COVID-19 editorial: mechanistic links and therapeutic challenges for metabolic diseases one year into the COVID-19 pande...
Published in Metabolism: clinical and experimental
The link between COVID-19 and VItamin D (VIVID): A systematic review and meta-analysis.
Published in Metabolism: clinical and experimental
Disease severity and mortality rates due to COVID-19 infection are greater in the elderly and chronically ill patients, populations at high risk for vitamin D deficiency. Vitamin D plays an important role in immune function and inflammation. This systematic review and meta-analysis assesses the impact of vitamin D status and supplementation on COVI...
Glutamine metabolism: from proliferating cells to cardiomyocytes.
Published in Metabolism: clinical and experimental
Glutamine is a major energy source for rapidly dividing cells, such as hematopoietic stem cells and cancer cells. Reliance on glutamine is therefore regarded as a metabolic hallmark of proliferating cells. Moreover, reprogramming glutamine metabolism by various factors, including tissue type, microenvironment, pro-oncogenes, and tumor suppressor ge...
A requirement for PAK1 to support mitochondrial function and maintain cellular redox balance via electron transport chai...
Published in Metabolism: clinical and experimental
p21 (Cdc42/Rac1) activated Kinase 1 (PAK1) is a candidate susceptibility factor for type 2 diabetes (T2D). PAK1 is depleted in the islets from T2D donors, compared to control individuals. In addition, whole-body PAK1 knock out (PAK1-KO) in mice worsens the T2D-like effects of high-fat diet. The current study tested the effects of modulating PAK1 le...
Elafibranor improves diet-induced nonalcoholic steatohepatitis associated with heart failure with preserved ejection fra...
...Published in Metabolism: clinical and experimental
Cardiovascular disease is the leading cause of deaths in nonalcoholic steatohepatitis (NASH) patients. Mouse models, while widely used for drug development, do not fully replicate human NASH nor integrate the associated cardiac dysfunction, i.e. heart failure with preserved ejection fraction (HFpEF). To overcome these limitations, we established a ...
Mitochondrial dynamics and nonalcoholic fatty liver disease (NAFLD): new perspectives for a fairy-tale ending?
Published in Metabolism: clinical and experimental
Nonalcoholic fatty liver disease (NAFLD) includes a broad spectrum of liver dysfunctions and it is predicted to become the primary cause of liver failure and hepatocellular carcinoma. Mitochondria are highly dynamic organelles involved in multiple metabolic/bioenergetic pathways in the liver. Emerging evidence outlined that hepatic mitochondria ada...
Excess body weight is an independent risk factor for severe forms of COVID-19.
...Published in Metabolism: clinical and experimental
Few studies distinguished the independent role of overweight/obesity or their associated-comorbidities in the evolution towards severe forms of COVID-19. Obesity as a unifying risk factor for severe COVID-19 is an emerging hypothesis. The aim of this study was to evaluate whether excessive body weight per se, was a risk factor for developing a seve...
Making progress towards a better pathophysiological understanding and more promising therapeutic options for treating no...
Published in Metabolism: clinical and experimental
Commentary: COVID-19 and obesity pandemics converge into a syndemic requiring urgent and multidisciplinary action.
Published in Metabolism: clinical and experimental
While substantial evidence points towards obesity and associated cardiometabolic disorders being a major factor for poor outcomes in SARS-CoV2 infections (COVID-19), the complexity of the interplay between these two pandemics is becoming apparent. Indeed, as previously defined, this interaction between obesity and COVID-19 represents a 'syndemic' t...
Mediterranean diet as a nutritional approach for COVID-19.
Published in Metabolism: clinical and experimental
