Vignier, Nicolas Bouchaud, Olivier Angheben, Andrea Bottieau, Emmanuel Calleri, Guido Salas-Coronas, Joaquín Martin, Charlotte Ramos, José Manuel Mechain, Matthieu Rapp, Christophe
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Published in
Malaria Journal
BackgroundEuropean travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac issues, of artenimol (previously dihydroartemisinin)–piperaquine (APQ) Eurartesim® during treatment of uncomplicated imported falciparum malaria ...
Nuel, Grégory Garcia, André
Published in
Malaria Journal
BackgroundDespite many technological advances for malaria parasite detection (e.g. high resolution image acquisition), microscopic reading of thick blood smear (TBS) remains the gold standard. Even though available in low technology environment, the microscopy of TBS is slow and time consuming. Moreover microscopy may induce errors at many levels a...
Sondo, Paul Bihoun, Biebo Tahita, Marc Christian Derra, Karim Rouamba, Toussaint Nakanabo Diallo, Seydou Kazienga, Adama Ilboudo, Hamidou Valea, Innocent Tarnagda, Zekiba
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Published in
Malaria Journal
BackgroundMulti-genotype malaria infections are frequent in endemic area, and people commonly harbour several genetically distinct Plasmodium falciparum variants. The influence of genetic multiplicity and whether some specific genetic variants are more or less likely to invest into gametocyte production is not clearly understood. This study explore...
Yaméogo, Koudraogo Bienvenue Yerbanga, Rakiswendé Serge Ouattara, Seydou Bienvenu Yao, Franck A. Lefèvre, Thierry Zongo, Issaka Nikièma, Frederic Compaoré, Yves Daniel Tinto, Halidou Chandramohan, Daniel
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Published in
Malaria Journal
BackgroundSeasonal malaria chemoprevention (SMC) consists of administration of sulfadoxine-pyrimethamine (SP) + amodiaquine (AQ) at monthly intervals to children during the malaria transmission period. Whether the addition of azithromycin (AZ) to SMC could potentiate the benefit of the intervention was tested through a double-blind, randomized, pla...
Whegang Youdom, Solange Basco, Leonardo K.
Published in
Malaria Journal
Several anti-malarial drugs have been evaluated in randomized clinical trials to treat acute uncomplicated Plasmodium falciparum malaria. The outcome of anti-malarial drug efficacy studies is classified into one of four possible outcomes defined by the World Health Organization: adequate clinical and parasitological response, late parasitological f...
Nhama, Abel Nhamússua, Lídia Macete, Eusébio Bassat, Quique Salvador, Crizolgo Enosse, Sónia Candrinho, Baltazar Carvalho, Eva Nhacolo, Arsénio Chidimatembue, Arlindo
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Published in
Malaria Journal
Background Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether–lumefantrine (AL) and amodiaquine–artesunate (AS–AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo therapeutic efficacy study was conducted. Methods The ...
Nundu, Sabin S. Culleton, Richard Simpson, Shirley V. Arima, Hiroaki Muyembe, Jean-Jacques Mita, Toshihiro Ahuka, Steve Yamamoto, Taro
Published in
Malaria Journal
Background Malaria remains a major public health concern in the Democratic Republic of Congo (DRC), and school-age children are relatively neglected in malaria prevalence surveys and may constitute a significant reservoir of transmission. This study aimed to understand the burden of malaria infections in school-age children in Kinshasa/DRC. Methods...
Anaele, Beverly I. Varshney, Karan Ugwu, Francis S. O. Frasso, Rosemary
Published in
Malaria Journal
Background Female mosquitoes serve as vectors for a host of illnesses, including malaria, spread by the Plasmodium parasite. Despite monumental strides to reduce this disease burden through tools such as bed nets, the rate of these gains is slowing. Ongoing disruptions related to the COVID-19 pandemic may also negatively impact gains. The following...
Mwenda, Mulenga C. Fola, Abebe A. Ciubotariu, Ilinca I. Mulube, Conceptor Mambwe, Brenda Kasaro, Rachael Hawela, Moonga B. Hamainza, Busiku Miller, John M. Carpi, Giovanna
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Published in
Malaria Journal
Background Zambia continues to advance on the path to elimination with significant reductions in malaria morbidity and mortality. Crucial components that have contributed to progress thus far and are necessary for achieving the national malaria elimination goals include properly identifying and treating all malaria cases through accurate diagnosis....
Tungu, Patrick K. Sudi, Wema S. Kaur, Harparkash Magesa, Stephen M. Rowland, Mark
Published in
Malaria Journal
Background Long-lasting efficacy of insecticide-treated nets is a balance between adhesion, retention and migration of insecticide to the surface of netting fibres. ICON® Maxx is a twin-sachet ‘home-treatment kit’ of pyrethroid plus binding agent, recommended by the World Health Organization (WHO) for long-lasting, wash-fast treatment of polyester ...
