Lagarrigue, Sandrine Lorthiois, Matthias Degalez, Fabien Gilot, David Derrien, Thomas
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
Animal genomes are pervasively transcribed into multiple RNA molecules, of which many will not be translated into proteins. One major component of this transcribed non-coding genome is the long non-coding RNAs (lncRNAs), which are defined as transcripts longer than 200 nucleotides with low coding-potential capabilities. Domestic animals constitute ...
Pulido-Quetglas, Carlos Johnson, Rory
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
Human and other genomes encode tens of thousands of long noncoding RNAs (lncRNAs), the vast majority of which remain uncharacterised. High-throughput functional screening methods, notably those based on pooled CRISPR-Cas perturbations, promise to unlock the biological significance and biomedical potential of lncRNAs. Such screens are based on libra...
Kolpa, Heather J Creamer, Kevin M Hall, Lisa L Lawrence, Jeanne B
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
Here we provide a brief review of relevant background before presenting results of our investigation into the interplay between scaffold attachment factor A (SAF-A), chromatin-associated RNAs, and DNA condensation. SAF-A, also termed heterogenous nuclear protein U (hnRNP U), is a ubiquitous nuclear scaffold protein that was implicated in XIST RNA l...
Maquat, Lynne Johnson, Rory Valadkhan, Saba Carninci, Piero
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
Sanbonmatsu, Karissa
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
While long non-coding RNAs are known to play key roles in disease and development, relatively few structural studies have been performed for this important class of RNAs. Here, we review functional studies of long non-coding RNAs and expose the need for high-resolution 3-D structural studies, discussing the roles of long non-coding RNAs in the cell...
Camilleri-Robles, Carlos Amador, Raziel Klein, Cecilia C Guigó, Roderic Corominas, Montserrat Ruiz-Romero, Marina
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
Over the last decade, the increasing interest in long non-coding RNAs (lncRNAs) has led to the discovery of these transcripts in multiple organisms. LncRNAs tend to be specifically, and often lowly, expressed in certain tissues, cell types and biological contexts. Although lncRNAs participate in the regulation of a wide variety of biological proces...
Sun, Yu H Lee, Brent Li, Xin Zhiguo
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
PIWI-interacting RNAs (piRNAs), small noncoding RNAs 24-35 nucleotides long, are essential for animal fertility. They play critical roles in a range of functions, including transposable element suppression, gene expression regulation, imprinting, and viral defense. In mammals, piRNAs are the most abundant small RNAs in adult testes and the only sma...
Mizuno-Iijima, Saori Nakashiba, Toshiaki Ayabe, Shinya Nakata, Hatsumi Ike, Fumio Hiraiwa, Noriko Mochida, Keiji Ogura, Atsuo Masuya, Hiroshi Kawamoto, Shoko
...
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
The RIKEN BioResource Research Center (BRC) was established in 2001 as a comprehensive biological resource center in Japan. The Experimental Animal Division, one of the BRC infrastructure divisions, has been designated as the core facility for mouse resources within the National BioResource Project (NBRP) by the Japanese government since FY2002. Ou...
Ehlich, Hilke Cater, Heather L Flenniken, Ann M Goncalves Da Cruz, Isabelle Mura, Anne-Marie Ntafis, Vasileios Raess, Michael Selloum, Mohammed Stoeger, Claudia Suchanova, Sarka
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Published in
Mammalian genome : official journal of the International Mammalian Genome Society
Improving reproducibility and replicability in preclinical research is a widely discussed and pertinent topic, especially regarding ethical responsibility in animal research. INFRAFRONTIER, the European Research Infrastructure for the generation, phenotyping, archiving, and distribution of model mammalian genomes, is addressing this issue by develo...
Perry, M N Smith, C L
Published in
Mammalian genome : official journal of the International Mammalian Genome Society
In addition to naturally occurring sequence variation and spontaneous mutations, a wide array of technologies exist for modifying the mouse genome. Standardized nomenclature, including allele, transgene, and other mutation nomenclature, as well as persistent unique identifiers (PUID) are critical for effective scientific communication, comparison o...
