Lanoix, Jean-Philippe Mammeri, Youcef Schmit, Jean-Luc Lefranc, Michel
Published in
Journal of the Royal Society Interface
The global pandemic of coronavirus disease 2019 (COVID-19) has challenged healthcare systems worldwide. Lockdown, social distancing, and screening are thought to be the best means of stopping the virus from spreading and thus of preventing hospital capacity from being overloaded. However, it has also been suggested that effective outpatient treatme...
Southall, Emma Brett, Tobias S. Tildesley, Michael J. Dyson, Louise
Published in
Journal of the Royal Society Interface
Early warning signals (EWSs) are a group of statistical time-series signals which could be used to anticipate a critical transition before it is reached. EWSs are model-independent methods that have grown in popularity to support evidence of disease emergence and disease elimination. Theoretical work has demonstrated their capability of detecting d...
Johnston, S. T. Painter, K. J.
Published in
Journal of the Royal Society Interface
Collective migration occurs throughout the animal kingdom, and demands both the interpretation of navigational cues and the perception of other individuals within the group. Navigational cues orient individuals towards a destination, while it has been demonstrated that communication between individuals enhances navigation through a reduction in ori...
Harvey, Andrew Kattuman, Paul
Published in
Journal of the Royal Society Interface
The time-dependent reproduction number, R t , is a key metric used by epidemiologists to assess the current state of an outbreak of an infectious disease. This quantity is usually estimated using time-series observations on new infections combined with assumptions about the distribution of the serial interval of transmissions. Bayesian methods are ...
Burton, Joshua Manning, Cerys S. Rattray, Magnus Papalopulu, Nancy Kursawe, Jochen
Published in
Journal of the Royal Society Interface
Gene expression dynamics, such as stochastic oscillations and aperiodic fluctuations, have been associated with cell fate changes in multiple contexts, including development and cancer. Single cell live imaging of protein expression with endogenous reporters is widely used to observe such gene expression dynamics. However, the experimental investig...
Carr, Michael J. Simpson, Matthew J. Drovandi, Christopher
Published in
Journal of the Royal Society Interface
We develop a parameter estimation method based on approximate Bayesian computation (ABC) for a stochastic cell invasion model using fluorescent cell cycle labelling with proliferation, migration and crowding effects. Previously, inference has been performed on a deterministic version of the model fitted to cell density data, and not all parameters ...
Lim, Jue Tao Dickens, Borame Sue Tan, Ken Wei Koo, Joel Ruihan Seah, Annabel Ho, Soon Hoe Ong, Janet Rajarethinam, Jayanthi Soh, Stacy Cook, Alex R.
...
Published in
Journal of the Royal Society Interface
Over 105 million dengue infections are estimated to occur annually. Understanding the disease dynamics of dengue is often difficult due to multiple strains circulating within a population. Interactions between dengue serotype dynamics may result in complex cross-immunity dynamics at the population level and create difficulties in terms of formulati...
Bergantin, Lucia Harbaoui, Nesrine Raharijaona, Thibaut Ruffier, Franck
Published in
Journal of the Royal Society Interface
Honeybees foraging and recruiting nest-mates by performing the waggle dance need to be able to gauge the flight distance to the food source regardless of the wind and terrain conditions. Previous authors have hypothesized that the foragers’ visual odometer mathematically integrates the angular velocity of the ground image sweeping backward across t...
Holzapfel, Gerhard A. Linka, Kevin Sherifova, Selda Cyron, Christian J.
Published in
Journal of the Royal Society Interface
The constitutive modelling of soft biological tissues has rapidly gained attention over the last 20 years. Current constitutive models can describe the mechanical properties of arterial tissue. Predicting these properties from microstructural information, however, remains an elusive goal. To address this challenge, we are introducing a novel hybrid...
Yeung, Enoch Kim, Jongmin Yuan, Ye Gonçalves, Jorge Murray, Richard M.
Published in
Journal of the Royal Society Interface
Synthetic gene networks are frequently conceptualized and visualized as static graphs. This view of biological programming stands in stark contrast to the transient nature of biomolecular interaction, which is frequently enacted by labile molecules that are often unmeasured. Thus, the network topology and dynamics of synthetic gene networks can be ...
