Binsley, Jacob L. Martin, Elizabeth L. Myers, Thomas O. Pagliara, Stefano Ogrin, Feodor Y.
Published in
Lab on a Chip
We show how an asymmetric elasto-magnetic system provides a novel integrated pumping solution for lab-on-a-chip and point of care devices. This monolithic pumping solution, inspired by Purcell's 3-link swimmer, is integrated within a simple microfluidic device, bypassing the requirement of external connections. We experimentally prove that this sys...
Schurdak, Mark Vernetti, Lawrence Bergenthal, Luke Wolter, Quinn K. Shun, Tong Ying Karcher, Sandra Taylor, D. Lansing Gough, Albert
Published in
Lab on a Chip
To accelerate the development and application of Microphysiological Systems (MPS) in biomedical research and drug discovery/development, a centralized resource is required to provide the detailed design, application, and performance data that enables industry and research scientists to select, optimize, and/or develop new MPS solutions, as well as ...
Özkale, Berna Parreira, Raquel Bekdemir, Ahmet Pancaldi, Lucio Özelçi, Ece Amadio, Claire Kaynak, Murat Stellacci, Francesco Mooney, David J Sakar, Mahmut Selman
...
Published in
Lab on a chip
We present a methodology for building biologically inspired, soft microelectromechanical systems (MEMS) devices. Our strategy combines several advanced techniques including programmable colloidal self-assembly, light-harvesting with plasmonic nanotransducers, and in situ polymerization of compliant hydrogel mechanisms. We synthesize optomechanical ...
Al Nahas, K Cama, J Schaich, M Hammond, K Deshpande, S Dekker, C Ryadnov, M G Keyser, U F
Published in
Lab on a chip
The spread of bacterial resistance against conventional antibiotics generates a great need for the discovery of novel antimicrobials. Polypeptide antibiotics constitute a promising class of antimicrobial agents that favour attack on bacterial membranes. However, efficient measurement platforms for evaluating their mechanisms of action in a systemat...
Bao, Peng Paterson, Daniel A. Harrison, Patrick L. Miller, Keith Peyman, Sally Jones, J. Cliff Sandoe, Jonathan Evans, Stephen D. Bushby, Richard J. Gleeson, Helen F.
...
Published in
Lab on a Chip
We describe a novel biosensor based on phospholipid-coated nematic liquid crystal (LC) droplets and demonstrate the detection of Smp43, a model antimicrobial peptide (AMP) from the venom of North African scorpion Scorpio maurus palmatus . Mono-disperse lipid-coated LC droplets of diameter 16.7 ± 0.2 μm were generated using PDMS microfluidic devices...
Nikhil Raj Breedveld, V. Hess, D. W.
Published in
Lab on a Chip
A fully enclosed paper microfluidic device has been fabricated using pentafluoroethane (PFE) plasma deposition followed by O2 plasma etching. Structures with one and two non-interacting, fully enclosed hydrophilic channels were generated in a single paper sheet using metal masks. Furthermore, by performing an additional O2 plasma step with a second...
Dong, Zhengya Fernandez Rivas, David Kuhn, Simon
Published in
Lab on a chip
The handling of solids in microreactors represents a challenging task. In this paper, we present an acoustophoretic microreactor developed to manage particles in flow and to control the material synthesis process. The reactor was designed as a layered resonator with an actuation frequency of 1.21 MHz, in which a standing acoustic wave is generated ...
van den Berg, Albert Mummery, Christine L Passier, Robert van der Meer, Andries D
Published in
Lab on a chip
Organs-on-chips are microfluidic systems with controlled, dynamic microenvironments in which cultured cells exhibit functions that emulate organ-level physiology. They can in principle be 'personalised' to reflect individual physiology, for example by including blood samples, primary human tissue, and cells derived from induced pluripotent stem cel...
Bordonali, Lorenzo Nordin, Nurdiana Fuhrer, Erwin MacKinnon, Neil Korvink, Jan G.
Published in
Lab on a Chip
Complex mixtures, commonly encountered in metabolomics and food analytics, are now routinely measured by nuclear magnetic resonance (NMR) spectroscopy. Since many samples must be measured, one-dimensional proton (1D 1H) spectroscopy is the experiment of choice. A common challenge in complex mixture 1H NMR spectroscopy is spectral crowding, which li...
Rackus, Darius G de Campos, Richard P S Chan, Calvin Karcz, Maria M Seale, Brendon Narahari, Tanya Dixon, Christopher Chamberlain, M Dean Wheeler, Aaron R
Published in
Lab on a chip
Microfluidic platforms are an attractive option for incorporating complex fluid handling into low-cost and rapid diagnostic tests. A persistent challenge for microfluidics, however, is the mismatch in the "world-to-chip" interface - it is challenging to detect analytes present at low concentrations in systems that can only handle small volumes of s...
