Sun, Dai-Yu Wu, Jia-Qi He, Zhi-Heng He, Ming-Fang Sun, Hong-Bin
Published in
Life sciences
Prostate cancer (PCa) incidence rates are rising in China currently. Cancer-associated fibroblasts (CAFs), as a major component of tumor microenvironment, are crucial for tumor progression. This study was aimed to explore the promotion effect of patient-derived CAFs on the proliferation and migration of prostate cancer cells. CAFs were isolated fro...
Wei, Bin Deng, Yan Huang, Yanlan Gao, Xingcui Wu, Weifeng
Published in
Life sciences
This work aimed to evaluate the regulatory function of IL-10-producing B cells in viral myocarditis (VMC). We adoptively transferred purified IL-10-producing B cells to VMC mice via the tail vein. We observed the inflammatory responses and cardiac lesions by histological analysis, examined the proportions of spleen Th1 and T17 cells by flow cytomet...
Warnement, Catherine M Cismowski, Mary J Rogers, Lynette K
Published in
Life sciences
MicroRNAs (miRs) and their importance in development, normal physiology, and disease have become increasingly recognized. Our laboratory is interested in miR-29 and its effects on lung development. These studies set out to identify optimal conditions for the measurement of miR-29 in heparinized, biobanked samples and to compare isoform expression p...
Ding, Jingjing Li, Fang Cong, Yanfei Miao, Jianing Wu, Di Liu, Bo Wang, Lili
Published in
Life sciences
It is well known that cigarette smoke (CS) is the main risk factor for chronic obstructive pulmonary disease (COPD) accompanied by skeletal muscle atrophy. Histone deacetylases (HDACs) that remove acetyl groups from target proteins are necessary for the muscle atrophy associated with skeletal muscle disuse. However, the role of HDACs and trichostat...
Guan, Xueying Li, Xiaolei Yang, Xuejiao Yan, Junwei Shi, Pilong Ba, Lina Cao, Yonggang Wang, Peng
Published in
Life sciences
Cerebral ischemia is the most common type of neuronal injury and is characterized by a reduction in the function and number of hippocampal neurons. Carvacrol has a significant neuroprotective effect in cerebral ischemia. However, the mechanisms by which carvacrol affects cerebral ischemia, especially with respect to the regulation of neuronal damag...
Sharma, Nisha Malek, Vajir Mulay, Shrikant R Gaikwad, Anil Bhanudas
Published in
Life sciences
Depressor arm of the renin-angiotensin system (RAS) exerts reno-protective effects in chronic kidney diseases like diabetic nephropathy. However, same is still elusive under AKI and hyperglycaemia comorbidity. Hence, the present study delineates the role of angiotensin-II type 2 receptor (AT2R) and angiotensin-converting enzyme 2 (ACE2) in AKI unde...
Sun, Lili Zhang, Junjian Li, Yunwei
Published in
Life sciences
Dysregulation of miR-29 has been revealed in multiple diseases, but its role in the development of hypertension and vascular endothelial dysfunction has not been defined. Here, we found that, compared with the wild-type (WT) Wistar rats, miR-29b was robustly upregulated in spontaneously hypertensive rats (SHRs), while CTRP6 was distinctly downregul...
Dos Santos, Giulia Fonseca Veras, Allice Santos Cruz de Freitas, Marcelo Conrado McCabe, James Seraphim, Patrícia Monteiro Teixeira, Giovana Rampazzo
Published in
Life sciences
Obesity has a positive relation to non-alcoholic fatty liver disease (NAFLD) and studies have demonstrated that strength training can regulate lipid accumulation in the hepatocytes of obese rats. Our aim is to evaluate the effects of high fat diet and strength training on markers of oxidation and lipogenesis in the liver of Wistar rats. Forty Wista...
He, Tao Cui, Jie Wu, Yunhua Sun, Xuejun Chen, Nanzheng
Published in
Life sciences
Colorectal cancer (CRC) is one of the most common malignancies in the world. Emerging evidence has shown that dysregulation of tripartite motif (TRIM) family proteins is strongly correlated with the tumorigenesis of CRC. Here, we evaluated the biological roles of TRIM66, a member of TRIM family, in the progression of CRC. The results demonstrated t...
Mansoor, Sahar Rostami Zabihi, Ebrahim Ghasemi-Kasman, Maryam
Published in
Life sciences
Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the central nervous system (CNS). In attempt to identify an appropriate treatment for improving the neurological symptoms and remyelination process, autologous and allogenic transplantation of mesenchymal stem cells (MSCs) have been introduced as an effective therapeutic strate...
