Han, Chang Tan, Dongqin Wang, Yue Yu, Zhonglin Sun, Xiaoli Wang, Degao
Published in
Journal of pharmaceutical and biomedical analysis
Dummy molecularly imprinted polymers (DMIPs) for selective extraction of five common synthetic cathinones (SCs) were prepared by bulk polymerization. DMIPs materials possessed narrow diameter distribution (30-60 µm) and large specific surface area (329.6 m2 g-1). Imprinting factors for cathinone, methcathinone, mephedrone, methylone and ethylone we...
Adhikari, Sarju Rustum, Abu M
Published in
Journal of pharmaceutical and biomedical analysis
Eprinomectin (EPM) is a semi-synthetic potent antiparasitic drug widely used in veterinary medicine. In this study, a comprehensive forced degradation study was carried out on EPM drug substance as per ICH guidelines. Generation of adequate quantities of major degradation products of EPM via forced degradation studies was necessary for identificati...
Zhang, Bin Wang, Yadong Xu, Chao Wang, Yue Wang, Xiaolin Wang, Fuchao Wang, Yaling Yin, Hongzong
Published in
Journal of pharmaceutical and biomedical analysis
Tumor cell heterogeneity determines the prognosis and metastasis of the tumor. It is pivotal to develop an innovative and facile cell imaging probe for cell and tumor tissue imaging. Combined the fluorescent properties, enzyme-like catalytic activity of Au nanocluster materials and the catalytic activity of Iron-based nanoparticles to establish an ...
Mahdavijalal, Mohammadreza Panahi, Homayon Ahmad Niazi, Ali Tamaddon, Atefeh
Published in
Journal of pharmaceutical and biomedical analysis
Bicalutamide (BLT), a non-steroidal anti-androgen, is widely used in patients with advanced prostate cancer. This study aimed to synthesize a smart modified nano-adsorbent (SMNA) based on tungsten disulfide (WS2) for solid-phase extraction of BLT from human plasma and urine samples. Briefly, we increased drug loading capacity of SMNA through the po...
Jiang, Jing Hu, Zhao-Liang Boucetta, Hamza Liu, Jia-Ming Song, Min Hang, Tai-Jun Lu, Yu-Ting
Published in
Journal of pharmaceutical and biomedical analysis
Flumazenil is an imidazobenzodiazepine derivative that antagonizes the actions of benzodiazepines. The degradation pathway elucidation plays an important role in the drug quality control. In this work, a reliable LC-Q-TOF/MS method was developed to separate and identify the degradation products of flumazenil generated in the stress testing conducte...
Mokhtari, Mehdi Rahimpour, Elaheh Jouyban-Gharamaleki, Vahid Khoubnasabjafari, Maryam Hosseini, Mohammadbagher Jouyban, Abolghasem
Published in
Journal of pharmaceutical and biomedical analysis
In this study, a fluorometric probe based on luminol-terbium coordination polymer nanoparticles (luminol-Tb CP NPs) is validated for the quantification of phenobarbital in the exhaled breath condensate collected from expiratory circuit of the mechanical ventilator (MVEBC). It relies on the coordination of phenobarbital to luminol-Tb CP NPs which ca...
Ciza, P H Sacre, P-Y Waffo, C Kimbeni, T M Masereel, B Hubert, Ph Ziemons, E Marini, R D
Published in
Journal of pharmaceutical and biomedical analysis
Chemometrics applied to spectroscopic measurements such as near-infrared are gaining more and more importance for quality control of pharmaceutical products. Handheld near-infrared devices show great promise as a medicines quality screening technique for post-marketing surveillance. These devices are able to detect substandard and falsified medicin...
Liu, Xiaoran Roger Huang, Richard Y-C Zhao, Feifei Chen, Guodong Tao, Li
Published in
Journal of pharmaceutical and biomedical analysis
Monoclonal antibody (mAb) has grown to be the major asset in protein therapeutics market since its initial introduction in 1980s. To identify a suitable mAb as a drug candidate for development requires deep understanding of disease biology and attribute sciences, including epitope-paratope binding recognition. Mass spectrometry (MS) has become a cr...
Rajput, Niraj Soni, Fatema Sahu, Amit Kumar Jadav, Tarang Sharma, Satyasheel Sengupta, Pinaki
Published in
Journal of pharmaceutical and biomedical analysis
Binimetinib (BMT) has recently been approved by the USFDA for the treatment of melanomas. An extensive literature search revealed that degradation kinetics of BMT is not reported in any scientific report. Till date, no stability indicating analytical method (SIAM) is available for quantification of BMT in presence of its impurities. Moreover, infor...
Wang, Huanhuan Zhang, Lishi Zhang, Xiaoran Song, Jiannan Guo, Qin Zhang, Xude Bai, Dong
Published in
Journal of pharmaceutical and biomedical analysis
Atherosclerosis (AS) is a progressive disease with a complex pathogenesis which is characterized by dyslipidemia and changes in the vascular wall composition. According to the degree of lesions, atherosclerosis can be divided into four stages: hyperlipidemia, lipid stria, fiber plaque, and atherosclerotic plaque. The present study aimed to establis...
