Srivatsa, Koduru Gokhale, Yatika Chakrabarti, Partha Pratim Kulshrestha, Abhishek Vajpai, Navratna
Published in
Journal of pharmaceutical and biomedical analysis
High molecular weight protein aggregates present in a recombinant human insulin and analogs are conventionally quantified by SEC-HPLC and identified by SEC-MALS as oligomeric population which lacks precise identification of species. The limitation of these two techniques is vanquished though simultaneous separation and identification by SEC coupled...
Waffo Tchounga, C A Sacre, P Y Ciza, P Ngono, R Ziemons, E Hubert, Ph Marini, R D
Published in
Journal of pharmaceutical and biomedical analysis
The proliferation of falsified medicines can cause serious public health issues, particularly in the context of a global pandemic such as the actual COVID-19 pandemic. Our study involved eight chloroquine phosphate medicines seized in Cameroon, Democratic Republic of Congo and Niger during March and May 2020. These suspect samples were first analyz...
Perruchon, Olivier Schmitz-Afonso, Isabelle Grondin, Cécile Casaregola, Serge Afonso, Carlos Elomri, Abdelhakim
Published in
Journal of pharmaceutical and biomedical analysis
Natural products are a reliable source of bioactive molecules and represent an industrial and pharmaceutical stake. Indeed, the model yeast species Saccharomyces cerevisiae is a well-known eukaryotic organism largely used as a biotechnological tool, but still a topical subject of study. In this work, the exploration of Saccharomyces cerevisiae is t...
Yang, Rong Ren, Shuang Jin, Xiaowei Sun, Yu Dong, Yanli Zhang, Jinwei Liang, Wenzhong Chen, Li
Published in
Journal of pharmaceutical and biomedical analysis
Dorzagliatin, a novel glucokinase (GK) activator targeting both pancreatic and hepatic GK, is currently in late-stage clinical development for treatment of type 2 diabetes (T2D). For the optimization of dosing regimens to ensure adequate safety and efficacy, it is critical to have a deep understanding of pharmacokinetic (PK) and pharmacodynamic (PD...
Jeelani, Salika Soukhova, Nadejda
Published in
Journal of pharmaceutical and biomedical analysis
A rapid, sensitive, and accurate high-performance liquid chromatography (HPLC) method was developed and validated for the separation and analysis of organic impurities in erythromycin stearate tablets. The method separates Erythromycin, Erythromycin B, Erythromycin C and nine impurities (EP Impurity A, B, C, D, E, F, H, I and M). The chromatographi...
Malo, Andisiwe Kellermann, Tracy Ignatius, Elisa H Dooley, Kelly E Dawson, Rodney Joubert, Anton Norman, Jennifer Castel, Sandra Wiesner, Lubbe
Published in
Journal of pharmaceutical and biomedical analysis
A method for the extraction and quantification of pretomanid in 40 μL of human plasma, by high performance liquid chromatography with tandem mass spectrometry (LC-MS/MS) detection was developed and validated. Samples were prepared using liquid-liquid extraction and chromatographic separation was achieved on an Agilent Poroshell C18 column using an ...
Stacchini, Carlotta Botrè, Francesco Comunità, Fabio de la Torre, Xavier Dima, Anna Pia Ricci, Matteo Mazzarino, Monica
Published in
Journal of pharmaceutical and biomedical analysis
Analytical procedures to detect the misuse of selective androgen receptor modulators in human urine, targeting either the parent drugs and/or their main metabolites, were developed and validated. In detail, 19 target compounds belonging to 9 different chemical classes were considered: arylpropionamide (i.e., andarine (S4), ostarine (S22), S1, S6, S...
Zhou, Jun Yang, Fen Yuan, Jia Jia Bo, Yun Hai Gong, Ji Fang Shen, Lin
Published in
Journal of pharmaceutical and biomedical analysis
Sinoporphyrin sodium (DVDMS) is a new photosensitizer (PS) and it is used in photodynamic therapy (PDT) against tumor. In this paper, a simple, rapid and specific ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method for the quantitation of DVDMS in human plasma was developed. The analytes were extracted from plasma s...
Bhattacharya, Chandrali Masters, Andrea R Bach, Christine Stratford, Robert E Jr
Published in
Journal of pharmaceutical and biomedical analysis
Pharmacologic effects elicited by drugs most directly relate to their unbound concentrations. Measurement of binding in blood, plasma and target tissues are used to estimate these concentrations by determining the fraction of total concentration in a biological matrix that is not bound. In the case of attempting to estimate R- and S-bupropion conce...
Dillenburg Weiss, Thaís Luise Gössling, Gustavo Venzon Antunes, Marina Schwartsmann, Gilberto Linden, Rafael Gasparin Verza, Simone
Published in
Journal of pharmaceutical and biomedical analysis
Therapeutic drug monitoring (TDM) approaches may benefit patients treated with abiraterone acetate (AA) as drug efficacy is imprecise and important pharmacokinetic variability is known. Current methods based on the analysis of plasma present the disadvantage of the fast degradation of the analytes in the liquid sample. Dried blood spots (DBS) consi...
