Bouchnita, Anass Volpert, Vitaly Koury, Mark J Hellander, Andreas
Published in
Mathematical biosciences
Drug resistance (DR) is a phenomenon characterized by the tolerance of a disease to pharmaceutical treatment. In cancer patients, DR is one of the main challenges that limit the therapeutic potential of the existing treatments. Therefore, overcoming DR by restoring the sensitivity of cancer cells would be greatly beneficial. In this context, mathem...
Strandberg, J Rickard Humphreys, Keith
Published in
Mathematical biosciences
Historically, multi-state Markov models have been used to study breast cancer incidence and mammography screening effectiveness. In recent years, more biologically motivated continuous tumour growth models have emerged as alternatives. However, a number of challenges remain for these models to make use of the wealth of information available in larg...
Fimmel, Elena Michel, Christian J Pirot, François Sereni, Jean-Sébastien Strüngmann, Lutz
Published in
Mathematical biosciences
By an extensive statistical analysis in genes of bacteria, archaea, eukaryotes, plasmids and viruses, a maximal C3-self-complementary trinucleotide circular code has been found to have the highest average occurrence in the reading frame of the ribosome during translation. Circular codes may play an important role in maintaining the correct reading ...
Johnston, Barbara M Johnston, Peter R
Published in
Mathematical biosciences
Mathematical modelling is a useful technique to help elucidate the connection between non-transmural ischaemia and ST elevation and depression of the ECG. Generally, models represent non-transmural ischaemia using an ischaemic zone that extends from the endocardium partway to the epicardium. However, recent experimental work has suggested that isch...
Sellinger, Thibaut Müller, Johannes Hösel, Volker Tellier, Aurélien
Published in
Mathematical biosciences
Despite the wealth of empirical and theoretical studies, the origin and maintenance of cooperation is still an evolutionary riddle. In this context, ecological life-history traits which affect the efficiency of selection may play a role despite being often ignored. We consider here species such as bacteria, fungi, invertebrates and plants which exh...
Köhnke, M C Malchow, H
Published in
Mathematical biosciences
Biological invasions have impacts on diverse social, ecological, and economic issues. Among others, invasion success can be determined by epidemiological aspects, intraspecific dynamics as, e.g., Allee effects, and interspecific interactions as, e.g., competition. In this study, a process-based model describing competitive eco-epidemiological dynam...
Sigal, Daniel Przedborski, Michelle Sivaloganathan, Darshan Kohandel, Mohammad
Published in
Mathematical biosciences
The cancer stem cell hypothesis states that tumors are heterogeneous and comprised of several different cell types that have a range of reproductive potentials. Cancer stem cells (CSCs), represent one class of cells that has both reproductive potential and the ability to differentiate. These cells are thought to drive the progression of aggressive ...
Webster, Thomas F Schlezinger, Jennifer J
Published in
Mathematical biosciences
Concentration addition/dose addition (CA) has proved to be a powerful tool for estimating the combined effect of mixtures that act by similar mechanisms. We earlier proposed generalized concentration addition (GCA) to deal with the inability of CA to estimate effects of mixtures above the level of the least efficacious component. GCA requires speci...
Hackney, Michael James, Alex Plank, Michael J
Published in
Mathematical biosciences
Fisheries management strategies in which large fish are selectively targeted and younger, smaller fish are protected can lead to disruption of stocks, truncation of the population size spectrum, and impaired recruitment. Balanced harvesting is an alternative approach, which distributes fishing mortality across a wide range of species and sizes in p...
Zhang, Hui Liang, Yanchun Peng, Cheng Han, Siyu Du, Wei Li, Ying
Published in
Mathematical biosciences
A kind of noncoding RNA with length more than 200 nucleotides named long noncoding RNA (lncRNA) has gained considerable attention in recent decades. Many studies have confirmed that human genome contains many thousands of lncRNAs. LncRNAs play significant roles in many important biological processes, including complex disease diagnosis, prognosis, ...
