Lu, Xiaoyan Gan, Quan Gan, Caibin Zheng, Yunpeng Cai, Bingjie Li, Xuyang Li, Dongqin Yin, Guangwen
Published in
Life sciences
The purpose of this study was to explore the precise role and mechanism of p38 inhibiting cutaneous squamous cell carcinoma associated lincRNA (PICSAR) in CSCC. The expression levels of PICSAR, microRNA-125b (miR-125b) and yes-associated protein1 (YAP1) were determined by quantitative real-time polymerase chain reaction (qRT-PCR). Cell proliferatio...
Rikhtegar, Reza Mosimann, Pascal J Rothaupt, Jan Mirza-Aghazadeh-Attari, Mohammad Hallaj, Shahin Yousefi, Mehdi Amiri, Atefeh Farashi, Ebrahim Kheyrollahiyan, Atefeh Dolati, Sanam
...
Published in
Life sciences
Intracranial aneurysm (IA) is one of the most challenging vascular lesions in the brain for clinicians. It was reported that 1%-6% of the world's population is affected by IAs. Owing to serious complications arising from these lesions, much attention has been paid to better understand their pathophysiology. Non-coding RNAs including short non-codin...
Qi, Renli Han, Xu Wang, Jing Qiu, Xiaoyu Wang, Qi Yang, Feiyun
Published in
Life sciences
Accumulating evidence indicates that a number of microRNAs (miRNAs) serve as essential regulators during adipogenesis and adipolysis in humans and animals and play critical roles in the development of fat tissue. In this study, we aimed to determine the functional role and underlying regulatory mechanism of microRNA-489-3p (miR-489) in adipocytes. ...
Zhang, Rui Wang, Ye Hua Shi, Xin Ji, Jiang Zhan, Fu Qin Leng, Hong
Published in
Life sciences
Sortilin is found to regulate proliferation and death of different cells, while its role in regulating keratinocyte proliferation and apoptosis is still unknown. In this study, we found that sortilin levels significantly increased in psoriasis patients, and sortilin suppression eliminated the proliferation of HaCaT cells induced by M5 cocktail solu...
Liu, Qinxin Wang, Yuchang Zheng, Qiang Dong, Xijie Xie, Zhenxing Panayi, Adriana Bai, Xiangjun Li, Zhanfei
Published in
Life sciences
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. The majority of sepsis-related deaths occur during late sepsis, which presents as a state of immunosuppression. Myeloid-derived suppressor cells (MDSCs) have been reported to promote immunosuppression during sepsis. Here we aim to understand...
Habib, Heba A Heeba, Gehan H Khalifa, Mohamed M A
Published in
Life sciences
Diabetic nephropathy, a major threat to diabetic patients, is considered as the main reason for end-stage renal disease. Fortunately, incretin-based therapy has been aroused as considerable source to attenuate diabetic renal damage. This study aimed to investigate whether superior protective effects on the progression of diabetic kidney are exerted...
Zhou, Yue-Tao Chen, Hong Ai, Min Li, Shuang-Shuang Li, Bo-Yan Zhao, Ye Cai, Wei-Wei Hou, Bao Ni, Lu-Lu Xu, Fei
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Published in
Life sciences
SLC9A1 plays an important role in the growth, differentiation and glycolysis of tumor cells. The present study aimed to elucidate the correlation between SLC9A1 and tumor immune infiltration. Expression level of SLC9A1 gene in tumors was identified in GEPIA. The correlation between SLC9A1 and survival in various types of cancers was analyzed by the...
Chatterjee, Sujan Mishra, Snehasis Chowdhury, Kaustav Dutta Ghosh, Chandan Kumar Saha, Krishna Das
Published in
Life sciences
COVID-19 pandemic is still a major risk to human civilization. Besides the global immunization policy, more than five lac new cases are documented everyday. Some countries newly implement partial/complete nationwid lockdown to mitigate recurrent community spreading. To avoid the new modified stain of SARS-CoV-2 spreading, some countries imposed any...
Khalil, Ajlaa Sofya Mohd Giribabu, Nelli Yelumalai, Suseela Shahzad, Huma Kilari, Eswar Kumar Salleh, Naguib
Published in
Life sciences
Diabetes mellitus (DM) may lead to testicular-related infertility while Myristic acid (MA) is beneficial to lower hyperglycaemia. Thus, we hypothesized that MA could protect testes against hyperglycaemia-induced damage in DM. DM was induced in adult male rats by high-fat diet consumption for 12 weeks, accompanied by a single dose streptozotocin inj...
Wang, Ping Chen, Yan Zhang, La-Mei Yuan, Si-Qi Lu, Shen-Ao Zhang, Ying-Jian
Published in
Life sciences
Multidrug resistance gene (MDR1a) and P-glycoprotein (P-gp) play an important role in the development of ulcerative colitis (UC) and influence the therapeutic effect of glucocorticoids, which may lead to drug resistance mechanically. UC may be related to miR-145 to some extent, and the relationship still needs further exploration. In this study we ...
