Sise, Meghan E Chute, Donald F Oppong, Yaa Davis, Maya I Long, Joshua D Silva, Sakuni T Rusibamayila, Nifasha Jean-Francois, Deborah Raji, Syeda Zhao, Sophia
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Published in
Kidney international
Hepatitis C virus (HCV) infection is common and can accelerate chronic kidney disease (CKD) progression. Direct-acting antiviral (DAA) therapies against hepatitis C have consistently shown rates of sustained viral remission. However, the effect on kidney function is unknown. In a retrospective observational cohort study of HCV-infected patients rec...
Zhang, Dan Gava, Agata L Van Krieken, Richard Mehta, Neel Li, Renzhong Gao, Bo Desjardins, Eric M Steinberg, Gregory R Hawke, Thomas Krepinsky, Joan C
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Published in
Kidney international
Glomerular matrix protein accumulation, mediated largely by mesangial cells, is central to the pathogenesis of diabetic kidney disease. Our previous studies showed that the membrane microdomains caveolae and their marker protein caveolin-1 regulate matrix protein synthesis in mesangial cells in response to diabetogenic stimuli, and that caveolin-1 ...
Miao, Naijun Yin, Fan Xie, Hongyan Wang, Yanzhe Xu, Yiang Shen, Yang Xu, Dan Yin, Jianyong Wang, Bao Zhou, Zhuanli
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Published in
Kidney international
Inflammation and tubular cell death are the hallmarks of acute kidney injury. However, the precise mechanism underlying these effects has not been fully elucidated. Here we tested whether caspase-11, an inflammatory member of the caspase family, was increased in cisplatin or ischemia-reperfusion-induced acute kidney injury. Caspase-11 knockout mice...
Peerapornratana, Sadudee Manrique-Caballero, Carlos L Gómez, Hernando Kellum, John A
Published in
Kidney international
Sepsis-associated acute kidney injury (S-AKI) is a frequent complication of the critically ill patient and is associated with unacceptable morbidity and mortality. Prevention of S-AKI is difficult because by the time patients seek medical attention, most have already developed acute kidney injury. Thus, early recognition is crucial to provide suppo...
Edmonston, Daniel L Wyatt, Christina M Al-Khatib, Sana M
Published in
Kidney international
Gan, Poh-Yi Chan, Amy Ooi, Joshua D Dick, Jonathan Nagai, Kei O'Sullivan, Kim M Oudin, Virginie Shim, Raymond Kitching, A Richard Holdsworth, Stephen R
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Published in
Kidney international
Anti-myeloperoxidase nephritogenic autoimmunity induces severe glomerulonephritis. To assess the therapeutic potential of monoclonal antibodies targeting T helper (Th) subset differentiation determining cytokines, we studied a murine model of anti-myeloperoxidase glomerulonephritis. The temporal participation of T helper subsets was determined by q...
Yoshimura, Yasuhiro Nishinakamura, Ryuichi
Published in
Kidney international
The glomerular podocyte is one of the major targets of kidney research. Recent establishment of kidney organoids from pluripotent stem cells has enabled the detailed analysis of human podocytes in both development and disease. The podocytes in organoids express slit diaphragm-related genes and proteins and exhibit characteristic morphology, especia...
McCallum, Wendy Tighiouart, Hocine Ku, Elaine Salem, Deeb Sarnak, Mark J
Published in
Kidney international
Angiotensin-converting enzyme inhibitors are beneficial in heart failure with reduced ejection fraction but are associated with acute declines in estimated glomerular filtration rate (eGFR). Prior studies evaluating thresholds of eGFR decline while using angiotensin-converting enzyme inhibitors in heart failure with reduced ejection have not taken ...
Alencar de Pinho, Natalia Levin, Adeera Fukagawa, Masafumi Hoy, Wendy E Pecoits-Filho, Roberto Reichel, Helmut Robinson, Bruce Kitiyakara, Chagriya Wang, Jinwei Eckardt, Kai-Uwe
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Published in
Kidney international
Although blood pressure control is a major goal in chronic kidney disease, no worldwide overview of either its achievement or antihypertensive prescriptions is currently available. To evaluate this we compared crude prevalence of uncontrolled blood pressure among 17 cohort studies, including 34 602 individuals with estimated glomerular filtration r...
Ebefors, Kerstin Wiener, Robert J Yu, Liping Azeloglu, Evren U Yi, Zhengzi Jia, Fu Zhang, Weijia Baron, Margaret H He, John C Haraldsson, Börje
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Published in
Kidney international
Emerging evidence of crosstalk between glomerular cells in pathological settings provides opportunities for novel therapeutic discovery. Here we investigated underlying mechanisms of early events leading to filtration barrier defects of podocyte and glomerular endothelial cell crosstalk in the mouse models of primary podocytopathy (podocyte specifi...
