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Mechanism of Color and Photoacidity Tuning for the Protonated Green Fluorescent Protein Chromophore.

Published in Journal of the American Chemical Society

The neutral or A state of the green fluorescent protein (GFP) chromophore is a remarkable example of a photoacid naturally embedded in the protein environment and accounts for the large Stokes shift of GFP in response to near UV excitation. Its color tuning mechanism has been largely overlooked, as it is less preferred for imaging applications than...

UvrC Coordinates an O2-Sensitive [4Fe4S] Cofactor.

Published in Journal of the American Chemical Society

Recent advances have led to numerous landmark discoveries of [4Fe4S] clusters coordinated by essential enzymes in repair, replication, and transcription across all domains of life. The cofactor has notably been challenging to observe for many nucleic acid processing enzymes due to several factors, including a weak bioinformatic signature of the coo...

Reversible Electrochemical Gelation of Metal Chalcogenide Quantum Dots.

Published in Journal of the American Chemical Society

The ability to dictate the assembly of quantum dots (QDs) is critical for their integration into solid-state electronic and optoelectronic devices. However, assembly methods that enable efficient electronic communication between QDs, facilitate access to the reactive surface, and retain the native quantum confinement characteristics of the QD are l...

Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Fou...

Published in Journal of the American Chemical Society

The potent DNA-binding compound triaminotriazine-acridine conjugate (Z1) functions by targeting T:T mismatches in CTG trinucleotide repeats that are responsible for causing neurological diseases such as myotonic dystrophy type 1, but its binding mechanism remains unclear. We solved a crystal structure of Z1 in a complex with DNA containing three co...

Triplet Energy Transfer from Perovskite Nanocrystals Mediated by Electron Transfer.

Published in Journal of the American Chemical Society

Triplet energy transfer from colloidal nanocrystals is a novel approach to sensitizing molecular triplets that are important for many applications. Recent studies suggest that this triplet transfer can be mediated by a hole transfer process when it is energetically allowed. In contrast, electron-transfer-mediated triplet transfer has not been obser...

Protein-Protein Cross-Coupling via Palladium-Protein Oxidative Addition Complexes from Cysteine Residues.

Published in Journal of the American Chemical Society

Few chemical methods exist for the covalent conjugation of two proteins. We report the preparation of site-specific protein-protein conjugates that arise from the sequential cross-coupling of cysteine residues on two different proteins. The method involves the synthesis of stable palladium-protein oxidative addition complexes (Pd-protein OACs), a p...

Bent-Shaped p-Type Small Molecule Organic Semiconductors: A Molecular Design Strategy for Next-Generation Practical Appl...

Published in Journal of the American Chemical Society

Significant progress has been made in both molecular design and fundamental scientific understanding of organic semiconductors (OSCs) in recent years. Suitable charge-carrier mobilities (µ) have been obtained by many high-performance OSCs (µ > 10 cm2 V 1 s 1), but drawbacks remain, including low solution processability and poor thermal durability. ...

Pagoda[4]arene and i-Pagoda[4]arene.

Published in Journal of the American Chemical Society

A new type of macrocyclic arenes, named as pagoda[4]arene (P4) and i-pagoda[4]arene (i-P4), were conveniently synthesized by TFA-catalyzed one-pot condensation of 2,6-dimethoxylanthracene and paraformaldehyde in dichloromethane at room temperature. P4 and i-P4 showed unique square pagoda structures and fixed conformations in solution, and also exhi...

Cp 2Ti( κ 2 - t BuNCN t Bu): a Complex With an Unusual κ 2 Coordination Mode of a Heterocumulene Featuring a Free Carben...

Published in Journal of the American Chemical Society