Schreiner, Andrew D Zhang, Jingwen Moran, William P Koch, David G Marsden, Justin Livingston, Sherry Mauldin, Patrick D Gebregziabher, Mulugeta
Published in
Liver international : official journal of the International Association for the Study of the Liver
The Fibrosis-4 index (FIB-4) can reliably assess fibrosis risk in patients with chronic liver disease, and advanced fibrosis is associated with severe liver disease (SLD) outcomes. However, CLD is underdiagnosed in primary care. We examined the association between FIB-4 risk strata and the incidence of SLD preceding a CLD diagnosis while considerin...
Kim, Donghee Dennis, Brittany B Wijarnpreecha, Karn Cholankeril, George Ahmed, Aijaz
Published in
Liver international : official journal of the International Association for the Study of the Liver
Larrey, Dominique D'Erasmo, Laura O'Brien, Sallyann Arca, Marcello
Published in
Liver international : official journal of the International Association for the Study of the Liver
Lomitapide is a microsomal triglyceride transfer protein inhibitor for patients with homozygous familial hypercholesterolaemia. Due to its mechanism of action, potential hepatic effects of lomitapide are of clinical interest. This study aimed to determine the long-term hepatic safety of lomitapide. Data were aggregated from the pivotal phase 3 and ...
Yan, Hualin Du, Lanxin Zheng, Tianying Liu, Juxian
Published in
Liver international : official journal of the International Association for the Study of the Liver
Larrey, Edouard Campion, Bertille Evain, Manon Sultanik, Philippe Blaise, Lorraine Giudicelli, Héloïse Wagner, Mathilde Cluzel, Philippe Rudler, Marika Ganne-Carrié, Nathalie
...
Published in
Liver international : official journal of the International Association for the Study of the Liver
Atezolizumab-bevacizumab is the new standard for advanced hepatocellular carcinoma (HCC) but its impact on portal hypertension (PHT) is unknown. We aimed to identify predictive factors of acute variceal bleeding (AVB) and to monitor PHT parameters under treatment. We conducted a prospective study including all cirrhotic patients treated with atezol...
Ni, Xi Xi Ji, Pei Xuan Chen, Yu Xin Li, Xiao Yun Sheng, Li Lian, Min Guo, Can Jie Hua, Jing
Published in
Liver international : official journal of the International Association for the Study of the Liver
Macrophages display remarkable plasticity and can interact with surrounding cells to affect hepatic immunity and tissue remodelling during the progression of liver diseases. Peroxisome proliferator-activated receptor gamma (PPARγ) plays a critical role in macrophage maturation, polarization and metabolism. In this study, we investigated the role of...
Jeon, Dongsub Song, Gi-Won Lee, Han Chu Shim, Ju Hyun
Published in
Liver international : official journal of the International Association for the Study of the Liver
There are no established practice guidelines for treating hepatocellular carcinoma (HCC) in patients with Child-Turcotte-Pugh (CTP) class B liver function. To evaluate the impact of various initial treatment modalities on these patients, we conducted a nationwide registry study in Korea. Treatment patterns and overall survival (OS) of patients with...
Franchellucci, Gianluca Terrin, Maria Aghemo, Alessio Pugliese, Nicola
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Liver international : official journal of the International Association for the Study of the Liver
He, He Liao, Shenling Zeng, Yuping Liang, Libo Chen, Jie Tao, Chuanmin
Published in
Liver international : official journal of the International Association for the Study of the Liver
Dysregulated iron homeostasis plays an important role in the hepatic manifestation of metabolic-associated fatty liver disease (MAFLD). We investigated the causal effects of five iron metabolism markers, regular iron supplementation and MAFLD risk. Genetic summary statistics were obtained from open genome-wide association study databases. Two-sampl...
Olthof, Pim B Buettner, Stefan Schadde, Erik
Published in
Liver international : official journal of the International Association for the Study of the Liver
