Olaniran, Kabir O Allegretti, Andrew S Zhao, Sophia H Achebe, Maureen M Eneanya, Nwamaka D Thadhani, Ravi I Nigwekar, Sagar U Kalim, Sahir
Published in
Journal of the American Society of Nephrology : JASN
Sickle cell trait and sickle cell disease are thought to be independent risk factors for CKD, but the trajectory and predictors of kidney function decline in patients with these phenotypes are not well understood. Our multicenter, observational study used registry data (collected January 2005 through June 2018) and included adult black patients wit...
Ezekian, Brian Schroder, Paul M Mulvihill, Michael S Barbas, Andrew Collins, Bradley Freischlag, Kyle Yoon, Janghoon Yi, John S Smith, Felicitas Olaso, Danae
...
Published in
Journal of the American Society of Nephrology : JASN
Patients with broad HLA sensitization have poor access to donor organs, high mortality while waiting for kidney transplant, and inferior graft survival. Although desensitization strategies permit transplantation via lowering of donor-specific antibodies, the B cell-response axis from germinal center activation to plasma cell differentiation remains...
Gorbacheva, Victoria Fan, Ran Beavers, Ashley Fairchild, Robert L Baldwin, William M 3rd Valujskikh, Anna
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Journal of the American Society of Nephrology : JASN
The mechanisms underlying the effects of prolonged cold-ischemia storage on kidney allografts are poorly understood. To investigate effects of cold ischemia on donor-reactive immune responses and graft pathology, we used a mouse kidney transplantation model that subjected MHC-mismatched BALB/c kidney allografts to cold-ischemia storage for 0.5 or 6...
Kormann, Raphaёl Kavvadas, Panagiotis Placier, Sandrine Vandermeersch, Sophie Dorison, Aude Dussaule, Jean-Claude Chadjichristos, Christos E Prakoura, Niki Chatziantoniou, Christos
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Journal of the American Society of Nephrology : JASN
The matricellular protein periostin has been associated with CKD progression in animal models and human biopsy specimens. Periostin functions by interacting with extracellular matrix components to drive collagen fibrillogenesis and remodeling or by signaling through cell-surface integrin receptors to promote cell adhesion, migration, and proliferat...
Collins, Michael G Symonds, Erin L Bampton, Peter A Coates, P Toby
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Journal of the American Society of Nephrology : JASN
Odobasic, Dragana Oudin, Virginie Ito, Kenji Gan, Poh-Yi Kitching, A Richard Holdsworth, Stephen R
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Journal of the American Society of Nephrology : JASN
Background Because of their capacity to induce antigen-specific immunosuppression, tolerogenic dendritic cells are a promising tool for treatment of autoimmune conditions, such as GN caused by autoimmunity against myeloperoxidase (MPO). We sought to generate tolerogenic dendritic cells to suppress anti-MPO GN by culturing bone marrow cells with an ...
Wong, Germaine Hope, Richard L Howard, Kirsten Chapman, Jeremy R Castells, Antoni Roger, Simon D Bourke, Michael J Macaskill, Petra Turner, Robin Williams, Gabrielle
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Published in
Journal of the American Society of Nephrology : JASN
Chertow, Glenn M Beddhu, Srinivasan
Published in
Journal of the American Society of Nephrology : JASN
Delanaye, Pierre Jager, Kitty J Bökenkamp, Arend Christensson, Anders Dubourg, Laurence Eriksen, Bjørn Odvar Gaillard, François Gambaro, Giovanni van der Giet, Markus Glassock, Richard J
...
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Journal of the American Society of Nephrology : JASN
Current criteria for the diagnosis of CKD in adults include persistent signs of kidney damage, such as increased urine albumin-to-creatinine ratio or a GFR below the threshold of 60 ml/min per 1.73 m2 This threshold has important caveats because it does not separate kidney disease from kidney aging, and therefore does not hold for all ages. In an e...
Grams, Morgan E Surapaneni, Aditya Ballew, Shoshana H Appel, Lawrence J Boerwinkle, Eric Boulware, L Ebony Chen, Teresa K Coresh, Josef Cushman, Mary Divers, Jasmin
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Published in
Journal of the American Society of Nephrology : JASN
Two coding variants in the apo L1 gene (APOL1) are strongly associated with kidney disease in blacks. Kidney disease itself increases the risk of cardiovascular disease, but whether these variants have an independent direct effect on the risk of cardiovascular disease is unclear. Previous studies have had inconsistent results. We conducted a two-st...
