-17 and TNF-α concentratio...
Nozaki, Yuji Inoue, Asuka Kinoshita, Koji Funauchi, Masanori Matsumura, Itaru
Published in
Modern rheumatology
Objectives: We retrospectively evaluated the retention rate and clinical responses following treatment for rheumatoid arthritis (RA) with iguratimod (IGU) vs. salazosulfapyridine (SASP) as the first-line conventional synthetic disease-modifying antirheumatic drug (csDMARD).Methods: We analyzed 197 RA patients who were treated with IGU or SASP as th...
Kaneshiro, Kenta Yoshida, Kohsuke Morii, Kanta Oketani, Yuto Uchida, Koto Yaekura, Arisa Okumura, Ikumi Hashimoto, Teppei Kawasaki, Yoshiko Shibanuma, Nao
...
Published in
Modern rheumatology
Objectives: Rheumatoid Arthritis (RA) is the autoimmune disease representing the circadian variations of symptoms such as morning stiffness of joints or increased production of cytokines around midnight. Clock genes have been reported to affect on the pathogenesis of RA, however, the detailed relation between clock genes and disease activities of R...
Yoshihara, Hiroyuki Sugiura-Ogasawara, Mayumi Kitaori, Tamao Katano, Kinue Ozaki, Yasuhiko
Published in
Modern rheumatology
Objectives: The objective is to evaluate whether danaparoid is effective in improving the live birth rate in patients with obstetric antiphospholipid syndrome (oAPS).Methods: This prospective study included 91 pregnancies of 60 patients with oAPS diagnosed according to criteria of the International Congress on APS. Live birth rates, adverse pregnan...
