Massamba, Laurencie Madamet, Marylin Benoit, Nicolas Chevalier, Alicia Fonta, Isabelle Mondain, Véronique Jeandel, Pierre-Yves Amalvict, Rémy Delaunay, Pascal Mosnier, Joel
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Published in
Malaria Journal
BackgroundThe drug combination atovaquone–proguanil, is recommended for treatment of uncomplicated falciparum malaria in France. Despite high efficacy, atovaquone–proguanil treatment failures have been reported. Resistance to cycloguanil, the active metabolite of proguanil, is conferred by multiple mutations in the Plasmodium falciparum dihydrofola...
Wangdi, Kinley Sarma, Haribondu Leaburi, John McBryde, Emma Clements, Archie C. A.
Published in
Malaria Journal
BackgroundDistrict Health Information Systems 2 (DHIS2) is used for supporting health information management in 67 countries, including Solomon Islands. However, there have been few published evaluations of the performance of DHIS2-enhanced disease reporting systems, in particular for monitoring infectious diseases such as malaria. The aim of this ...
Yaro, Jean Baptiste Ouedraogo, Alphonse Ouedraogo, Z. Amidou Diarra, Amidou Lankouande, Malik Agboraw, Efundem Worrall, Eve Toe, Kobié Hyacinthe Sanou, Antoine Guelbeogo, W. Moussa
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Published in
Malaria Journal
BackgroundProgress in controlling malaria has stalled in recent years. Today the malaria burden is increasingly concentrated in a few countries, including Burkina Faso, where malaria is not declining. A cohort study was conducted to identify risk factors for malaria infection in children in southwest Burkina Faso, an area with high insecticide-trea...
Wilairat, Prapon Auparakkitanon, Saranya
Published in
Malaria Journal
BackgroundWe present two conundra in the biology of intraerythrocytic malaria parasite: how an apparent open parasitophorous duct provide direct access of only a select set of serum proteins to the parasitophorous vacuole, and how proteases mediate membrane lysis to allow merozoite egress.SolutionWe posit the existence of a parasitophorous vacuolar...
Zerdo, Zerihun Bastiaens, Hilde Anthierens, Sibyl Massebo, Fekadu Masne, Matewos Biresaw, Gelila Shewangizaw, Misgun Tunje, Abayneh Chisha, Yilma Yohannes, Tsegaye
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Published in
Malaria Journal
BackgroundMalaria is one of the major causes of morbidity and mortality among school-age children (SAC) in sub-Saharan Africa. SAC account for more than 60% of the reservoir of malaria transmission, but they are given less emphasis in prioritizing malaria prevention interventions. This study was aimed at assessing the ownership of long-lasting inse...
Kotepui, Kwuntida Uthaisar Kotepui, Manas
Published in
Malaria Journal
BackgroundPlasmodium spp. and hepatitis B virus (HBV) are among the most common infectious diseases in underdeveloped countries. This study aimed to determine the prevalence of Plasmodium spp. and HBV co-infection in people living in endemic areas of both diseases and to assess the risk factors related to this co-infection.MethodsThe PubMed, Web of...
Ghoshal, Sharmistha Chowdhury, Pramita Ray, Sanhita Mitra, Mitashree Kanjilal, Sumana Datta Sen, Srikanta Dasgupta, Anjan Kr. Sengupta, Sanghamitra
Published in
Malaria Journal
BackgroundReticulocyte binding protein-like homologs (RHs) are currently being evaluated as anti-erythrocytic stage vaccine targets against Plasmodium falciparum malaria. Present study explores the possible evolutionary drivers shaping the genetic organization of Pfrhs in Indian parasite population. It simultaneously evaluates a putative gain-of-fu...
Heinemann, Melina Phillips, Richard O. Vinnemeier, Christof D. Rolling, Christina C. Tannich, Egbert Rolling, Thierry
Published in
Malaria Journal
BackgroundGhana is among the high-burden countries for malaria infections and recently reported a notable increase in malaria cases. While asymptomatic parasitaemia is increasingly recognized as a hurdle for malaria elimination, studies on asymptomatic malaria are scarce, and usually focus on children and on non-falciparum species. The present stud...
Potluri, Vijay Shandil, Radha K. Gavara, R. Sambasivam, Ganesh Campo, Brice Wittlin, Sergio Narayanan, Shridhar
Published in
Malaria Journal
BackgroundEmergence of anti-malarial drug resistance and perpetual increase in malaria incidence necessitates the development of novel anti-malarials. Histone deacetylases (HDAC) has been shown to be a promising target for malaria, despite this, there are no HDAC inhibitors in clinical trials for malaria treatment. This can be attributed to the poo...
Kucharski, Michal Tripathi, Jaishree Nayak, Sourav Zhu, Lei Wirjanata, Grennady van der Pluijm, Rob W. Dhorda, Mehul Dondorp, Arjen Bozdech, Zbynek
Published in
Malaria Journal
BackgroundSequencing technology advancements opened new opportunities to use transcriptomics for studying malaria pathology and epidemiology. Even though in recent years the study of whole parasite transcriptome proved to be essential in understanding parasite biology there is no compiled up-to-date reference protocol for the efficient generation o...
