Published in Metabolomics
IntroductionBlood-based sample collection is a challenge, and dried blood spots (DBS) represent an attractive alternative. However, for DBSs to be an alternative to venous blood it is important that these samples are able to deliver comparable associations with clinical outcomes. To explore this we looked to see if lipid profile data could be used ...
Published in Metabolomics
IntroductionMultivalent antimicrobial dendrimers are an exciting new system that is being developed to address the growing problem of drug resistant bacteria. Nuclear Magnetic Resonance (NMR) metabolomics is a quantitative and reproducible method for the determination of bacterial response to environmental stressors and for visualization of perturb...
Published in Metabolomics
IntroductionLC–MS based untargeted metabolomics are the main untargeted methods used for juice metabolomics to solve the authentication problem faced in fruit juice industry.ObjectivesTo evaluate the performances of different untargeted metabolomics methods on fruit juices metabolomics and authentication, orange and apple fruit juices were selected...
Published in Metabolomics
IntroductionApplication of metabolomic methods to forensic studies may expand the limits of the post-mortem interval (PMI) estimation, and improve the accuracy of the estimation. To this end, it is important to determine which tissue is the most suitable for analysis, and which compounds are the most promising candidates for PMI estimation.Objectiv...
Published in Metabolomics
IntroductionThe production of high quality and safe food represents a main priority for the agri-food sector in the effort to sustain the exponentially growing human population. Nonetheless, there are major challenges that require the discovery of new, alternative, and improved plant protection products (PPPs). Focusing on fungal plant pathogens, t...
Published in Metabolomics
IntroductionMitochondria represent an important milieu for studying the pathogenesis of several major diseases. The need for organelle-level metabolic resolution exists, as mitochondrial/cytosolic metabolites are often diluted beyond detection limits in complex samples. Compartment-specific studies are still hindered by the lack of efficient, cost-...
Published in Metabolomics
IntroductionAlong the altitude, environmental conditions vary significantly that might influence plant performance and distribution. Adaptation to these changing conditions is a complex biological process that involves reprogramming of genes, proteins and metabolites. The metabolic response of medicinal plants along the altitude has been less explo...
Published in Metabolomics
IntroductionGut microbiota is, along with adipose tissue, recognized as a source for many metabolic and inflammatory disturbances that may contribute to the individual’s state of health.ObjectivesWe investigated in cross-sectional setting the feasibility of utilizing GlycA, a novel low grade inflammatory marker, and traditional low grade inflammato...
Published in Metabolomics
IntroductionLow potassium intake can affect cardiovascular disease (CVD) risk and cardiometabolic risk factors.ObjectiveWe hypothesize that potassium chloride (KCl) supplementation can improve cardiovascular risk metabolomic profile.MethodsIn this secondary analysis of a pilot randomized clinical trial (RCT) of 26 participants with prediabetes rand...
Published in Metabolomics
IntroductionThe metabolic alterations reflecting the influence of prostate cancer cells can be captured through metabolomic profiling.ObjectiveTo characterize the plasma metabolomic profile in prostatic intraepithelial neoplasia (PIN) and prostate cancer (PCa).MethodsMetabolomics analyses were performed in plasma samples from individuals classified...
