Mamounas, Eleftherios P Bandos, Hanna Rastogi, Priya Lembersky, Barry C Jeong, Jong-Hyeon Geyer, Charles E Jr Fehrenbacher, Louis Chia, Stephen K Brufsky, Adam M Walshe, Janice M
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Published in
Journal of the National Cancer Institute
The National Surgical Adjuvant Breast and Bowel Project B-42 trial evaluated extended letrozole therapy (ELT) in postmenopausal breast cancer patients who were disease free after 5 years of aromatase inhibitor (AI)-based therapy. Seven-year results demonstrated a nonstatistically significant trend in disease-free survival (DFS) in favor of ELT. We ...
Berlin, Alejandro Ramotar, Matthew Santiago, Anna T Liu, Zhihui Li, Joyce Wolinsky, Howard Wallis, Christopher J D Chua, Melvin L K Paner, Gladell P van der Kwast, Theodorus
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Published in
Journal of the National Cancer Institute
Grade Group 1 (GG1) prostate cancer should be managed with active surveillance (AS). Global uptake of AS remains disappointingly slow and heterogeneous. Removal of cancer labels has been proposed to reduce GG1 overtreatment. We sought to determine the impact of GG1 disease terminology on individual's perceptions and decision making. Discrete choice...
Evans, Jason V Suman, Shankar Goruganthu, Mounika Uttam L Tchekneva, Elena E Guan, Shuxiao Arasada, Rajeswara Rao Antonucci, Anneliese Piao, Longzhu Ilgisonis, Irina Bobko, Andrey A
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Published in
Journal of the National Cancer Institute
We investigated the role of A2B-adenosine receptor in regulating immunosuppressive metabolic stress in the tumor microenvironment. Novel A2B-adenosine receptor antagonist PBF-1129 was tested for antitumor activity in mice and evaluated for safety and immunologic efficacy in a phase I clinical trial of patients with non-small cell lung cancer. The a...
Brooks, Gabriel A Tomaino, Marisa R Ramkumar, Niveditta Wang, Qianfei Kapadia, Nirav S O'Malley, A James Wong, Sandra L Loehrer, Andrew P Tosteson, Anna N A
Published in
Journal of the National Cancer Institute
Pancreatectomy is a necessary component of curative intent therapy for pancreatic cancer, and patients living in nonmetropolitan areas may face barriers to accessing timely surgical care. We evaluated the intersecting associations of rurality, socioeconomic status (SES), and race on treatment and outcomes of Medicare beneficiaries with pancreatic c...
Ramaswamy, Megha Manz, Christopher Kouyoumdjian, Fiona Vest, Noel Puglisi, Lisa Wang, Emily Salyer, Chelsea Osei, Beverly Zaller, Nick Rebbeck, Timothy R
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Published in
Journal of the National Cancer Institute
The cancer disparities between people with incarceration histories compared with those who do not have those histories are vast. Opportunities for bolstering cancer equity among those impacted by mass incarceration exist in criminal legal system policy; carceral, community, and public health linkages; better cancer prevention, screening, and treatm...
Bikomeye, Jean C Zhou, Yuhong McGinley, Emily L Canales, Bethany Yen, Tina W F Tarima, Sergey Ponce, Sara Beltrán Beyer, Kirsten M M
Published in
Journal of the National Cancer Institute
Breast cancer (BC) is the most common cancer among US women, and institutional racism is a critical cause of health disparities. We investigated impacts of historical redlining on BC treatment receipt and survival in the United States. Home Owners' Loan Corporation (HOLC) boundaries were used to measure historical redlining. Eligible women in the 2...
Lindström, Sara Wang, Lu Feng, Helian Majumdar, Arunabha Huo, Sijia Macdonald, James Harrison, Tabitha Turman, Constance Chen, Hongjie Mancuso, Nicholas
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Published in
Journal of the National Cancer Institute
The shared inherited genetic contribution to risk of different cancers is not fully known. In this study, we leverage results from 12 cancer genome-wide association studies (GWAS) to quantify pairwise genome-wide genetic correlations across cancers and identify novel cancer susceptibility loci. We collected GWAS summary statistics for 12 solid canc...
Chavez-MacGregor, Mariana Lei, Xiudong Malinowski, Catalina Zhao, Hui Shih, Ya-Chen Giordano, Sharon H
Published in
Journal of the National Cancer Institute
Medicaid expansion under the Affordable Care Act extends eligibility for participating states and has been associated with improved outcomes by facilitating access to care. Delayed initiation of adjuvant chemotherapy is associated with worse outcomes among patients with early-stage breast cancer (BC). The impact of Medicaid expansion in narrowing d...
Bandak, Mikkel Nielsen, Kristine Skovly Kreiberg, Michael Wagner, Thomas Rosenvilde, Josephine Pissinger, Charlotta Johansen, Christoffer Daugaard, Gedske Lauritsen, Jakob
Published in
Journal of the National Cancer Institute
We investigated the impact of smoking on overall survival (OS) in testicular germ cell cancer (TC) patients receiving first-line combination chemotherapy (bleomycin-etoposide-cisplatin [BEP]). Patients who received BEP for metastatic TC were identified in the Danish Testicular Cancer database. Information on smoking status at the time of diagnosis ...
Fournier, Agnès Cairat, Manon Severi, Gianluca Gunter, Marc J Rinaldi, Sabina Dossus, Laure
Published in
Journal of the National Cancer Institute
Epidemiological studies have found that menopausal hormone therapy (MHT) use is associated with an increased ovarian cancer risk. However, whether different MHT types confer the same level of risk is unclear. We estimated the associations between different MHT types and the risk of ovarian cancer in a prospective cohort. The study population includ...
