Miyamoto, Kazunori Saito, Motomichi Tsuji, Shunsuke Takagi, Taisei Shiro, Motoo Uchiyama, Masanobu Ochiai, Masahito
Published in
Journal of the American Chemical Society
We present the first synthesis of air/moisture-stable λ3-bromanes (9 and 10) by using a cyclic 1,2-benzbromoxol-3-one (BBX) strategy. X-ray crystallography and NMR and IR spectroscopy of N-triflylimino-λ3-bromane (12) revealed that the bromine(III) center is effectively stabilized by intramolecular R-Br-O hypervalent bonding. This strategy enables ...
Vang, Zoua Pa Reyes, Albert Sonstrom, Reilly E Holdren, Martin S Sloane, Samantha E Alansari, Isabella Y Neill, Justin L Pate, Brooks H Clark, Joseph R
Published in
Journal of the American Chemical Society
A copper-catalyzed alkene transfer hydrodeuteration reaction that selectively incorporates one hydrogen and one deuterium atom across an aryl alkene is described. The transfer hydrodeuteration protocol is selective across a variety of internal and terminal alkenes and is also demonstrated on an alkene-containing complex natural product analog. Beyo...
Deng, Haiqiang Peljo, Pekka Huang, Xinjian Smirnov, Evgeny Sarkar, Sujoy Maye, Sunny Girault, Hubert H Mandler, Daniel
Published in
Journal of the American Chemical Society
Emulsification of immiscible two-phase fluids, i.e., one condensed phase dispersed homogeneously as tiny droplets in an outer continuous medium, plays a key role in medicine, food, chemical separations, cosmetics, fabrication of micro- and nanoparticles and capsules, and dynamic optics. Herein, we demonstrate that water clusters/droplets can be for...
Amero, Paola Lokesh, Ganesh L R Chaudhari, Rajan R Cardenas-Zuniga, Roberto Schubert, Thomas Attia, Yasmin M Montalvo-Gonzalez, Efigenia Elsayed, Abdelrahman M Ivan, Cristina Wang, Zhihui
...
Published in
Journal of the American Chemical Society
Aptamers, synthetic single-strand oligonucleotides that are similar in function to antibodies, are promising as therapeutics because of their minimal side effects. However, the stability and bioavailability of the aptamers pose a challenge. We developed aptamers converted from RNA aptamer to modified DNA aptamers that target phospho-AXL with improv...
Dregni, Aurelio J Wang, Harrison K Wu, Haifan Duan, Pu Jin, Jia DeGrado, William F Hong, Mei
Published in
Journal of the American Chemical Society
Many neurodegenerative diseases such as Alzheimer's disease are characterized by pathological β-sheet filaments of the tau protein, which spread in a prion-like manner in patient brains. To date, high-resolution structures of tau filaments obtained from patient brains show that the β-sheet core only includes portions of the microtubule-binding repe...
Kriebisch, Christine M E Bergmann, Alexander M Boekhoven, Job
Published in
Journal of the American Chemical Society
In dynamic combinatorial libraries, molecules react with each other reversibly to form intricate networks under thermodynamic control. In biological systems, chemical reaction networks operate under kinetic control by the transduction of chemical energy. We thus introduced the notion of energy transduction, via chemical reaction cycles, to a dynami...
Pálmadóttir, Tinna Malmendal, Anders Leiding, Thom Lund, Mikael Linse, Sara
Published in
Journal of the American Chemical Society
Electrostatic interactions play crucial roles in protein function. Measuring pKa value perturbations upon complex formation or self-assembly of e.g. amyloid fibrils gives valuable information about the effect of electrostatic interactions in those processes. Site-specific pKa value determination by solution NMR spectroscopy is challenged by the hig...
Wu, Zhenyue Zhang, Weichuan Ye, Huang Yao, Yunpeng Liu, Xitao Li, Lina Ji, Chengmin Luo, Junhua
Published in
Journal of the American Chemical Society
High-Curie-temperature (Tc) ferroelectrics have exhibited broad applications in optoelectronic devices. Recently, two-dimensional multilayered perovskite ferroelectrics with excellent photoelectric attributes are attracting increasing interest as new systems of photoferroelectrics. However, the effective tuning of the Tc value of a multilayered per...
Yang, Mingfang Wang, Shi-Qiang Liu, Zhaoyi Chen, Yao Zaworotko, Michael J Cheng, Peng Ma, Jian-Gong Zhang, Zhenjie
Published in
Journal of the American Chemical Society
It is of profound significance with regard to the global energy crisis to develop new techniques and materials that can convert the chemical potential of water into other forms of energy, especially electricity. To address this challenge, we built a new type of energy transduction pathway (humidity gradients → mechanical work → electrical power) us...
Guo, Wusheng Zuo, Linhong Cui, Manying Yan, Biwei Ni, Shaofei
Published in
Journal of the American Chemical Society
A propargylic amination approach toward chiral acyclic α-quaternary α-amino ketones is described. This Cu-catalyzed procedure could be performed open to air using commercially available amines as nucleophiles. The key to success is the use of rationally designed propargylic cyclic carbonates as substrates, which can generate a Cu-bonded enolate zwi...
