Liu, Zhi He, He Dai, Yuzhao Yang, Lidan Liao, Shenling An, Zhenmei Li, Shuangqing
Published in
Lipids in Health and Disease
Background The triglyceride and glucose index (TyG) and triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) are substitute markers of insulin resistance (IR). In a retrospective cross-sectional study, the authors aimed to compare the efficacy of the two indicators in diagnosing metabolic-associated fatty liver disease (MAFLD) to c...
Wang, Yifen Zhang, Jie Chu, Xueru Wang, Mengke Xin, Yongning Liu, Shousheng
Published in
Lipids in health and disease
MicroRNAs (MiRNAs) are known to participate in preadipocyte differentiation, but the manner in which miR-146a-5p participates in this process remains unclear. This study was performed to examine the participation of miR-146a-5p in 3T3-L1 cell differentiation. miR-146a-5p expression was upregulated and down-regulated to examine effects on 3T3-L1 cel...
Rideout, Todd C. Wen, Xiaozhong Choudhary, Divya Catanzaro, Marissa Browne, Richard W. Barnabei, Vanessa M. Kong, Kai Ling
Published in
Lipids in Health and Disease
Background An excessive rise in maternal lipids during pregnancy may have detrimental impacts on maternal and fetal health leading to adverse pregnancy outcomes. However, knowledge gaps exist with respect to the association between lipid biomarkers and birth outcomes. Methods We conducted a secondary data analysis of healthy pregnant women ( N = 25...
Zeng, Yunqing Cao, Ruyue Tao, Ziwen Gao, Yanjing
Published in
Lipids in Health and Disease
Background The severity of metabolic dysfunction-associated fatty liver disease (MAFLD) reportedly plays a part in the etiology of colorectal tumors. However, there is no consensus. Methods Studies relevant with the impact of MAFLD severity on the risk of colorectal neoplasms published before 24th April 2022 were screened. The pooled odds ratio (OR...
Gil-Acevedo, LA Ceballos, Guillermo Torres-Ramos, YD
Published in
Lipids in Health and Disease
Preeclampsia (PE) is a multisystemic syndrome specific to pregnancy. Although PE is the leading cause of death from complications associated with pregnancy, its aetiology is still unknown. In PE, lipid metabolism is altered. When lipids are damaged, both the mother and the foetus may be at risk. Lipoproteins contain apolipoproteins, triacylglycerol...
Yang, Ming Xu, Yaqin Hu, Chong Zhang, Shuhua Kuang, Maobin Zou, Yang
Published in
Lipids in Health and Disease
Background Hypertriglyceridemic-waist (HTGW) phenotype has been proposed as a practical tool for screening the risk of cardiovascular diseases and glycemic metabolic disease. This study sought to investigate the relationship between HTGW phenotype and non-alcoholic fatty liver disease (NAFLD). Methods A total of 14,251 subjects who took part in hea...
Dong, Xiuli Pan, Shuang Zhang, Daguan Hong, Wandong Chen, Tanzhou Zhang, Bingxin Huang, Zhiming Chen, Chengshui
Published in
Lipids in health and disease
The association of serum triglyceride (TG) levels with the severity of hypertriglyceridaemia-induced acute pancreatitis (HTG-AP) remains controversial. This study aimed to comprehensively assess the TG levels from the initial onset and their predictive value in the disease assessment of HTG-AP. Data collected from January 2018 to July 2021 in one i...
Cheng, Wenke Rosolowski, Maciej Boettner, Julia Desch, Steffen Jobs, Alexander Thiele, Holger Buettner, Petra
Published in
Lipids in health and disease
The preventive effect of cholesterol efflux capacity (CEC) on the progression of atherosclerotic lesions has been confirmed in animal models, but findings in the population are inconsistent. Therefore, this meta-analysis aimed to systematically investigate the relationship of CEC with coronary artery disease (CAD) and cardiovascular mortality in a ...
Hafiane, Anouar Favari, Elda Bortnick, Anna E
Published in
Lipids in health and disease
Calcification of the aortic valve is a common heart valve disorder, in some cases leading to clinically impactful severe aortic stenosis (AS). Sex-specific differences in aortic valve calcification (ACV) exist, with women having a lower burden of calcification than men as measured by computed tomography; however, the pathophysiological mechanism th...
Lu, Hong Lei, Xiaohong Winkler, Rebecca John, Savio Kumar, Devendra Li, Wenkuan Alnouti, Yazen
Published in
Lipids in Health and Disease
Background Hepatocyte nuclear factor 4α (HNF4α) and glucocorticoid receptor (GR), master regulators of liver metabolism, are down-regulated in fatty liver diseases. The present study aimed to elucidate the role of down-regulation of HNF4α and GR in fatty liver and hyperlipidemia. Methods Adult mice with liver-specific heterozygote (HET) and knockou...
