Li, Meihe Wu, Xiaoling An, Peng Dang, Huimin Liu, Yanqiao Liu, Runxia
Published in
Life sciences
We aim to investigate whether there is activation of NLRP1 and autophagy in trophoblast oxidative stress model. Resveratrol was taken to clarify its role in oxidative damage of placental trophoblasts. H2O2 was added to HTR-8/SVneo cell for 3 h, then the ROS level and apoptosis panel was performed. The levels of IL-1β, caspase-1, NLRP1, LC3 and Becl...
Zou, Jing Liu, Kang-Cheng Wang, Wan-Peng Xu, Yi
Published in
Life sciences
The dysregulation of circular RNAs (circRNAs) has been implicated in the progression of diabetic retinopathy (DR). This study aims to explore the role and underlying mechanism of hsa_circ_0081108 (circCOL1A2) in DR. circCOL1A2, vascular endothelial growth factor (VEGF) and miR-29b expression levels in human retinal microvascular endothelial cells (...
Pandey, Abhjieet Nikam, Ajinkya Nitin Shreya, Ajjappla Basavaraj Mutalik, Sadhana P Gopalan, Divya Kulkarni, Sanjay Padya, Bharath Singh Fernandes, Gasper Mutalik, Srinivas Prassl, Ruth
...
Published in
Life sciences
The present pandemic of SARS-CoV-2 has been a tough task for the whole world to deal with. With the absence of specific drugs or vaccines against SARS-CoV-2, the situation is very difficult to control. Apart from the absence of specific therapies, the lack of knowledge about potential therapeutic targets and individual perception is adding to the c...
Amin, Fatma M Abdelaziz, Rania R Hamed, Mohamed F Nader, Manar A Shehatou, George S G
Published in
Life sciences
Vascular complications are a leading cause of morbidity and mortality among diabetic patients. This work aimed to investigate possible influences of dimethyl fumarate (DMF) on streptozotocin (STZ) diabetes-associated vascular complications in rats, exploring its potential to modulate ROS-TXNIP-NLRP3 inflammasome pathway. Two weeks after induction o...
Xie, Xiangrong Chen, Yan Liu, Jichun Zhang, Wenbo Zhang, Xuan Zha, Lintao Liu, Wenjie Ling, Yang Li, Shu Tang, Shengxing
...
Published in
Life sciences
Reactive oxygen species (ROS) caused by high glucose (HG) is involved in a lot of diseases including diabetes. However, the underlying mechanism of ROS induction by HG remains unclear. Emerging evidence has shown the 8-oxoguanine glycosylase (OGG1) is the main DNA glycosylase responsible for atherosclerosis, obesity, hepatic steatosis, and insulin ...
Zhou, Xianwu Cheng, Jiancheng Chen, Zerui Li, Huadong Chen, Shu Xu, Fei Fan, Ruixin Zhuang, Jian Sun, Tucheng
Published in
Life sciences
Angiotensin II (Ang II) induces aortic dissection (AD) via regulation of pathological changes in vascular smooth muscle cells (VSMCs). However, the molecular mechanisms involved are not fully understood. The aim of this study was to evaluate the potential role of the proto-oncogene non-receptor cellular Abelson tyrosine kinase (c-Abl) in Ang II-ind...
Fu, Qi Yu, Zhenhai
Published in
Life sciences
Phosphoglycerate kinase 1 (PGK1) is the first critical enzyme to produce ATP in the glycolytic pathway. PGK1 is not only a metabolic enzyme but also a protein kinase, which mediates the tumor growth, migration and invasion through phosphorylation some important substrates. Moreover, PGK1 is associated with poor treatment and prognosis of cancers. T...
Mai, Lijia Zhu, Xiao Huang, Fang He, Hongwen Fan, Wenguo
Published in
Life sciences
Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of ...
Maimaitijuma, Talatibaike Yu, Jia-Hong Ren, Ya-Li Yang, Xin Liu, Heng Meng, Zhi-Chao Wang, Rui Cui, Yun-Peng Wu, Hao Pan, Li-Ping
...
Published in
Life sciences
Osteoarthritis (OA) is the main cause of disability and joint replacement surgery in the elderly. As a crucial cell survival mechanism, autophagy has been reported to decrease in OA. PHF23 is a new autophagy inhibitor which was first reported by us previously. This study aimed to explore the anti-autophagic mechanism of PHF23 to make it a possible ...
Zhang, Yuan Qin, Lina Xie, Jieru Li, Juan Wang, Chong
Published in
Life sciences
Neuroinflammation and apoptosis play a crucial role in Parkinson's disease (PD) pathogenesis. Eupatilin is a lipophilic flavonoid isolated from Artemisia species and exerts anti-apoptotic and anti-inflammatory activities. In this study, we investigated the effects of Eupatilin on a mouse model of PD induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropy...
