Trepiccione, Francesco Gerber, Simon D Grahammer, Florian López-Cayuqueo, Karen I Baudrie, Véronique Păunescu, Teodor G Capen, Diane E Picard, Nicolas Alexander, R Todd Huber, Tobias B
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Published in
Journal of the American Society of Nephrology
ATPase H+-transporting lysosomal accessory protein 2 (Atp6ap2), also known as the (pro)renin receptor, is a type 1 transmembrane protein and an accessory subunit of the vacuolar H+-ATPase (V-ATPase) that may also function within the renin-angiotensin system. However, the contribution of Atp6ap2 to renin-angiotensin-dependent functions remains uncon...
Amrouche, Lucile Desbuissons, Geoffroy Rabant, Marion Sauvaget, Virginia Nguyen, Clément Benon, Aurélien Barre, Pauline Rabaté, Clémentine Lebreton, Xavier Gallazzini, Morgan
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Published in
Journal of the American Society of Nephrology
AKI leads to tubular injury and interstitial inflammation that must be controlled to avoid the development of fibrosis. We hypothesized that microRNAs are involved in the regulation of the balance between lesion formation and adaptive repair. We found that, under proinflammatory conditions, microRNA-146a (miR-146a) is transcriptionally upregulated ...
Aboudehen, K. Kim, M. S. Mitsche, M. Garland, K. Anderson, N. Noureddine, L. Marco Pontoglio Patel, V. Xie, Y. DeBose-Boyd, R.
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Published in
Journal of the American Society of Nephrology
HNF-1β is a tissue-specific transcription factor that is expressed in the kidney and other epithelial organs. Humans with mutations in HNF-1β develop kidney cysts, and HNF-1β regulates the transcription of several cystic disease genes. However, the complete spectrum of HNF-1β-regulated genes and pathways is not known. Here, using chromatin immunopr...
Bienaime, F. Muorah, M. Yammine, L. Burtin, M. Nguyen, C. Baron, W. Garbay, S. Viau, A. Broueilh, M. Blanc, T.
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Published in
Journal of the American Society of Nephrology
In CKD, tubular cells may be involved in the induction of interstitial fibrosis, which in turn, leads to loss of renal function. However, the molecular mechanisms that link tubular cells to the interstitial compartment are not clear. Activation of the Stat3 transcription factor has been reported in tubular cells after renal damage, and Stat3 has be...
Kruzel-Davila, Etty Shemer, Revital Ofir, Ayala Bavli-Kertselli, Ira Darlyuk-Saadon, Ilona Oren-Giladi, Pazit Wasser, Walter G. Magen, Daniella Zaknoun, Eid Schuldiner, Maya
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Published in
Journal of the American Society of Nephrology
APOL1 harbors C-terminal sequence variants (G1 and G2), which account for much of the increased risk for kidney disease in sub-Saharan African ancestry populations. Expression of the risk variants has also been shown to cause injury to podocytes and other cell types, but the underlying mechanisms are not understood. We used Drosophila melanogaster ...
Delville, Marianne Baye, Emilie Durrbach, Antoine Audard, Vincent Kofman, Tomek Braun, Laura Olagne, Jérôme Nguyen, Clément Deschênes, Georges Moulin, Bruno
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Published in
Journal of the American Society of Nephrology
FSGS is a common glomerular disorder that has a high propensity for recurrence after kidney transplant. The pathophysiology of FSGS is unknown, but podocytes seem to be the target of one or several circulating factors that lead to cytoskeleton reorganization and proteinuria. Research on podocytes has identified B7-1 as an important factor in podocy...
Aboudehen, Karam Kim, Min Soo Mitsche, Matthew Garland, Kristina Anderson, Norma Noureddine, Lama Marco Pontoglio Patel, Vishal Xie, Yang DeBose-Boyd, Russell
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Published in
Journal of the American Society of Nephrology
HNF-1β is a tissue-specific transcription factor that is expressed in the kidney and other epithelial organs. Humans with mutations in HNF-1β develop kidney cysts, and HNF-1β regulates the transcription of several cystic disease genes. However, the complete spectrum of HNF-1β-regulated genes and pathways is not known. Here, using chromatin immunopr...
Rabant, M. Amrouche, L. Lebreton, X. Aulagnon, F. Benon, A. Sauvaget, V. Bonifay, R. Morin, L. Scemla, A. Delville, M.
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Published in
Journal of the American Society of Nephrology
Urinary levels of C-X-C motif chemokine 9 (CXCL9) and CXCL10 can noninvasively diagnose T cell-mediated rejection (TCMR) of renal allografts. However, performance of these molecules as diagnostic/prognostic markers of antibody-mediated rejection (ABMR) is unknown. We investigated urinary CXCL9 and CXCL10 levels in a highly sensitized cohort of 244 ...
Huynh Cong, Evelyne Bizet, Albane A Boyer, Olivia Woerner, Stéphanie Gribouval, Olivier Filhol, Emilie Arrondel, Christelle Thomas, Sophie Silbermann, Flora Canaud, Guillaume
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Published in
Journal of the American Society of Nephrology
Several genes, mainly involved in podocyte cytoskeleton regulation, have been implicated in familial forms of primary FSGS. We identified a homozygous missense mutation (p.P209L) in the TTC21B gene in seven families with FSGS. Mutations in this ciliary gene were previously reported to cause nephronophthisis, a chronic tubulointerstitial nephropathy...
Canaud, Guillaume Dejucq-Rainsford, Nathalie Avettand-Fenoël, Véronique Viard, Jean-Paul Anglicheau, Dany Bienaimé, Frank Muorah, Mordi Galmiche, Louise Gribouval, Olivier Noël, Laure-Helene
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Published in
Journal of the American Society of Nephrology
Since the recent publication of data showing favorable outcomes for patients with HIV-1 and ESRD, kidney transplantation has become a therapeutic option in this population. However, reports have documented unexplained reduced allograft survival in these patients. We hypothesized that the unrecognized infection of the transplanted kidney by HIV-1 ca...
