Deltenre, Pierre Trépo, Eric Fujiwara, Naoto Goossens, Nicolas Marot, Astrid Dubois, Margaux Spahr, Laurent Henrion, Jean Moreno, Christophe Hoshida, Yujin
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Published in
Liver international : official journal of the International Association for the Study of the Liver
The gene-signature-model for end stage liver disease (gs-MELD) score has been shown to be a strong predictor of 6-month survival in severe alcoholic hepatitis (AH). Currently, only a few studies have evaluated the long-term prognosis of patients with severe AH. To assess the prognostic value of the gs-MELD score at 5 years in patients with severe A...
Jiang, Dong Zeng, Hui Wang, Xianbo
Published in
Liver international : official journal of the International Association for the Study of the Liver
We thank Zheng et al for their interest in our recent study (1, 2). First, our and others' study did not identify identical TDF-resistant mutants. Firstly, more mutations were need to hurdle higher genetic barrier. HBV is easy to develop resistant mutation for LAM with low genetic barrier, all LAM resistant mutants contain mutation of rtM204. Where...
Hatzakis, Angelos Lazarus, Jeffrey V Cholongitas, Evangelos Baptista-Leite, Ricardo Boucher, Charles Busoi, Cristian-Silviu Deuffic-Burban, Sylvie Chhatwal, Jagpreet Esmat, Gamal Hutchinson, Sharon
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Published in
Liver international : official journal of the International Association for the Study of the Liver
The majority of people infected with chronic hepatitis C virus (HCV) in the European Union (EU) remain undiagnosed and untreated. During recent years, immigration to EU has further increased HCV prevalence. It has been estimated that, out of the 4.2 million adults affected by HCV infection in the 31 EU/ European Economic Area (EEA) countries, as ma...
Papaluca, Timothy Sinclair, Marie Gow, Paul Pianko, Stephen Sievert, William Arachchi, Niranjan Cameron, Karla Bowden, Scott O'Keefe, Jacinta Doyle, Joseph
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Despite highly effective direct-acting antiviral (DAA) therapies for chronic hepatitis C virus (HCV) infection, some patients experience virological relapse. Salvage regimens should include multiple agents to suppress emergence of resistance-associated substitutions (RAS) and minimise treatment failure. The combination of sofosbuvir (SOF) and elbas...
Latham, Ned H Doyle, Joseph S Palmer, Anna Y Vanhommerig, Joost W Agius, Paul Goutzamanis, Stelliana Li, Zinia Pedrana, Alisa Gottfredsson, Magnus Bouscaillou, Julie
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Direct-acting antivirals (DAAs) are highly effective in treating hepatitis C. However, there is concern that cure rates may be lower, and reinfection rates higher, among people who inject drugs. We conducted a systematic review of treatment outcomes achieved with DAAs in people who inject drugs (PWID). A search strategy was used to identify studies...
Bartlett, Sofia R Yu, Amanda Chapinal, Nuria Rossi, Carmine Butt, Zahid Wong, Stanley Darvishian, Maryam Gilbert, Mark Wong, Jason Binka, Mawuena
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Population-level monitoring of hepatitis C virus (HCV) infected people across cascades of care identifies gaps in access and engagement in care and treatment. We characterized the population-level care cascade for HCV in British Columbia (BC), Canada before and after introduction of Direct Acting Antiviral (DAA) treatment. BC Hepatitis Testers Coho...
Ortiz, Guillermo A Sayyar, Mubarak Garcia-Tsao, Guadalupe
Published in
Liver international : official journal of the International Association for the Study of the Liver
Shili-Masmoudi, Sarah Wong, Grace Lai-Hung Hiriart, Jean-Baptiste Liu, Ken Chermak, Faiza Shu, Sally She-Ting Foucher, Juliette Tse, Yee-Kit Bernard, Pierre-Henri Yip, Terry Cheuk-Fung
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Published in
Liver international : official journal of the International Association for the Study of the Liver
In non-alcoholic fatty liver disease (NAFLD), fibrosis is the strongest prognostic factor and can be assessed by non-invasive methods. We evaluated the ability of liver stiffness measurement (LSM) to predict overall survival and liver, cardiovascular and oncologic complications. We prospectively collected data on 2251 consecutive NAFLD patients (me...
Rinker, Franziska Bremer, Corinna M Schröder, Kathrin Wiegand, Steffen B Bremer, Birgit Manns, Michael P Kraft, Anke R Wedemeyer, Heiner Yang, Lei Pavlovic, Vedran
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Published in
Liver international : official journal of the International Association for the Study of the Liver
Hepatitis B virus (HBV) contains three viral surface proteins, large, middle and small hepatitis B surface protein (LHBs, MHBs, SHBs). Proportions of LHBs and MHBs are lower in patients with inactive versus active chronic infection. Interferon alfa may convert HBeAg-positive chronic hepatitis B (CHB) to an inactive carrier state, but prediction of ...
Schreiner, Philipp Stieger, Bruno McLin, Valérie Rougemont, Anne-Laure Keitel, Verena Dröge, Carola Müllhaupt, Beat
Published in
Liver international : official journal of the International Association for the Study of the Liver
We report an unusual case of intermittent episodes of cholestasis in a young patient. The cholestatic attacks were preceded in each case by an infection and subsequent antibiotic therapies. After ruling out many possible causes of cholestatic hepatitis, the differential diagnoses were a benign recurrent intrahepatic cholestasis or a drug-induced li...
