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mtor Haploinsufficiency Ameliorates Renal Cysts and Cilia Abnormality in Adult Zebrafish tmem67 Mutants.

Published in Journal of the American Society of Nephrology : JASN

Although zebrafish embryos have been used to study ciliogenesis and model polycystic kidney disease (PKD), adult zebrafish remain unexplored. Transcription activator-like effector nucleases (TALEN) technology was used to generate mutant for tmem67, the homolog of the mammalian causative gene for Meckel syndrome type 3 (MKS3). Classic 2D and optical...

Failure to Advance Access to Kidney Transplantation over Two Decades in the United States.

Published in Journal of the American Society of Nephrology : JASN

Extensive research and policies have been developed to improve access to kidney transplantation among patients with ESKD. Despite this, wide variation in transplant referral rates exists between dialysis facilities. To evaluate the longitudinal pattern of access to kidney transplantation over the past two decades, we conducted a retrospective cohor...

The Mineralocorticoid Receptor in Salt-Sensitive Hypertension and Renal Injury.

Published in Journal of the American Society of Nephrology : JASN

Hypertension and its comorbidities pose a major public health problem associated with disease-associated factors related to a modern lifestyle, such high salt intake or obesity. Accumulating evidence has demonstrated that aldosterone and its receptor, the mineralocorticoid receptor (MR), have crucial roles in the development of salt-sensitive hyper...

COVID-19 and APOL1: Understanding Disease Mechanisms through Clinical Observation.

Published in Journal of the American Society of Nephrology : JASN

Humanized C3 Mouse: A Novel Accelerated Model of C3 Glomerulopathy.

Published in Journal of the American Society of Nephrology : JASN

C3 glomerulopathy (C3G) is characterized by the alternative-pathway (AP) hyperactivation induced by nephritic factors or complement gene mutations. Mice deficient in complement factor H (CFH) are a classic C3G model, with kidney disease that requires several months to progress to renal failure. Novel C3G models can further contribute to understandi...

A Randomized Trial of Strategies Using Darbepoetin Alfa To Avoid Transfusions in CKD.

Published in Journal of the American Society of Nephrology : JASN

Exposure to high doses or a high cumulative dose of erythropoiesis-stimulating agents (ESAs) may contribute to cardiovascular events in patients with CKD and anemia. Whether using a low fixed ESA dose versus dosing based on a hemoglobin-based, titration-dose algorithm in such patients might reduce risks associated with high ESA doses and decrease t...

Single-Cell Profiling of AKI in a Murine Model Reveals Novel Transcriptional Signatures, Profibrotic Phenotype, and Epit...

Published in Journal of the American Society of Nephrology : JASN

Current management of AKI, a potentially fatal disorder that can also initiate or exacerbate CKD, is merely supportive. Therefore, deeper understanding of the molecular pathways perturbed in AKI is needed to identify targets with potential to lead to improved treatment. We performed single-cell RNA sequencing (scRNA-seq) with the clinically relevan...

Spatiotemporal ATP Dynamics during AKI Predict Renal Prognosis.

Published in Journal of the American Society of Nephrology : JASN

Depletion of ATP in renal tubular cells plays the central role in the pathogenesis of kidney diseases. Nevertheless, inability to visualize spatiotemporal in vivo ATP distribution and dynamics has hindered further analysis. A novel mouse line systemically expressing an ATP biosensor (an ATP synthase subunit and two fluorophores) revealed spatiotemp...

Comparison of the Efficacy and Safety of Tacrolimus and Low-Dose Corticosteroid with High-Dose Corticosteroid for Minima...

Published in Journal of the American Society of Nephrology : JASN

Tacrolimus is used as a steroid-sparing immunosuppressant in adults with minimal change nephrotic syndrome. However, combined treatment with tacrolimus and low-dose steroid has not been compared with high-dose steroid for induction of clinical remission in a large-scale randomized study. In this 24-week open-label noninferiority study, we randomize...

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Published in Journal of the American Society of Nephrology : JASN