Cuñarro-López, Yolanda Pintado-Recarte, Pilar Hernández-Martín, Concepción Paya-Martínez, Pilar López-Pérez, Rocío Cueto-Hernández, Ignacio Ruiz-Labarta, Javier Cano-Valderrama, Óscar Martínez-Pérez, Óscar Bravo-Arribas, Coral
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Published in
Journal of personalized medicine
During 2020, Coronavirus Disease-19 (COVID-19) incidence fluctuated in two clear waves across the spring and autumn periods. This study was designed to compare the maternal and perinatal clinical outcomes in obstetrics patients with COVID-19 between the two waves of infection in Spain. We conducted an observational, analytical, ambispective cohort ...
Chung, Chia-Min Kuo, Tzer-Min Yeh, Kun-Tu Lee, Chien-Hung Ko, Ying-Chin
Published in
Journal of personalized medicine
Areca nut (AN) was identified as carcinogenic to humans. Around 600 million people globally use AN in some form, yet no effective therapeutic drug is available to overcome AN addiction. This preclinical study examines the effects of antidepressants on AN use with animal models. We produced AN powder and dissolved it into drinking water, training 55...
Grothues, Sonja A G A Radermacher, Klaus
Published in
Journal of personalized medicine
The native femoral J-Curve is known to be a relevant determinant of knee biomechanics. Similarly, after total knee arthroplasty, the J-Curve of the femoral implant component is reported to have a high impact on knee kinematics. The shape of the native femoral J-Curve has previously been analyzed in 2D, however, the knee motion is not planar. In thi...
Wouters, Roel H P van der Graaf, Rieke Rigter, Tessel Bunnik, Eline M Ploem, M Corrette de Wert, Guido M W R Dondorp, Wybo J Cornel, Martina C Bredenoord, Annelien L
Published in
Journal of personalized medicine
Learning healthcare systems have recently emerged as a strategy to continuously use experiences and outcomes of clinical care for research purposes in precision medicine. Although it is known that learning healthcare transitions in general raise important ethical challenges, the ethical ramifications of such transitions in the specific context of p...
Henrikson, Nora B Blasi, Paula Figueroa Gray, Marlaine Tiffany, Brooks T Scrol, Aaron Ralston, James D Fullerton, Stephanie M Lim, Catherine Y Ewing, John Leppig, Kathleen A
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Published in
Journal of personalized medicine
Health benefits to relatives of people at known genetic risk for hereditary cancer syndromes is key to realizing the promise of precision medicine. We conducted a qualitative study to design a patient- and family-centered program for direct contact of relatives to recommend cascade genetic testing. We conducted two rounds of data collection using f...
Lee, Yejin Kim, Youn Jung Hyun, Hong-Keun Lee, Jae-Cheoun Lee, Zang Hee Kim, Jung-Wook
Published in
Journal of personalized medicine
Hereditary dentin defects can be categorized as a syndromic form predominantly related to osteogenesis imperfecta (OI) or isolated forms without other non-oral phenotypes. Mutations in the gene encoding dentin sialophosphoprotein (DSPP) have been identified to cause dentinogenesis imperfecta (DGI) Types II and III and dentin dysplasia (DD) Type II....
Henriksen, Tove Staines, Harry
Published in
Journal of personalized medicine
(1) Background: Subcutaneous apomorphine infusion (SCAI) is one of the three main treatment options for motor fluctuations in advanced Parkinson's disease (PD). The adherence to SCAI is generally considered to be low due to adverse events and because it is perceived as a treatment option to be used for a limited period only. We evaluated the reason...
Maunz, Andreas Benmansour, Fethallah Li, Yvonna Albrecht, Thomas Zhang, Yan-Ping Arcadu, Filippo Zheng, Yalin Madhusudhan, Savita Sahni, Jayashree
Published in
Journal of personalized medicine
To evaluate the performance of a machine-learning (ML) algorithm to detect and classify choroidal neovascularization (CNV), secondary to age-related macular degeneration (AMD) on spectral-domain optical coherence tomography (SD-OCT) images. Baseline fluorescein angiography (FA) and SD-OCT images from 1037 treatment-naive study eyes and 531 fellow e...
Neves, Janisleya Silva Ferreira Visentainer, Jeane Eliete Laguila Reis, Denise Manjurma da Silva Rocha Loures, Marco Antonio Alves, Hugo Vicentin Zacarias, Joana Maira Valentini Sell, Ana Maria
Published in
Journal of personalized medicine
HLA-B*27 is an important marker for spondyloarthritis (SpA), however, many SpA patients are HLA-B*27 negative. Thus, the aim of this study was to investigate the influence of IL17, TNF and VDR gene polymorphisms in SpA patients who were HLA-B*27 negative. This case-control study was conducted in 158 patients [102 patients with ankylosing spondyliti...
Nicolescu, Alin Codruț Bucur, Ștefana Giurcăneanu, Călin Gheucă-Solovăstru, Laura Constantin, Traian Furtunescu, Florentina Ancuța, Ioan Constantin, Maria Magdalena
Published in
Journal of personalized medicine
Background: Psoriasis is a chronic inflammatory disease characterized by an excessive hyperproliferation of keratinocytes and a combination of genetic, epigenetic, and environmental influences. The pathogenesis of psoriasis is complex and the exact mechanism remains elusive. Objectives: The study of the prevalence of psoriasis will allow the estima...
