Zhu, Ping Qiu, Qi Harris, Peter C Xu, Xiaolei Lin, Xueying
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Journal of the American Society of Nephrology : JASN
Although zebrafish embryos have been used to study ciliogenesis and model polycystic kidney disease (PKD), adult zebrafish remain unexplored. Transcription activator-like effector nucleases (TALEN) technology was used to generate mutant for tmem67, the homolog of the mammalian causative gene for Meckel syndrome type 3 (MKS3). Classic 2D and optical...
Schold, Jesse D Mohan, Sumit Huml, Anne Buccini, Laura D Sedor, John R Augustine, Joshua J Poggio, Emilio D
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Journal of the American Society of Nephrology : JASN
Extensive research and policies have been developed to improve access to kidney transplantation among patients with ESKD. Despite this, wide variation in transplant referral rates exists between dialysis facilities. To evaluate the longitudinal pattern of access to kidney transplantation over the past two decades, we conducted a retrospective cohor...
Ayuzawa, Nobuhiro Fujita, Toshiro
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Journal of the American Society of Nephrology : JASN
Hypertension and its comorbidities pose a major public health problem associated with disease-associated factors related to a modern lifestyle, such high salt intake or obesity. Accumulating evidence has demonstrated that aldosterone and its receptor, the mineralocorticoid receptor (MR), have crucial roles in the development of salt-sensitive hyper...
Friedman, David J
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Journal of the American Society of Nephrology : JASN
Devalaraja-Narashimha, Kishor Meagher, Karoline Luo, Yifan Huang, Cong Kaplan, Theodore Muthuswamy, Anantharaman Halasz, Gabor Casanova, Sarah O'Brien, John Peyser Boiarsky, Rebecca
...
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Journal of the American Society of Nephrology : JASN
C3 glomerulopathy (C3G) is characterized by the alternative-pathway (AP) hyperactivation induced by nephritic factors or complement gene mutations. Mice deficient in complement factor H (CFH) are a classic C3G model, with kidney disease that requires several months to progress to renal failure. Novel C3G models can further contribute to understandi...
Toto, Robert Petersen, Jeffrey Berns, Jeffrey S Lewis, Eldrin Foster Tran, Qui Weir, Matthew R
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Journal of the American Society of Nephrology : JASN
Exposure to high doses or a high cumulative dose of erythropoiesis-stimulating agents (ESAs) may contribute to cardiovascular events in patients with CKD and anemia. Whether using a low fixed ESA dose versus dosing based on a hemoglobin-based, titration-dose algorithm in such patients might reduce risks associated with high ESA doses and decrease t...
Rudman-Melnick, Valeria Adam, Mike Potter, Andrew Chokshi, Saagar M Ma, Qing Drake, Keri A Schuh, Meredith P Kofron, J Matthew Devarajan, Prasad Potter, S Steven
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Journal of the American Society of Nephrology : JASN
Current management of AKI, a potentially fatal disorder that can also initiate or exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular pathways perturbed in AKI is needed to identify targets with potential to lead to improved treatment. We performed single-cell RNA sequencing (scRNA-seq) with the clinically relevan...
Yamamoto, Shinya Yamamoto, Masamichi Nakamura, Jin Mii, Akiko Yamamoto, Shigenori Takahashi, Masahiro Kaneko, Keiichi Uchino, Eiichiro Sato, Yuki Fukuma, Shingo
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Journal of the American Society of Nephrology : JASN
Depletion of ATP in renal tubular cells plays the central role in the pathogenesis of kidney diseases. Nevertheless, inability to visualize spatiotemporal in vivo ATP distribution and dynamics has hindered further analysis. A novel mouse line systemically expressing an ATP biosensor (an ATP synthase subunit and two fluorophores) revealed spatiotemp...
Chin, Ho Jun Chae, Dong-Wan Kim, Yong Chul An, Won Suk Ihm, ChunGyoo Jin, Dong-Chan Kim, Sung Gyun Kim, Yong-Lim Kim, Yong-Soo Kim, Yoon-Goo
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Journal of the American Society of Nephrology : JASN
Tacrolimus is used as a steroid-sparing immunosuppressant in adults with minimal change nephrotic syndrome. However, combined treatment with tacrolimus and low-dose steroid has not been compared with high-dose steroid for induction of clinical remission in a large-scale randomized study. In this 24-week open-label noninferiority study, we randomize...
Collard, Didier van de Velde, Lennart Vogt, Liffert van den Born, Bert-Jan H
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Journal of the American Society of Nephrology : JASN