Culver, Emma L Bungay, Helen K Betts, Margaret Forde, Colm Buchel, Otto Manganis, Charis Warren, Bryan F Cummings, Jr Fraser Keshav, Satish Travis, Simon P L
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Primary sclerosing cholangitis (PSC) is closely associated with inflammatory bowel disease, particularly ulcerative colitis (UC), with an increased risk of biliary and colorectal malignancy. We sought to clarify the prevalence, characteristics and long-term outcome of sub-clinical PSC diagnosed by magnetic resonance cholangiogram (MRC) in patients ...
Stokman, Geurt van den Hoek, Anita M Denker Thorbekk, Ditte Pieterman, Elsbet J Veidal, Sanne Skovgård Basta, Brittany Iruarrizaga-Lejarreta, Marta van der Hoorn, José W Verschuren, Lars Berbée, Jimmy F P
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Whilst fibrosis stage predicts liver-associated mortality, cardiovascular disease (CVD) is still the major overall cause of mortality in patients with NASH. Novel NASH drugs should thus ideally reduce both liver fibrosis and CVD. Icosabutate is a semi-synthetic, liver-targeted eicosapentaenoic acid (EPA) derivative in clinical development for NASH....
van Munster, Kim N Dijkgraaf, Marcel G W van Gennep, Sara Beuers, Ulrich Ponsioen, Cyriel Y
Published in
Liver international : official journal of the International Association for the Study of the Liver
Measuring symptoms and disease burden in patients with primary sclerosing cholangitis (PSC) is increasingly important for daily practice and clinical trials. The Simple Cholestatic Complaints Score (SCCS) is a 4-item questionnaire, that measures cholestatic symptoms (pruritus, fatigue, RUQ abdominal pain and fever) in PSC patients. The aim of this ...
Deltenre, Pierre Trépo, Eric Fujiwara, Naoto Goossens, Nicolas Marot, Astrid Dubois, Margaux Spahr, Laurent Henrion, Jean Moreno, Christophe Hoshida, Yujin
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Published in
Liver international : official journal of the International Association for the Study of the Liver
The gene-signature-model for end stage liver disease (gs-MELD) score has been shown to be a strong predictor of 6-month survival in severe alcoholic hepatitis (AH). Currently, only a few studies have evaluated the long-term prognosis of patients with severe AH. To assess the prognostic value of the gs-MELD score at 5 years in patients with severe A...
Jiang, Dong Zeng, Hui Wang, Xianbo
Published in
Liver international : official journal of the International Association for the Study of the Liver
We thank Zheng et al for their interest in our recent study (1, 2). First, our and others' study did not identify identical TDF-resistant mutants. Firstly, more mutations were need to hurdle higher genetic barrier. HBV is easy to develop resistant mutation for LAM with low genetic barrier, all LAM resistant mutants contain mutation of rtM204. Where...
Hatzakis, Angelos Lazarus, Jeffrey V Cholongitas, Evangelos Baptista-Leite, Ricardo Boucher, Charles Busoi, Cristian-Silviu Deuffic-Burban, Sylvie Chhatwal, Jagpreet Esmat, Gamal Hutchinson, Sharon
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Published in
Liver international : official journal of the International Association for the Study of the Liver
The majority of people infected with chronic hepatitis C virus (HCV) in the European Union (EU) remain undiagnosed and untreated. During recent years, immigration to EU has further increased HCV prevalence. It has been estimated that, out of the 4.2 million adults affected by HCV infection in the 31 EU/ European Economic Area (EEA) countries, as ma...
Papaluca, Timothy Sinclair, Marie Gow, Paul Pianko, Stephen Sievert, William Arachchi, Niranjan Cameron, Karla Bowden, Scott O'Keefe, Jacinta Doyle, Joseph
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Despite highly effective direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection, some patients experience virological relapse. Salvage regimens should include multiple agents to suppress emergence of resistance-associated substitutions (RAS) and minimise treatment failure. The combination of sofosbuvir (SOF) and elbas...
Latham, Ned H Doyle, Joseph S Palmer, Anna Y Vanhommerig, Joost W Agius, Paul Goutzamanis, Stelliana Li, Zinia Pedrana, Alisa Gottfredsson, Magnus Bouscaillou, Julie
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Direct-acting antivirals (DAAs) are highly effective in treating hepatitis C. However, there is concern that cure rates may be lower, and reinfection rates higher, among people who inject drugs. We conducted a systematic review of treatment outcomes achieved with DAAs in people who inject drugs (PWID). A search strategy was used to identify studies...
Bartlett, Sofia R Yu, Amanda Chapinal, Nuria Rossi, Carmine Butt, Zahid Wong, Stanley Darvishian, Maryam Gilbert, Mark Wong, Jason Binka, Mawuena
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Population-level monitoring of hepatitis C virus (HCV) infected people across cascades of care identifies gaps in access and engagement in care and treatment. We characterized the population-level care cascade for HCV in British Columbia (BC), Canada before and after introduction of Direct Acting Antiviral (DAA) treatment. BC Hepatitis Testers Coho...
Ortiz, Guillermo A Sayyar, Mubarak Garcia-Tsao, Guadalupe
Published in
Liver international : official journal of the International Association for the Study of the Liver
