George, Nisha S Bell, Rebecca Paredes, J J Taub, Peter J Andarawis-Puri, Nelly
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Tendon ruptures heal by forming a mechanically inferior scar. We have shown that male Murphy Roths large (MRL/MpJ) mice exhibit improved tendon healing, suggesting that they can inform biological mechanisms that lead to effective tendon healing. As sex impacts healing, we assessed the effect of sex on tendon healing in MRL/MpJ and normal healer C57...
Ismailidis, Petros Kaufmann, Mara Clauss, Martin Pagenstert, Geert Eckardt, Anke Ilchmann, Thomas Mündermann, Annegret Nüesch, Corina
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Kinematic differences between patients with osteoarthritis (OA) and control participants have been reported to be influenced by gait speed. The purpose of this study was to experimentally detect the effect of walking speed on differences in spatiotemporal parameters and kinematic trajectories between patients with hip OA and age-matched asymptomati...
Mason, Deborah Englund, Martin Watt, Fiona E
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
This overview of progress made in preventing post-traumatic osteoarthritis (PTOA) was delivered in a workshop at the Orthopaedics Research Society Annual Conference in 2019. As joint trauma is a major risk factor for OA, defining the molecular changes within the joint at the time of injury may enable the targeting of biological processes to prevent...
Iriondo, Claudia Liu, Felix Calivà, Francesco Kamat, Sarthak Majumdar, Sharmila Pedoia, Valentina
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Many studies have validated cartilage thickness as a biomarker for knee osteoarthritis (OA); however, few studies investigate beyond cross-sectional observations or comparisons across two timepoints. By characterizing the trajectory of cartilage thickness changes over 8 years in healthy individuals from the OA initiative data set, this study discov...
Zeininger, Angel Schmitt, Daniel Hughes-Oliver, Cherice Queen, Robin M
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Total ankle arthroplasty (TAA) is a common surgical approach for patients with end-stage ankle osteoarthritis (OA). However, very little is known about the path of the center of pressure (COP) of the foot, and thus important aspects of load transfer, muscle mechanical advantage, and balance, in patients before or after surgery. The objective of thi...
Kusano, Taiki Nakatani, Masashi Ishiguro, Naoki Ohno, Kinji Yamamoto, Naoki Morita, Mitsuhiro Yamada, Harumoto Uezumi, Akiyoshi Tsuchida, Kunihiro
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Heterotopic ossification (HO) is a pathological condition in which ectopic bone forms within soft tissues such as skeletal muscle. Human platelet-derived growth factor receptor α positive (PDGFRα+) cells, which were proved to be the original cells of HO were incubated in osteogenic differentiation medium with Food and Drug Administration-approved c...
Foucher, Kharma C Aydemir, Burcu Huang, Chun-Hao Horras, Megan Chmell, Samuel J
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Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Physical activity is important for physical function and pain relief in people with lower extremity osteoarthritis (OA). Unfortunately, people with OA are not as active as their peers without OA. The objective of this study was to determine whether aerobic capacity and fatigability are associated with physical activity in women with hip OA. We cond...
Van Dyck, Pieter Froeling, Martijn Heusdens, Christiaan H W Sijbers, Jan Ribbens, Annemie Billiet, Thibo
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Diffusion tensor imaging (DTI) provides information about tissue microstructure and its degree of organization by quantifying water diffusion. We aimed to monitor longitudinal changes in DTI parameters (fractional isotropy, FA; mean diffusivity, MD; axial diffusivity, AD; radial diffusivity, RD) of the anterior cruciate ligament (ACL) following pri...
Roth, Joshua D Howell, Stephen M Hull, Maury L
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Identifying and correcting varus-valgus (V-V) malalignment of the tibial component is important when balancing a kinematically aligned total knee arthroplasty (TKA). Accordingly, the primary objective was to determine whether the tibial forces or V-V laxities are more sensitive to, and thus more useful for identifying and correcting, V-V malalignme...
Goossens, Quentin Pastrav, Leonard Roosen, Jorg Mulier, Michiel Desmet, Wim Vander Sloten, Jos Denis, Kathleen
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The initial stability of cementless total hip arthroplasty (THA) implants is obtained by an interference fit that allows osseointegration for a long term secondary stability of the implant. Yet, finding the insertion endpoint that corresponds to an appropriate initial stability is currently often based on a number of subjective experiences of the o...
