Hounie, Ana Gabriela Almeida Vasques, Marco Agassiz
Published in
Medical Cannabis and Cannabinoids
Progressive supranuclear palsy (PSP) is a severe, debilitating, and often fatal disease resembling other neurodegenerative disorders, namely Alzheimer’s (AD) and Parkinson’s (PD) diseases, which have been successfully treated with cannabinoids. We herein report the case of a 71-year-old woman diagnosed with PSP, displaying severe impairment of moto...
Espel Grekopoulos, Joan
Published in
Medical Cannabis and Cannabinoids
There is an increasing interest in cannabinoids as they are being proved to effectively treat the symptoms of a variety of medical conditions. Commercialization of cannabinoid-based pharmaceutical products is expected to grow in the near future, favored by the recent changes in medical regulations in many developed countries. Hence, robust and reli...
Luschnig, Petra Schicho, Rudolf
Published in
Medical Cannabis and Cannabinoids
The endocannabinoid system (ECS) is a multifunctional homeostatic system involved in many physiological and pathological conditions. The ligands of the ECS are the endocannabinoids, whose actions are mimicked by exogenous cannabinoids, such as phytocannabinoids and synthetic cannabinoids. Responses to the ligands of the ECS are mediated by numerou...
Uchendu, Esther Lata, Hemant Chandra, Suman Khan, Ikhlas A. ElSohly, Mahmoud A.
Published in
Medical Cannabis and Cannabinoids
Cannabis sativa L. (marijuana or hemp) is recognized worldwide for its psychoactive properties as well as for fiber production. This study focused on the evaluation of 3 droplet vitrification protocols for long-term conservation of shoot tips in liquid nitrogen (LN). Shoot tips (∼0.5 mm) were excised from 3- to 4-week-old in vitro-grown shoots of 3...
Nakano, Yukako Tajima, Masataka Sugiyama, Erika Sato, Vilasinee Hirunpanich Sato, Hitoshi
Published in
Medical Cannabis and Cannabinoids
Background: Cannabidiol (CBD) is highly lipophilic, and its oral bioavailability is known to be very low in humans. In this study, we developed a novel nanoemulsion preparation of CBD (CBD-NE) to improve the poor solubility and absorption of CBD. The pharmacokinetic profiles of CBD in rats were evaluated after oral administrations of CBD oil and CB...
Broers, Barbara Patà, Zacharie Mina, Aline Wampfler, James de Saussure, Christian Pautex, Sophie
Published in
Medical Cannabis and Cannabinoids
Background: Dementia is increasing worldwide. No effective medication is currently available for the treatment of the underlying disease and accompanying behavioral symptoms. Cannabinoids might have a beneficial effect, but clinical studies with (low-dose) synthetic THC have not been conclusive. Objective: To test the acceptability, practical aspec...
Welling, Matthew T. Liu, Lei Hazekamp, Arno Dowell, Ashley King, Graham J.
Published in
Medical Cannabis and Cannabinoids
The plant genus Cannabis is a prolific producer of unique pharmaceutically relevant metabolites, commonly referred to as cannabinoids. Robust and standardised methods for the quantification of cannabinoids within botanical and drug forms is a critical step forward for an emerging Cannabis-based pharmaceutical industry, which is poised for rapid exp...
Hasenoehrl, Carina Feuersinger, David Kienzl, Melanie Schicho, Rudolf
Published in
Medical Cannabis and Cannabinoids
The cannabinoid-responsive G protein-coupled receptor GPR55 and its endogenous ligand L-α-lysophosphatidylinositol (LPI) have been reported to play a role in several cancers. A proliferation-enhancing effect of GPR55 has been described for several cancer cell lines and LPI has been found elevated in cancer patients. The aim of this study was to in...
Szejko, Natalia Jakubovski, Ewgeni Fremer, Carolin Müller-Vahl, Kirsten R.
Published in
Medical Cannabis and Cannabinoids
We present the case of a 12-year-old boy diagnosed with Tourette syndrome, who was successfully treated with a combination of vaporized medicinal cannabis and oral pure tetrahydrocannabinol (THC). Due to severe motor tics resulting in insomnia, the parents – both of whom were medical doctors – decided to initiate treatment with 0.02 g vaporized can...
Elhendawy, Mostafa A. Wanas, Amira S. Radwan, Mohamed M. Azzaz, Nabil A. Toson, ElShahat S. ElSohly, Mahmoud A.
Published in
Medical Cannabis and Cannabinoids
The chemical study of Cannabis sativa roots led to the isolation and identification of 10 compounds. Their chemical structures were unambiguously established on the basis of 1D and 2D NMR spectroscopy and mass spectrometry as friedelan-3-one (1), epifriedelanol (2), β-sitosterol (3), ergost-5-en-3-ol (4), methyl hexadecanoate (5), pentadecanoic aci...
