Josephson, Michelle A Becker, Yolanda Budde, Klemens Kasiske, Bertram L Kiberd, Bryce A Loupy, Alexandre Małyszko, Jolanta Mannon, Roslyn B Tönshoff, Burkhard Cheung, Michael
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Published in
Kidney international
In March 2022, Kidney Disease: Improving Global Outcomes (KDIGO) held a virtual Controversies Conference to address the important but rarely examined phase during which the kidney transplant is failing or has failed. In addition to discussing the definition of a failing allograft, 4 broad areas were considered in the context of a declining function...
Fogo, Agnes B
Published in
Kidney international
Mimura, Imari Nangaku, Masaomi
Published in
Kidney international
Eckardt, Kai-Uwe Delgado, Cynthia Heerspink, Hiddo J L Pecoits-Filho, Roberto Ricardo, Ana C Stengel, Bénédicte Tonelli, Marcello Cheung, Michael Jadoul, Michel Winkelmayer, Wolfgang C
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Published in
Kidney international
Chronic kidney disease (CKD) affects over 850 million people globally, and the need to prevent its development and progression is urgent. During the past decade, new perspectives have arisen related to the quality and precision of care for CKD, owing to the development of new tools and interventions for CKD diagnosis and management. New biomarkers,...
Lizotte, Farah Rousseau, Marina Denhez, Benoit Lévesque, Dominique Guay, Andréanne Liu, HongBo Moreau, Julie Higgins, Sarah Sabbagh, Robert Susztak, Katalin
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Published in
Kidney international
Both clinical and experimental data suggest that podocyte injury is involved in the onset and progression of diabetic kidney disease (DKD). Although the mechanisms underlying the development of podocyte loss are not completely understood, critical structural proteins such as podocin play a major role in podocyte survival and function. We have repor...
Dobrijevic, Ellen van Zwieten, Anita Kiryluk, Krzsztof Grant, Andrew J Wong, Germaine Teixeira-Pinto, Armando
Published in
Kidney international
Confounding is major limitation of observational studies. Mendelian randomization (MR) is a powerful study design that uses genetic variants as instrumental variables to enable examination of the causal effect of an exposure on an outcome in observational data. With the emergence of large-scale genome wide association studies in nephrology over the...
Clark, Amanda J Saade, Marie Christelle Vemireddy, Vamsidhara Vu, Kyle Q Flores, Brenda Mendoza Etzrodt, Valerie Ciampa, Erin J Huang, Huihui Takakura, Ayumi Zandi-Nejad, Kambiz
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Published in
Kidney international
Nicotinamide adenine dinucleotide (NAD+) levels decline in experimental models of acute kidney injury (AKI). Attenuated enzymatic conversion of tryptophan to NAD+ in tubular epithelium may contribute to adverse cellular and physiological outcomes. Mechanisms underlying defense of tryptophan-dependent NAD+ production are incompletely understood. Her...
Bhandari, Sunil Mehta, Samir Khawaja, Arif Cleland, John G F Ives, Natalie Cockwell, Paul
Published in
Kidney international
In the STOP-ACEi trial, the outcome was similar whether or not renin-angiotensin system inhibitors (RASi) were discontinued. We now investigate whether the effect of withdrawing angiotensin converting enzyme inhibitors (ACEi) or angiotensin-receptor blockers (ARBs) differed. In this open label trial patients with estimated glomerular filtration rat...
Keller, Svenja Chen, Zhiyong Gaponova, Anna Korzinkin, Mikhail Berquez, Marine Luciani, Alessandro
Published in
Kidney international
The efficient reabsorption of essential nutrients by epithelial cells in the proximal tubule of the kidney is crucial for maintaining homeostasis. This process heavily relies on a complex ecosystem of vesicular trafficking pathways. At the center of this network, the lysosome plays a pivotal role in processing incoming molecules, sensing nutrient a...
Unnersjö-Jess, David Ramdedovic, Amer Butt, Linus Plagmann, Ingo Höhne, Martin Hackl, Agnes Brismar, Hjalmar Blom, Hans Schermer, Bernhard Benzing, Thomas
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Published in
Kidney international
Mammalian kidneys filter enormous volumes of water and small solutes, a filtration driven by the hydrostatic pressure in glomerular capillaries, which is considerably higher than in most other tissues. Interdigitating cellular processes of podocytes form the slits for fluid filtration connected by the membrane-like slit diaphragm cell junction cont...
