Schroder, Paul M Schmitz, Robin Fitch, Zachary W Ezekian, Brian Yoon, Janghoon Choi, Ashley Y Manook, Miriam Barbas, Andrew Leopardi, Frank Song, Mingqing
...
Published in
Kidney international
Sensitized patients are difficult to transplant due to pre-formed anti-donor immunity. We have previously reported successful desensitization using carfilzomib and belatacept in a non-human primate (NHP) model. Here we evaluated selective blockade of the co-stimulatory signal (CD28-B7) with Lulizumab, which preserves the co-inhibitory signal (CTLA4...
Bardin, Thomas Nguyen, Quang D Tran, Khoy M Le, Nghia H Do, Minh D Richette, Pascal Letavernier, Emmanuel Correas, Jean-Michel Resche-Rigon, Mathieu
Published in
Kidney international
We have previously shown that ultrasonography can detect hyperechogenic crystal deposits in the kidney medulla of patients with gout. In this cross-sectional study we investigated the frequency and clinical correlates of hyperechogenic kidney medulla in 502 consecutive primary consultants for gout (ACR/EULAR criteria) at the Vien Gut medical center...
Hirsch, Jamie S Ng, Jia H Ross, Daniel W Sharma, Purva Shah, Hitesh H Barnett, Richard L Hazzan, Azzour D Fishbane, Steven Jhaveri, Kenar D
Published in
Kidney international
The rate of acute kidney injury (AKI) associated with patients hospitalized with Covid-19, and associated outcomes are not well understood. This study describes the presentation, risk factors and outcomes of AKI in patients hospitalized with Covid-19. We reviewed the health records for all patients hospitalized with Covid-19 between March 1, and Ap...
Su, Hua Yang, Ming Wan, Cheng Yi, Li-Xia Tang, Fang Zhu, Hong-Yan Yi, Fan Yang, Hai-Chun Fogo, Agnes B Nie, Xiu
...
Published in
Kidney international
Although the respiratory and immune systems are the major targets of Coronavirus Disease 2019 (COVID-19), acute kidney injury and proteinuria have also been observed. Currently, detailed pathologic examination of kidney damage in critically ill patients with COVID-19 has been lacking. To help define this we analyzed kidney abnormalities in 26 autop...
Baues, Maike Klinkhammer, Barbara M Ehling, Josef Gremse, Felix van Zandvoort, Marc A M J Reutelingsperger, Chris P M Daniel, Christoph Amann, Kerstin Bábíčková, Janka Kiessling, Fabian
...
Published in
Kidney international
Pathological deposition of collagen is a hallmark of kidney fibrosis. To illustrate this process we employed multimodal optical imaging to visualize and quantify collagen deposition in murine models of kidney fibrosis (ischemia-reperfusion or unilateral ureteral obstruction) using the collagen-binding adhesion protein CNA35. For in vivo imaging, we...
Terker, Andrew de Caestecker, Mark P.
Published in
Kidney international
Sise, Meghan E Chute, Donald F Oppong, Yaa Davis, Maya I Long, Joshua D Silva, Sakuni T Rusibamayila, Nifasha Jean-Francois, Deborah Raji, Syeda Zhao, Sophia
...
Published in
Kidney international
Hepatitis C virus (HCV) infection is common and can accelerate chronic kidney disease (CKD) progression. Direct-acting antiviral (DAA) therapies against hepatitis C have consistently shown rates of sustained viral remission. However, the effect on kidney function is unknown. In a retrospective observational cohort study of HCV-infected patients rec...
Verma, Nirmal Liu, Miao Ly, Han Loria, Analia Campbell, Kenneth S Bush, Heather Kern, Philip A Jose, Pedro A Taegtmeyer, Heinrich Bers, Donald M
...
Published in
Kidney international
In the setting of type-2 diabetes, there are declines of structural stability and functionality of blood capillaries and red blood cells (RBCs), increasing the risk for microcirculatory disturbances. Correcting hyperglycemia is not entirely effective at reestablishing normal cellular metabolism and function. Therefore, identification of pathologica...
Lankadeva, Yugeesh R Ma, Shuai Iguchi, Naoya Evans, Roger G Hood, Sally G Farmer, David G S Bailey, Simon R Bellomo, Rinaldo May, Clive N
Published in
Kidney international
Norepinephrine exacerbates renal medullary hypoxia in experimental septic acute kidney injury. Here we examined whether dexmedetomidine, an α2-adrenergic agonist, can restore vasopressor responsiveness, decrease the requirement for norepinephrine and attenuate medullary hypoxia in ovine gram-negative sepsis. Sheep were instrumented with pulmonary a...
Araújo, Maria Júlia Correia Lima Nepomuc... Bacelar Marques, Igor Denizarde Graciolli, Fabiana Giorgetti Fukuhara, Luzia Machado Dos Reis, Luciene Custódio, Melani Jorgetti, Vanda Elias, Rosilene Mota David-Neto, Elias Moysés, Rosa M A
...
Published in
Kidney international
In an attempt to clarify the mechanisms of post-transplant bone disease we investigated the bone content and gene expression of several bone-related proteins. After a successful kidney transplant, the content of sclerostin in bone biopsies was found to be increased as measured by immunohistochemistry, multiplex assay, and gene expression despite a ...
