Assemat, Gaëtan Balayssac, Stéphane Gilard, Véronique Martins-Froment, Nathalie Fabing, Isabelle Rodriguez, Frédéric Génisson, Yves Martino, Robert Malet-Martino, Myriam
Published in
Journal of pharmaceutical and biomedical analysis
A sexual enhancer dietary supplement in pre-commercialization phase was analyzed. It contained the two phosphodiesterase-5 inhibitors (PDE-5i) sildenafil and methisosildenafil as major adulterants. Fourteen more sildenafil derivatives were detected and after isolation, their structures were elucidated thanks to NMR, high resolution and tandem mass ...
Fan, Yingying Noreldeen, Hamada A A You, Lei Liu, Xinyu Pan, Xue Hou, Zhichao Li, Qiangming Li, Xiangnan Xu, Guowang
Published in
Journal of pharmaceutical and biomedical analysis
High morbidity and mortality are still associated with lung cancer, especially non-small cell lung cancer (NSCLC). Although several studies showed abnormality in lung cancer lipidome, the underlying mechanism remains unclear. Therefore, a marker for early diagnosis of NSCLC is highly needed. In this study, a nontargeted lipidomics approach based on...
Aydın, Elif Burcu Aydın, Muhammet Sezgintürk, Mustafa Kemal
Published in
Journal of pharmaceutical and biomedical analysis
A new flexible biosensor based on conjugated polymer functionalized indium tin oxide (ITO) sheet was fabricated for Receptor for Activated C Kinase 1 (RACK 1) determination. Poly(3-thiophene acetic acid) (P(Thi-Ac)) was used as an immobilization matrix for construction of RACK 1 immunosensor. This polymer had a great number of carboxyl groups on it...
Guo, Ting Li, Weimiao Qian, Lu Yan, Xiaolong Cui, Daxiang Zhao, Jinbo Ni, Haibin Zhao, Xiangwei Zhang, Zhipei Li, Xiaofei
...
Published in
Journal of pharmaceutical and biomedical analysis
The evaluation of EGFR mutation genes in circulating tumor DNA (ctDNA) in blood sample is key for patients with lung cancer. Surface-enhanced Raman scattering (SERS) has potential for trace detection of DNA or RNA. The detection rate offered by current methods can not meet clinical demand. By combining asymmetric polymerase chain reaction (PCR) and...
Martínez-Chávez, Alejandra Tibben, Matthijs M Broeders, Jelle Rosing, Hilde Schinkel, Alfred H Beijnen, Jos H
Published in
Journal of pharmaceutical and biomedical analysis
Milciclib is a promising cyclin-dependent kinase inhibitor currently in phase II clinical trials to treat several types of cancer. The first bioanalytical method for the quantitative analysis of milciclib in several biomatrices using liquid chromatography-tandem mass spectrometry is described here. This method was fully validated in human plasma ac...
Chang, Nianwei Gao, Jie Niu, Lin Hou, Yuanyuan Wang, Xiaoying Jiang, Min Bai, Gang
Published in
Journal of pharmaceutical and biomedical analysis
Arrhythmia, a common heart disease, is an abnormal frequency or rhythm of heartbeat caused by the origin or conduction obstacle of the heart. Aconite (Fuzi) has been regarded as an effective cardiotonic agent in traditional Chinese medicine (TCM), but it sometimes induces cardiac toxicity, such as arrhythmia, in the clinic. It is still a challenge ...
Zhang, Zhihao Yang, Ming Yin, Ailing Chen, Minmin Tan, Ninghua Wang, Majie Zhang, Yanke Ye, Hesong Zhang, Xuefeng Zhou, Wei
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Published in
Journal of pharmaceutical and biomedical analysis
Stress urinary incontinence (SUI), which is defined as an involuntary loss of urine upon physical exertion coughing, sneezing or laughing, has a significant negative impact on the quality of life of many women. Multi-center, large-scale and randomized clinical trials have illustrated that non-invasive electroacupuncture is an effective treatment fo...
Zhang, Guanhua Wang, Qi Liu, Xin Wang, Xu Xie, Wenyu Liu, Kun Jiang, Wujun Mu, Chenglin Qi, Huanyang Wang, Qiao
...
Published in
Journal of pharmaceutical and biomedical analysis
The "multi-component and multi-target" property of traditional Chinese medicine (TCM) makes the quality control more difficult, which remains a key concern hindering the space of progress in its modernization and globalization. This study aims to provide a new strategy to discover quality markers related to the efficacy and stability of TCM based o...
Guoning, Chen Hua, Shu Wang, Lu Qianqian, Hu Xia, Cui Hongge, Zhu Zhimin, Luo Chun, Chang Qiang, Fu
Published in
Journal of pharmaceutical and biomedical analysis
Molecularly imprinted polymers have demonstrated tremendous potential in the immunoassay as alternatives to biological antibodies. However, the production of molecularly imprinted polymers for protein remains great challenges because of structural complexity and organic solvent instability. In addition, non-specific binding sites in the molecularly...
Capiau, Sara Stove, Christophe
Published in
Journal of pharmaceutical and biomedical analysis
Recently, volumetric absorptive microsampling (VAMS) has been suggested as an alternative to DBS sampling. With VAMS, a fixed volume of blood (approximately 10 μL) is wicked up by the absorbent tip of a collection device, independent of the hematocrit (HT) of the blood sample. This way, VAMS effectively avoids the HT bias which occurs in partial-pu...
