Hamer, Mark Gale, Catharine R Batty, G David
Published in
Metabolism: clinical and experimental
We aimed to examine the prospective association of diabetes and glycaemic control with COVID-19 hospitalisation in a large community-based cohort study. Participants (N = 337,802, aged 56.4 ± 8.1 yr; 55.1% women) underwent biomedical assessments at baseline as part of the UK Biobank prospective cohort study. The outcome was cases of COVID-19 seriou...
Zhu, Zhaozhong Hasegawa, Kohei Ma, Baoshan Fujiogi, Michimasa Camargo, Carlos A Jr Liang, Liming
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Metabolism: clinical and experimental
We aimed to examine the associations of obesity-related traits (body mass index [BMI], central obesity) and their genetic predisposition with the risk of developing severe COVID-19 in a population-based data. We analyzed data from 489,769 adults enrolled in the UK Biobank-a population-based cohort study. The exposures of interest are BMI categories...
Kim, Joon Young Tfayli, Hala Bacha, Fida Lee, SoJung Gebara, Nour Arslanian, Silva
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Metabolism: clinical and experimental
In obese youth, it is not clear what degree of β-cell impairment translates to glucose dysregulation commensurate with shifts from normal glucose tolerance (NGT) to impaired glucose tolerance (IGT) to type 2 diabetes. We aimed to investigate the quantitative relationship between β-cell (clamp-measured disposition index [DI]) and OGTT glucose area u...
Mosaferchi, Saeedeh Sharif-Paghaleh, Ehsan Mortezapour, Alireza Heidarimoghadam, Rashid
Published in
Metabolism: clinical and experimental
Hussain, Abdulzahra Vasas, Peter El-Hasani, Shamsi
Published in
Metabolism: clinical and experimental
Means, Casey
Published in
Metabolism: clinical and experimental
Rothenbuhler, Anya Schnabel, Dirk Högler, Wolfgang Linglart, Agnès
Published in
Metabolism: clinical and experimental
Early diagnosis, optimal therapeutic management and regular follow up of children with X-linked hypophosphatemia (XLH) determine their long term outcomes and future quality of life. Biochemical screening of potentially affected newborns in familial cases and improving physician's knowledge on clinical signs, symptoms and biochemical characteristics...
Bacchetta, Justine Bardet, Claire Prié, Dominique
Published in
Metabolism: clinical and experimental
Phosphate is a cornerstone of several physiological pathways including skeletal development, bone mineralization, membrane composition, nucleotide structure, maintenance of plasma pH, and cellular signaling. The kidneys have a key role in phosphate homeostasis with three hormones having important functions in renal phosphate handling or intestinal ...
Gurjar, Anagha Ashok Kushwaha, Sapana Chattopadhyay, Sourav Das, Nabanita Pal, Subhashis China, Shyamsundar Pal Kumar, Harish Trivedi, Arun Kumar Guha, Rajdeep Chattopadhyay, Naibedya
...
Published in
Metabolism: clinical and experimental
Skeletal muscle atrophy is characterized by muscle wasting with partial or complete functional loss. Skeletal muscle atrophy severely affects the quality of life and currently, there is no available therapy except for spinal muscular atrophy. Drug repositioning is a promising strategy that reduces cost and time due to prior availability of safety a...
Bjune, Jan-Inge Dyer, Laurence Røsland, Gro V Tronstad, Karl Johan Njølstad, Pål R Sagen, Jørn V Dankel, Simon N Mellgren, Gunnar
Published in
Metabolism: clinical and experimental
Inhibition of Irx3 and Irx5 has been shown to reduce body weight and white adipose tissue (WAT) mass through cell-autonomous and sympathetic-induced increases in adipocyte beiging and thermogenesis in mice and humans. However, the underlying mechanisms of the Irx control over beiging are still largely unknown, as illustrated by recent reports showi...
