Cohen, Ezra E W Soulières, Denis Le Tourneau, Christophe Dinis, José Licitra, Lisa Ahn, Myung-Ju Soria, Ainara Machiels, Jean-Pascal Mach, Nicolas Mehra, Ranee
...
Published in
Lancet (London, England)
There are few effective treatment options for patients with recurrent or metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour activity and manageable toxicity in early-phase trials. We aimed to compare the efficacy and safety of pembrolizumab versus standard-of-care therapy for the treatment of head-and-neck squamous ce...
Baraliakos, Xenofon Braun, Juergen
Published in
Lancet (London, England)
van der Heijde, Désirée Cheng-Chung Wei, James Dougados, Maxime Mease, Philip Deodhar, Atul Maksymowych, Walter P Van den Bosch, Filip Sieper, Joachim Tomita, Tetsuya Landewé, Robert
...
Published in
Lancet (London, England)
Biological disease-modifying anti-rheumatic drugs (bDMARDs) are recommended for radiographic axial spondyloarthritis, otherwise known as ankylosing spondylitis, when conventional therapies are not effective. We report efficacy and safety data on ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A (IL-17A), in pa...
Mease, Philip Coates, Laura C Helliwell, Philip S Stanislavchuk, Mykola Rychlewska-Hanczewska, Anna Dudek, Anna Abi-Saab, Walid Tasset, Chantal Meuleners, Luc Harrison, Pille
...
Published in
Lancet (London, England)
The Janus kinase 1 (JAK1) pathway has been implicated in the pathogenesis of psoriatic arthritis. We aimed to investigate the efficacy and safety of filgotinib, a selective JAK1 inhibitor, for the treatment of psoriatic arthritis. The EQUATOR trial was a randomised, double-blind, placebo-controlled phase 2 trial that enrolled adults from 25 sites i...
Boeri, Luca Sharma, Vidit Karnes, R Jeffrey
Published in
Lancet (London, England)
van der Heijde, Désirée Baraliakos, Xenofon Gensler, Lianne S Maksymowych, Walter P Tseluyko, Vira Nadashkevich, Oleg Abi-Saab, Walid Tasset, Chantal Meuleners, Luc Besuyen, Robin
...
Published in
Lancet (London, England)
At present, biological disease-modifying anti-rheumatic drugs (DMARDs) are the only treatment recommended for patients with ankylosing spondylitis who have not responded to first-line treatment with non-steroidal anti-inflammatory drugs (NSAIDs). The TORTUGA trial investigated the efficacy and safety of filgotinib, an oral selective Janus kinase 1 ...
Parker, Christopher C James, Nicholas D Brawley, Christopher D Clarke, Noel W Hoyle, Alex P Ali, Adnan Ritchie, Alastair W S Attard, Gerhardt Chowdhury, Simon Cross, William
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Published in
Lancet (London, England)
Based on previous findings, we hypothesised that radiotherapy to the prostate would improve overall survival in men with metastatic prostate cancer, and that the benefit would be greatest in patients with a low metastatic burden. We aimed to compare standard of care for metastatic prostate cancer, with and without radiotherapy. We did a randomised ...
McInnes, Iain B Siebert, Stefan
Published in
Lancet (London, England)
Malhi, Gin S Mann, J John
Published in
Lancet (London, England)
Major depression is a common illness that severely limits psychosocial functioning and diminishes quality of life. In 2008, WHO ranked major depression as the third cause of burden of disease worldwide and projected that the disease will rank first by 2030.1 In practice, its detection, diagnosis, and management often pose challenges for clinicians ...
Devi, Sharmila
Published in
Lancet (London, England)
