Poyraz, Onur Sater, Mohamad R A Miller, Loren G McKinnell, James A Huang, Susan S Grad, Yonatan H Marttinen, Pekka
Published in
Journal of the Royal Society, Interface
Methicillin-resistant Staphylococcus aureus (MRSA) can colonize multiple body sites, and carriage is a risk factor for infection. Successful decolonization protocols reduce disease incidence; however, multiple protocols exist, comprising diverse therapies targeting multiple body sites, and the optimal protocol is unclear. Standard methods cannot in...
Favero, Martina Scalia Tomba, Gianpaolo Britton, Tom
Published in
Journal of the Royal Society, Interface
We present a stochastic epidemic model to study the effect of various preventive measures, such as uniform reduction of contacts and transmission, vaccination, isolation, screening and contact tracing, on a disease outbreak in a homogeneously mixing community. The model is based on an infectivity process, which we define through stochastic contact ...
Zhang, Yafei Wang, Lin Zhu, Jonathan J. H. Wang, Xiaofan
The ongoing coronavirus disease 2019 (COVID-19) pandemic has wreaked havoc worldwide with millions of lives claimed, human travel restricted and economic development halted. Leveraging city-level mobility and case data, our analysis shows that the spatial dissemination of COVID-19 can be well explained by a local diffusion process in the mobility n...
Li, Meng Seinsche, Clara Jansson, Samuel Hernandez, Julio Rota, Jadranka Warrant, Eric Brydegaard, Mikkel
Published in
Journal of the Royal Society Interface
There are hundreds of thousands of moth species with crucial ecological roles that are often obscured by their nocturnal lifestyles. The pigmentation and appearance of moths are dominated by cryptic diffuse shades of brown. In this study, 82 specimens representing 26 moth species were analysed using infrared polarimetric hyperspectral imaging in th...
Contreras, Diego Andrés Colosi, Elisabetta Bassignana, Giulia Colizza, Vittoria Barrat, Alain
Published in
Journal of the Royal Society Interface
Computational models offer a unique setting to test strategies to mitigate the spread of infectious diseases, providing useful insights to applied public health. To be actionable, models need to be informed by data, which can be available at different levels of detail. While high-resolution data describing contacts between individuals are increasin...
Zhao, Gang Straub, Rainer H. Meyer-Hermann, Michael
Published in
Journal of the Royal Society Interface
Background: Different parts of an organism like the gut, endocrine, nervous and immune systems constantly exchange information. Understanding the pathogenesis of various systemic chronic diseases increasingly relies on understanding how these subsystems orchestrate their activities. Methods: We started from the working hypothesis that energy is a f...
Wolff-Vorbeck, Steve Speck, Olga Langer, Max Speck, Thomas Dondl, Patrick W.
Published in
Journal of the Royal Society Interface
During the evolution of land plants many body plans have been developed. Differences in the cross-sectional geometry and tissue pattern of plant axes influence their flexural rigidity, torsional rigidity and the ratio of both of these rigidities, the so-called twist-to-bend ratio. For comparison, we have designed artificial cross-sections with vari...
Lemanis, Robert Tadayon, Kian Reich, Elke Joshi, Gargi Johannes Best, Richard Stevens, Kevin Zlotnikov, Igor
Published in
Journal of the Royal Society, Interface
The ability of evolution to shape organic form involves the interactions of multiple systems of constraints, including fabrication, phylogeny and function. The tendency to place function above everything else has characterized some of the historical biological literature as a series of 'Just-So' stories that provided untested explanations for indiv...
Martin, Nora S Ahnert, Sebastian E
Published in
Journal of the Royal Society, Interface
The genotype-phenotype (GP) map of RNA secondary structure links each RNA sequence to its corresponding secondary structure. Previous research has shown that the large-scale structural properties of GP maps, such as the size of neutral sets in genotype space, can influence evolutionary outcomes. In order to use neutral set sizes, efficient and accu...
Jessen, Etienne Steinbach, Marc C Debbaut, Charlotte Schillinger, Dominik
Published in
Journal of the Royal Society, Interface
In this paper, we introduce a new framework for generating synthetic vascular trees, based on rigorous model-based mathematical optimization. Our main contribution is the reformulation of finding the optimal global tree geometry into a nonlinear optimization problem (NLP). This rigorous mathematical formulation accommodates efficient solution algor...
