Bitencourt, Almir G. V. Goldberg, Johanna Pinker, Katja Thakur, Sunitha B.
Published in
Metabolomics
IntroductionBreast cancer is a heterogeneous disease with different prognoses and responses to systemic treatment depending on its molecular characteristics, which makes it imperative to develop new biomarkers for an individualized diagnosis and personalized oncological treatment. Ex vivo high-resolution magic angle spinning proton magnetic resonan...
Harada-Shoji, Narumi Soga, Tomoyoshi Tada, Hiroshi Miyashita, Minoru Harada, Mutsuo Watanabe, Gou Hamanaka, Yohei Sato, Akiko Suzuki, Takashi Suzuki, Akihiko
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Published in
Metabolomics
IntroductionMetabolomics has recently emerged as a tool for understanding comprehensive tumor-associated metabolic dysregulation. However, only limited application of this technology has been introduced into the clinical setting of breast cancer.ObjectivesThe aim of this study was to determine the feasibility of metabolome analysis using routine CN...
Cheng, Shih-Chun Chen, Kueian Chiu, Chih-Yung Lu, Kuan-Ying Lu, Hsin-Ying Chiang, Meng-Han Tsai, Cheng-Kun Lo, Chi-Jen Cheng, Mei-Ling Chang, Ting-Chang
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Published in
Metabolomics
IntroductionEndometrial cancer (EC) is one of the most common gynecologic neoplasms in developed countries but lacks screening biomarkers.ObjectivesWe aim to identify and validate metabolomic biomarkers in cervicovaginal fluid (CVF) for detecting EC through nuclear magnetic resonance (NMR) spectroscopy.MethodsWe screened 100 women with suspicion of...
Simonato, Manuela Fochi, Igor Vedovelli, Luca Giambelluca, Sonia Carollo, Cristiana Padalino, Massimo Carnielli, Virgilio P. Cogo, Paola
Published in
Metabolomics
IntroductionTransposition of the great arteries (TGA) is a cyanotic congenital heart defect that requires surgical correction, with the use of cardiopulmonary-bypass (CPB), usually within 3 weeks of life. The use of CPB in open heart surgery results in brain hypoperfusion and in a powerful systemic inflammatory response and oxidative stress.Objecti...
Cheong, Bo Eng Ho, William Wing Ho Biddulph, Ben Wallace, Xiaomei Rathjen, Tina Rupasinghe, Thusitha W. T. Roessner, Ute Dolferus, Rudy
Published in
Metabolomics
IntroductionFrost events lead to A$360 million of yield losses annually to the Australian wheat industry, making improvement of chilling and frost tolerance an important trait for breeding.ObjectivesThis study aimed to use metabolomics and lipidomics to explore genetic variation in acclimation potential to chilling and to identify metabolite marker...
Turkoglu, Onur Citil, Ayse Katar, Ceren Mert, Ismail Kumar, Praveen Yilmaz, Ali Uygur, Dilek S. Erkaya, Salim Graham, Stewart F. Bahado-Singh, Ray O.
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Published in
Metabolomics
IntroductionEctopic pregnancy (EP) is a potentially life-threatening condition and early diagnosis still remains a challenge, causing a delay in management leading to tubal rupture.ObjectivesTo identify putative plasma biomarkers for the detection of tubal EP and elucidate altered biochemical pathways in EP compared to intrauterine pregnancies.Meth...
Singh, Manvendra Pratap Saxena, Mona Saimbi, Charanjit S. Siddiqui, Mohammed Haris Roy, Raja
Published in
Metabolomics
IntroductionOral microflora is a well-orchestrated and acts as a sequential defense mechanism for any infection related to oral disease. Chronic periodontitis is a disease of a microbial challenge to symbiosis and homeostasis. Periodontal surgery is the most promising cure with repair process during periodontal regeneration. It has an encouraging o...
Kayser, Brandon D. Prifti, Edi Lhomme, Marie Belda, Eugeni Dao, Maria-Carlota Aron-Wisnewsky, Judith Cotillard, Aurélie Kennedy, Sean P. Pons, Nicolas Le Chatelier, Emmanuelle
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Published in
Metabolomics
IntroductionLow gut microbiome richness is associated with dyslipidemia and insulin resistance, and ceramides and other sphingolipids are implicated in the development of diabetes.ObjectivesDetermine whether circulating sphingolipids, particularly ceramides, are associated with alterations in the gut microbiome among obese patients with increased d...
Song, Seon Beom Park, Jin Sung Chung, Gu June Lee, In Hye Hwang, Eun Seong
Published in
Metabolomics
BackgroundNicotinamide (NAM) is a form of vitamin B3 that, when administered at near-gram doses, has been shown or suggested to be therapeutically effective against many diseases and conditions. The target conditions are incredibly diverse ranging from skin disorders such as bullous pemphigoid to schizophrenia and depression and even AIDS. Similar ...
Boone, Sebastiaan Mook-Kanamori, Dennis Rosendaal, Frits den Heijer, Martin Lamb, Hildo de Roos, Albert le Cessie, Saskia Willems van Dijk, Ko de Mutsert, Renée
Published in
Metabolomics
IntoductionExcess visceral and liver fat are known risk factors for cardiometabolic disorders. Metabolomics might allow for easier quantification of these ectopic fat depots, instead of using invasive and costly tools such as MRI or approximations such as waist circumference.ObjectiveWe explored the potential use of plasma metabolites as biomarkers...
