Puopolo, Tess Liu, Chang Ma, Hang Seeram, Navindra P
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Medical cannabis and cannabinoids
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are two cholinergic enzymes catalyzing the reaction of cleaving acetylcholine into acetate and choline at the neuromuscular junction. Abnormal hyperactivity of AChE and BChE can lead to cholinergic deficiency, which is associated with several neurological disorders including cognitive dec...
Li, Xiaoxue Diviant, Jegason P Stith, Sarah S Brockelman, Franco Keeling, Keenan Hall, Branden Vigil, Jacob M
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Medical cannabis and cannabinoids
We measure for the first time how commercially available Cannabis flower products affect feelings of fatigue. A total of 1,224 people recorded 3,922 Cannabis flower self-administration sessions between June 6, 2016, and August 7, 2019, using the Releaf App. Usage sessions included real-time subjective changes in fatigue intensity levels prior to an...
Zieglgänsberger, Walter Brenneisen, Rudolf Berthele, Achim Wotjak, Carsten T Bandelow, Borwin Tölle, Thomas R Lutz, Beat
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Medical cannabis and cannabinoids
The development of a high-end cannabinoid-based therapy is the result of intense translational research, aiming to convert recent discoveries in the laboratory into better treatments for patients. Novel compounds and new regimes for drug treatment are emerging. Given that previously unreported signaling mechanisms for cannabinoids have been uncover...
Brown, Joshua D Goodin, Amie J
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Medical cannabis and cannabinoids
Lorenzl, Stefan Gottwald, Franz Nistler, Angelika Brehm, Laura Grötsch, Renate Haber, Georg Bremm, Christian Weck, Christiane Trummer, Carina Brand, Werner
...
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Medical Cannabis and Cannabinoids
Introduction A phase I, open-label clinical trial in healthy male subjects was conducted to assess the pharmacokinetic and safety profile of an oromucosal cannabinoid spray (AP701) containing a lipid-based nanoparticular drug formulation standardized to ∆-9-tetrahydrocannabinol (THC). Methods Twelve healthy male subjects received a single dose of A...
Mansell, Holly Quinn, Declan Kelly, Lauren E. Alcorn, Jane
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Medical Cannabis and Cannabinoids
Attention deficit hyperactivity disorder (ADHD) is a chronic neurobehavioral disorder that is highly prevalent in children and adults. An increasing number of patients with ADHD are self-medicating with cannabis, despite a lack of evidence on efficacy and safety. This case report describes 3 males (ages 18, 22, and 23) who have integrated cannabis ...
Filer, Crist N.
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Medical Cannabis and Cannabinoids
Dabiri, Ali E. Kassab, Ghassan S.
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Medical Cannabis and Cannabinoids
Cannabis is currently the most consumed illicit substance in the world, and gradual legalization in the USA makes it important to understand the health consequences of the use of this substance. With growing body of evidence that some cannabis ingredients may be beneficial in various aspects of hemostasis, additional research is clearly needed in v...
Goodin, Amie J. Wilson, Debbie L. Cook, Robert L. Wang, Yan Brown, Joshua Winterstein, Almut G.
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Medical Cannabis and Cannabinoids
The Cannabis Clinical Outcomes Research Conference (CCORC) 2021 was held virtually on April 8 and 9, 2021. The conference was hosted by the Consortium for Medical Marijuana Clinical Outcomes Research, a research organization instituted by the state legislature of Florida in the United States. The inaugural annual CCORC 2021 was organized as a scien...
Peterson, Andrew M. Le, Christine Dautrich, Tyler
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Medical Cannabis and Cannabinoids
Introduction: Current evidence suggests that cannabinoids are safe with minimal side effects and are effective in managing chronic pain. Data also show that medical marijuana (MM) may improve quality of life (QoL) among patients. However, there are little data showing the health-related QoL (HRQoL) benefit in MM patients using it for pain. The purp...
