QALYs, DALYs and Now PALYs: Strengthening the Argument for Prevention of CKD.
Published in Journal of the American Society of Nephrology : JASN
The Preventable Productivity Burden of Kidney Disease in Australia.
Published in Journal of the American Society of Nephrology : JASN
Kidney disease is associated with impaired work productivity. However, the collective effect of missed work days, reduced output at work, and early withdrawal from the workforce is rarely considered in health-economic evaluations. To determine the effect on work productivity of preventing incident cases of kidney disease, using the novel measure "p...
Data-driven Derivation and Validation of Novel Phenotypes for Acute Kidney Transplant Rejection using Semi-supervised Cl...
...Published in Journal of the American Society of Nephrology : JASN
Over the past decades, an international group of experts iteratively developed a consensus classification of kidney transplant rejection phenotypes, known as the Banff classification. Data-driven clustering of kidney transplant histologic data could simplify the complex and discretionary rules of the Banff classification, while improving the associ...
Crumbs2 Is an Essential Slit Diaphragm Protein of the Renal Filtration Barrier.
...Published in Journal of the American Society of Nephrology : JASN
Crumbs2 is expressed at embryonic stages as well as in the retina, brain, and glomerular podocytes. Recent studies identified CRB2 mutations as a novel cause of steroid-resistant nephrotic syndrome (SRNS). To study the function of Crb2 at the renal filtration barrier, mice lacking Crb2 exclusively in podocytes were generated. Gene expression and hi...
Rituximab or Cyclophosphamide in the Treatment of Membranous Nephropathy: The RI-CYCLO Randomized Trial.
...Published in Journal of the American Society of Nephrology : JASN
A cyclic corticosteroid-cyclophosphamide regimen is the first-line therapy for membranous nephropathy. Compared with this regimen, rituximab therapy might have a more favorable safety profile, but a head-to-head comparison is lacking. We randomly assigned 74 adults with membranous nephropathy and proteinuria >3.5 g/d to rituximab (1 g) on days 1 an...
Roxadustat for Renal Anemia in ESRD from PKD Patients: Is It Safe Enough?
Published in Journal of the American Society of Nephrology : JASN
Authors' Reply.
Published in Journal of the American Society of Nephrology : JASN
mtor Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish tmem67 Mutants.
Published in Journal of the American Society of Nephrology : JASN
Although zebrafish embryos have been used to study ciliogenesis and model polycystic kidney disease (PKD), adult zebrafish remain unexplored. Transcription activator-like effector nucleases (TALEN) technology was used to generate mutant for tmem67, the homolog of the mammalian causative gene for Meckel syndrome type 3 (MKS3). Classic 2D and optical...
Failure to Advance Access to Kidney Transplantation over Two Decades in the United States.
Published in Journal of the American Society of Nephrology : JASN
Extensive research and policies have been developed to improve access to kidney transplantation among patients with ESKD. Despite this, wide variation in transplant referral rates exists between dialysis facilities. To evaluate the longitudinal pattern of access to kidney transplantation over the past two decades, we conducted a retrospective cohor...
The Mineralocorticoid Receptor in Salt-Sensitive Hypertension and Renal Injury.
Published in Journal of the American Society of Nephrology : JASN
Hypertension and its comorbidities pose a major public health problem associated with disease-associated factors related to a modern lifestyle, such high salt intake or obesity. Accumulating evidence has demonstrated that aldosterone and its receptor, the mineralocorticoid receptor (MR), have crucial roles in the development of salt-sensitive hyper...
