Huang, Jialing Covic, Marcela Huth, Cornelia Rommel, Martina Adam, Jonathan Zukunft, Sven Prehn, Cornelia Wang, Li Nano, Jana Scheerer, Markus F
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Published in
Metabolites
Biological exploration of early biomarkers for chronic kidney disease (CKD) in (pre)diabetic individuals is crucial for personalized management of diabetes. Here, we evaluated two candidate biomarkers of incident CKD (sphingomyelin (SM) C18:1 and phosphatidylcholine diacyl (PC aa) C38:0) concerning kidney function in hyperglycemic participants of t...
He, Yijie Liu, Yanhong Ji, Peng
Published in
Metabolites
This study explored the metabolomic profiles in ileal mucosa and colon digesta in response to enterotoxigenic Escherichia coli F18 (ETEC) infection and dietary use of probiotics and low-dose antibiotics. Weaned pigs (n = 48, 6.17 ± 0.36 kg body weight) were randomly allotted to one of four treatments. Pigs in the negative control (NC) were fed a ba...
Xu, Jun Liu, Guning Hegde, Sheila M. Palta, Priya Boerwinkle, Eric Gabriel, Kelley P. Yu, Bing
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Metabolites
Habitual physical activity can diminish the risk of premature death. Identifying a pattern of metabolites related to physical activity may advance our understanding of disease etiology. We quantified 245 serum metabolites in 3802 participants from the Atherosclerosis Risk in Communities (ARIC) study using chromatography–mass spectrometry. We regres...
Morgenstern, Jakob Fleming, Thomas Kliemank, Elisabeth Brune, Maik Nawroth, Peter Fischer, Andreas
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Metabolites
Retinoic acids are vitamin A metabolites that have numerous essential functions in humans, and are also used as drugs to treat acne and acute promyelocytic leukemia. All-trans retinoic acid ( at RA) is the major occurring metabolite of retinoic acid in humans. This study provides a sensitive and specific liquid chromatography–tandem mass spectromet...
Schaid, Michael D. Zhu, Yanlong Richardson, Nicole E. Patibandla, Chinmai Ong, Irene M. Fenske, Rachel J. Neuman, Joshua C. Guthery, Erin Reuter, Austin Sandhu, Harpreet K.
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Published in
Metabolites
The transition from β-cell compensation to β-cell failure is not well understood. Previous works by our group and others have demonstrated a role for Prostaglandin EP3 receptor (EP3), encoded by the Ptger3 gene, in the loss of functional β-cell mass in Type 2 diabetes (T2D). The primary endogenous EP3 ligand is the arachidonic acid metabolite prost...
Lamichhane, Santosh Sen, Partho Alves, Marina Amaral Ribeiro, Henrique C. Raunioniemi, Peppi Hyötyläinen, Tuulia Orešič, Matej
Published in
Metabolites
Various studies aiming to elucidate the role of the gut microbiome-metabolome co-axis in health and disease have primarily focused on water-soluble polar metabolites, whilst non-polar microbial lipids have received less attention. The concept of microbiota-dependent lipid biotransformation is over a century old. However, only recently, several stud...
Ueda, Shuji Yamanoue, Minoru Sirai, Yasuhito Iwamoto, Eiji
Published in
Metabolites
Beef from Japanese Black cattle (Japanese Wagyu) is renowned for its flavor characteristics. To clarify the key metabolites contributing to this rich and sweet aroma of beef, an omics analysis combined with GC-olfactometry (GC-O) and metabolomics analysis with gas chromatography–mass spectrometry (GC-MS) were applied. GC-O analysis identified 39 od...
Yamamoto, Taiji Yaku, Keisuke Nakagawa, Takashi
Published in
Metabolites
d -amino acids have distinct roles from their l -enantiomer. In particular, some d -amino acids function as agonists or antagonists of neuronal receptors and are involved in higher brain functions. Thus, it is important to precisely measure the levels of these amino acid enantiomers in cells and tissues. Various quantification methods have been dev...
McCann, Marc R. George De la Rosa, Mery Vet Rosania, Gus R. Stringer, Kathleen A.
Published in
Metabolites
Biomarker discovery and implementation are at the forefront of the precision medicine movement. Modern advances in the field of metabolomics afford the opportunity to readily identify new metabolite biomarkers across a wide array of disciplines. Many of the metabolites are derived from or directly reflective of mitochondrial metabolism. L-carnitine...
Xu, Jiaming Taubert, Stefan
Published in
Metabolites
Biological membranes are not only essential barriers that separate cellular and subcellular structures, but also perform other critical functions such as the initiation and propagation of intra- and intercellular signals. Each membrane-delineated organelle has a tightly regulated and custom-made membrane lipid composition that is critical for its n...
