Weld, Ethel D Parsons, Teresa L Gollings, Ryann McCauley, Marybeth Grinsztejn, Beatriz Landovitz, Raphael J Marzinke, Mark A
Published in
Journal of pharmaceutical and biomedical analysis
Dried blood spots (DBS) have been utilized as a blood plasma alternative for therapeutic drug monitoring and pharmacologic analysis. There are analytical and physiochemical considerations in bridging drug concentrations from plasma to DBS. Recently, the long-acting antiretroviral cabotegravir (CAB) has been approved for HIV prevention, and a co-pac...
Wang, Zhichao Du, Yuanyuan Zhang, Qiaoxuan Yan, Jun Zhan, Min Zhang, Pengwei Wan, Zemin Wang, Jianbing Huang, Xianzhang Han, Liqiao
...
Published in
Journal of pharmaceutical and biomedical analysis
Blood glucose is an important monosaccharide functioning as the main source of energy for the human body. The accurate measurement of blood glucose is crucial for the screening, diagnosis, and monitoring of diabetes and diabetes-associated diseases. To assure the reliability and traceability of blood glucose measurements, we developed a reference m...
Yu, Yang Yao, Changliang Zhang, Jianqing Bi, Qirui Wei, Wenlong Li, Zhenwei Li, Jiayuan Yao, Shuai Huang, Yong Qu, Hua
...
Published in
Journal of pharmaceutical and biomedical analysis
Aconiti Lateralis Radix Praeparata is one of the most famous traditional Chinese medicines possessing a variety of pharmacological activities on top of the toxicities. Due to the heterogeneity and non-standardization of the processing procedures, the subtypes and contents of the differential compounds between different processed products still rema...
Khajavinia, Amir Yarahmadi, Mehran El-Aneed, Anas Haddadi, Azita
Published in
Journal of pharmaceutical and biomedical analysis
Docetaxel is among the most effective chemotherapeutic agents used for the treatment of solid tumors, such as breast cancer. Targeting docetaxel to the tumor site would increase the safety and efficacy of the treatment. The focus of this work was to develop an efficient liquid chromatography tandem mass spectrometry (LC-MS/MS) method to quantify do...
Markin, Pavel A Moskaleva, Natalia E Lebedeva, Svetlana A Kozin, Sergey V Grigorevskikh, Ekaterina M Kolik, Larisa G Gudasheva, Tatyana A Appolonova, Svetlana A
Published in
Journal of pharmaceutical and biomedical analysis
Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family with diverse psychopharmacological effects including antidepressant and anxiolytic actions. However, the clinical use of BDNF is limited due to its poor pharmacokinetic properties. The development of low-molecular-weight BDNF mimetics passing through the blood-brain bar...
Fu, Xiaoqing Xu, Zhanjian Gawaz, Meinrad Lämmerhofer, Michael
Published in
Journal of pharmaceutical and biomedical analysis
3-Hydroxyfatty acids (3-OH-FAs) are formed in the hydration step during mitochondrial β-oxidation of saturated straight-chain fatty acids, which is a catabolic pathway that involves several enzymes. For an unbiased biological interpretation, an enantioselective analysis of 3-OH-FAs including their stereoisomers is necessary, which may contribute to...
Hien, Ha Minh Hien, Phan Le Hung, Tran Viet
Published in
Journal of pharmaceutical and biomedical analysis
From the seed of Aesculus hippocastanum L., a complex mixture of triterpene saponin glycosides known as aescin was isolated, purified and characterized to be an active pharmaceutical ingredient for preparing of drug products. A reversed phase high performance liquid chromatographic method with UV detection was developed for the determination of tot...
Krishna Murthy Kasa, S R Venkatanarayana, Muvvala Chennuru, Lakshmi Narayana Chandra Sekhara Rao, B Vemparala, Manohar Chaman, Abdul Fareed Talluri, M V N Kumar
Published in
Journal of pharmaceutical and biomedical analysis
The first, sensitive, and rapid chiral method was developed for enatioseperations and determination of cabotegravir and its enantiomeric impurities by using HPLC and LC-MS. Cabotegravir is an antiretroviral medication used for the treatment of HIV/AIDS approved by the food and drugs administration (FDA) in the year 2021. The cabotegravir chiral sep...
Malode, Shweta J Shanbhag, Mahesh M Kumari, Rohini Dkhar, Daphika S Chandra, Pranjal Shetti, Nagaraj P
Published in
Journal of pharmaceutical and biomedical analysis
In recent years, an increasing amount of attention has been paid to utilizing dedicated waste biomass as a sustainable, cheap, and abundant fuel and material source. There is a tremendous opportunity for maximizing energy production by applying different reliable waste biomass as a renewable, affordable, and excellent resource. As a result of renew...
Li, Wenqing Qian, Zhengming Lei, Qinggui Lian, Yunlan Zou, Yuansheng Wang, Yonghua Lan, Dongming
Published in
Journal of pharmaceutical and biomedical analysis
An ultra-rapid and eco-friendly method for the determination of loganic acid and gentiopicroside in Gentianae Macrophyllae Radix (GMR) was developed by vortex-assisted matrix solid-phase dispersion extraction (VAMSPD) and liquid chromatography with mass spectrometry (LC-MS). The optimized VAMSPD parameters are as follow: sample-dispersant (diatomac...
