Introduction to mammalian genome special issue: the microbiome in human health and disease
Published in Mammalian Genome
34th International mammalian genome conference: meeting overview
Published in Mammalian Genome
The 34th International Mammalian Genome Conference (IMGC) was held in conjunction with The Allied Genetics Conference (TAGC2020). Scientists from more than 30 countries participated in TAGC2020 to share advances in genetics and genomics research across species. The mammalian section, represented mostly by International Mammalian Genome Society (IMG...
SNPs at 3′UTR of APOL1 and miR-6741-3p target sites associated with kidney diseases more susceptible to SARS-COV-2 infec...
...Published in Mammalian Genome
Acute Kidney Injury (AKI) is a common manifestation of COVID-19 and several cases have been reported in the setting of the high-risk APOL1 genotype (common genetic variants). This increases the likelihood that African American people with the high-risk genotype APOL1 are at increased risk for kidney disease in the COVID-19 environment. Single-nucle...
Alternative exon splicing and differential expression in pancreatic islets reveals candidate genes and pathways implicat...
...Published in Mammalian Genome
Type 2 diabetes (T2D) has a strong genetic component. Most of the gene variants driving the pathogenesis of T2D seem to target pancreatic β-cell function. To identify novel gene variants acting at early stage of the disease, we analyzed whole transcriptome data to identify differential expression (DE) and alternative exon splicing (AS) transcripts ...
Mutational analyses of novel rat models with targeted modifications in inflammatory bowel disease susceptibility genes
Published in Mammalian Genome
Mutations and single base pair polymorphisms in various genes have been associated with increased susceptibility to inflammatory bowel disease (IBD). We have created a series of rat strains carrying targeted genetic alterations within three IBD susceptibility genes: Nod2 , Atg16l1 , and Il23r, using CRISPR/Cas9 genome editing technology. Knock-out ...
The microbiome and rodent models of immune mediated diseases
Published in Mammalian Genome
Over the last six decades production of laboratory rodents have been refined with the aim of eliminating all pathogens, which could influence research results. This has, however, also created rodents with little diversity in their microbiota. Until 10 years ago the impact of the microbiota on the outcome of rodent studies was ignored, but today it ...
Nucleotide spacing distribution analysis for human genome
Published in Mammalian Genome
The distribution of nucleotides spacing in human genome was investigated. An analysis of the frequency of occurrence in the human genome of different sequence lengths flanked by one type of nucleotide was carried out showing that the distribution has no self-similar (fractal) structure. The results nevertheless revealed several characteristic featu...
A novel knockout mouse for the small EDRK-rich factor 2 ( Serf2 ) showing developmental and other deficits
...Published in Mammalian Genome
The small EDRK-rich factor 2 (SERF2) is a highly conserved protein that modifies amyloid fibre assembly in vitro and promotes protein misfolding. However, the role of SERF2 in regulating age-related proteotoxicity remains largely unexplored due to a lack of in vivo models. Here, we report the generation of Serf2 knockout mice using an ES cell targe...
Alopecia in Harlequin mutant mice is associated with reduced AIF protein levels and expression of retroviral elements
Published in Mammalian Genome
We investigated the contribution of apoptosis-inducing factor (AIF), a key regulator of mitochondrial biogenesis, in supporting hair growth. We report that pelage abnormalities developed during hair follicle (HF) morphogenesis in Harlequin ( Hq ) mutant mice. Fragility of the hair cortex was associated with decreased expression of genes encoding st...
A scan for genes associated with cancer mortality and longevity in pedigree dog breeds
Published in Mammalian Genome
Selective breeding of the domestic dog ( Canis lupus familiaris ) rigidly retains desirable features, and could inadvertently fix disease-causing variants within a breed. We combine phenotypic data from > 72,000 dogs with a large genotypic dataset to search for genes associated with cancer mortality and longevity in pedigree dog breeds. We validate...
