Sportoletti, Paolo Sorcini, Daniele Guzman, Anna G Reyes, Jaime M Stella, Arianna Marra, Andrea Sartori, Sara Brunetti, Lorenzo Rossi, Roberta Papa, Beatrice Del
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Published in
Leukemia
Recurrent loss-of-function mutations of BCL6 co-repressor (BCOR) gene are found in about 4% of AML patients with normal karyotype and are associated with DNMT3a mutations and poor prognosis. Therefore, new anti-leukemia treatments and mouse models are needed for this combinatorial AML genotype. For this purpose, we first generated a Bcor-/- knockou...
Gritti, Giuseppe Raimondi, Federico Bottazzi, Barbara Ripamonti, Diego Riva, Ivano Landi, Francesco Alborghetti, Leonardo Frigeni, Marco Damiani, Marianna Micò, Caterina
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Leukemia
Kucia, Magdalena Ratajczak, Janina Bujko, Kamila Adamiak, Mateusz Ciechanowicz, Andrzej Chumak, Vira Brzezniakiewicz-Janus, Katarzyna Ratajczak, Mariusz Z.
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Leukemia
Gourvest, Morgane De Clara, Etienne Wu, Hsin-Chieh Touriol, Christian Meggetto, Fabienne De Thé, Hugues Pyronnet, Stéphane Brousset, Pierre Bousquet, Marina
Published in
Leukemia
The most frequent genetic alteration in acute myeloid leukemia (AML) is the mutation of nucleophosmin 1 (NPM1). Yet, its downstream oncogenic routes are not fully understood. Here, we report the identification of one l ong noncoding RNA (lncRNA) o verexpressed in N PM1-mutated A ML patients (named LONA) whose intracellular localization inversely re...
Ljungman, Per de la Camara, Rafael Mikulska, Malgorzata Tridello, Gloria Aguado, Beatriz Zahrani, Mohsen Al Apperley, Jane Berceanu, Ana Bofarull, Rodrigo Martino Calbacho, Maria
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Leukemia
This study reports on 382 COVID-19 patients having undergone allogeneic ( n = 236) or autologous ( n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0–80.3) for allo...
Dinnessen, Manette A W van der Poel, Marjolein W M Tonino, Sanne H Visser, Otto Blijlevens, Nicole M A de Jong, Daphne Lam, King H Kersten, Marie José Lugtenburg, Pieternella J Dinmohamed, Avinash G
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Leukemia
We assessed stage-specific trends in primary therapy and relative survival among adult follicular lymphoma (FL) patients diagnosed in the Netherlands between 1989-2016 (N = 12,372; median age, 62 years; and 21% stage I disease). Patients were stratified by disease stage and subsequently categorized into four calendar periods (1989-1995, 1996-2002, ...
Bewersdorf, Jan Philipp Giri, Smith Wang, Rong Podoltsev, Nikolai Williams, Robert T Tallman, Martin S Rampal, Raajit K Zeidan, Amer M Stahl, Maximilian
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Leukemia
Data on the efficacy and safety of interferon (IFN)-α for the treatment of essential thrombocythemia (ET) and polycythemia vera (PV) are inconsistent. We conducted a systematic review and meta-analysis and searched MEDLINE and EMBASE via Ovid, Scopus, COCHRANE registry of clinical trials, and Web of Science from inception through 03/2019 for studie...
Zhang, Cheng Wang, Xiao-Qi Zhang, Rong-Li Liu, Fang Wang, Yi Yan, Zhi-Ling Song, Yong-Ping Yang, Ting Li, Ping Wang, Zhen
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Leukemia
Safety and efficacy of allogeneic anti-CD19 chimeric antigen receptor T cells (CAR-T cells) in persons with CD19-positive B-cell acute lymphoblastic leukemia (B-ALL) relapsing after an allotransplant remain unclear. Forty-three subjects with B-ALL relapsing post allotransplant received CAR-T cells were analyzed. 34 (79%; 95% confidence interval [CI...
Martínez-Cuadrón, David Serrano, Josefina Gil, Cristina Tormo, Mar Martínez-Sánchez, Pilar Pérez-Simón, José A García-Boyero, Raimundo Rodríguez-Medina, Carlos López-Pavía, María Benavente, Celina
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Leukemia
There are no studies analyzing how therapeutic changes impact on outcomes of older AML patients. This study analyzes patient´s and disease characteristics, treatment patterns, and outcomes of 3637 AML patients aged ≥60 years reported to the PETHEMA registry. Study periods were 1999-2006 (before hypomethylating agents-HMAs availability) vs 2007-2013...
Gu, Chunyan Lu, Ting Wang, Wang Shao, Miaomiao Wei, Rongfang Guo, Mengjie Li, Rui Qiao, Li Hu, Ye Zhan, Fenghuang
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Published in
Leukemia
