Johansson, S. Andreas Dulermo, Thierry Jann, Cosimo Smith, Justin D. Pryszlak, Anna Pignede, Georges Schraivogel, Daniel Colavizza, Didier Desfougères, Thomas Rave, Christophe
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Published in
Lab on a chip
Key to our ability to increase recombinant protein production through secretion is a better understanding of the pathways that interact to translate, process and export mature proteins to the surrounding environment, including the supporting cellular machinery that supplies necessary energy and building blocks. By combining droplet microfluidic scr...
Zhang, Pengfei Xu, Linfeng Chen, Huawei Abate, Adam R
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Lab on a chip
Delivery of double emulsions in air is crucial for their applications in mass spectrometry, bioanalytics, and material synthesis. However, while methods have been developed to generate double emulsions in air, controlled printing of double emulsion droplets has not been achieved yet. In this paper, we present an approach for in-air printing of doub...
He, Xinyu Xu, Junyan Wang, Xiaoli Ge, Chuang Li, Shunbo Wang, Li Xu, Yi
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Lab on a chip
In this paper, a multifunctional microfluidic chip integrated with a centrifugal separation zone, aqueous two-phase system (ATPS) mixing zone and enrichment detection zone was proposed and fabricated. An automatic and efficient separation and quantitative analysis method for vascular endothelial growth factor 165 (VEGF165) in whole blood samples wa...
De Masi, Alessandra Scognamiglio, Pasqualina Liana Battista, Edmondo Netti, Paolo Antonio Causa, Filippo
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Lab on a chip
Novel microparticles have generated growing interest in diagnostics for potential sensitivity and specificity in biomolecule detection and for the possibility to be integrated in a micro-system array as a lab-on-chip. Indeed, bead-based technologies integrated in microfluidics could speed up incubation steps, reduce reagent consumption and improve ...
Kim, Seo Yeon Ha, Seong Min Kim, Dong-Uk Park, Junhyun Park, Sunyoung Hyun, Kyung-A Jung, Hyo-Il
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Lab on a chip
Extracellular vesicles (EVs) are nanometer-sized particles naturally secreted by cells for intercellular communication that encapsulate bioactive cargo, such as proteins and RNA, with a lipid bilayer. Tumor cell-derived EVs (tdEVs) are particularly promising biomarkers for cancer research because their contents reflect the cell of origin. In most s...
Cognetti, John S Moen, Maya T Brewer, Matthew G Bryan, Michael R Tice, Joshua D McGrath, James L Miller, Benjamin L
Published in
Lab on a chip
Tissue chip (TC) devices, also known as microphysiological systems (MPS) or organ chips (OCs or OoCs), seek to mimic human physiology on a small scale. They are intended to improve upon animal models in terms of reproducibility and human relevance, at a lower monetary and ethical cost. Virtually all TC systems are analyzed at an endpoint, leading t...
Bachal, Ketaki Yadav, Shital Gandhi, Prasanna Majumder, Abhijit
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Lab on a chip
Drug testing is a vital step in the identification of the potential efficacy of any new/existing drug and/or combinations of drugs. The conventional methods of testing the efficacy of new drugs using multiwell plates are time consuming and prone to evaporation loss and manual error. Microfluidic devices with automated generation of concentration gr...
Doi, Kotaro Kimura, Hiroshi Kim, Soo Hyeon Kaneda, Shohei Wada, Takehiko Tanaka, Tetsuhiro Shimizu, Akira Sano, Takanori Chikamori, Masamichi Shinohara, Marie
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Lab on a chip
Podocytes, localized in the glomerulus, are a prognostic factor of proteinuria in kidney disease and are exposed to distinct physiological stimuli from basal to apical filtration flow. Research studies on drug discovery and disease modeling for glomerulopathy have developed a glomerulus-on-a-chip and studied podocyte mechanobiology to realize alter...
Shi, Weihua Bell, Sara Iyer, Hrishikesh Brenden, Christopher Kenji Zhang, Yan Kim, Sungho Park, Insu Bashir, Rashid Sweedler, Jonathan Vlasov, Yurii
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Lab on a chip
A silicon single-chip microfluidics system that integrates microscale fluidic channels, an analyte segmentation device, and a nozzle for electrohydrodynamic-assisted printing is designed for hyphenation with MALDI mass spectrometry (MS) imaging. A miniaturized T-junction segments analytes into monodisperse picoliter oil-isolated compartments. The p...
Yang, Ning Li, Taiwei Dong, Sizhe Zhang, Suliang Jia, Yanwei Mao, Hanping Zhang, Zhen Zhang, Fu Pan, Xiaoqing Zhang, Xiaodong
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Lab on a chip
Correction for 'Detection of airborne pathogens with single photon counting and a real-time spectrometer on microfluidics' by Ning Yang et al., Lab Chip, 2022, https://doi.org/10.1039/D2LC00934J.