ACL special issue, editors.
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
ACL special issue, editors.
Activation of canonical Wnt signaling accelerates intramembranous bone regeneration in male mice.
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Canonical Wnt signaling plays an important role in skeletal development, homeostasis, and both endochondral and intramembranous repair. While studies have demonstrated that the inhibition of Wnt signaling impairs intramembranous bone regeneration, how its activation affects intramembranous bone regeneration has been underexplored. Therefore, we sou...
Fabrication and maturation of integrated biphasic anatomic mesenchymal stromal cell-laden composite scaffolds for osteoc...
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Articular cartilage injury can lead to joint-wide erosion and the early onset of osteoarthritis. To address this, we recently developed a rapid fabrication method to produce patient-specific engineered cartilage tissues to replace an entire articular surface. Here, we extended that work by coupling a mesenchymal stromal cell-laden hydrogel (methacr...
Characterizing the transient response of knee cartilage to running: Decreases in cartilage T2 of female recreational run...
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Cartilage transmits and redistributes biomechanical loads in the knee joint during exercise. Exercise-induced loading alters cartilage hydration and is detectable using quantitative magnetic resonance imaging (MRI), where T2 relaxation time (T2 ) is influenced by cartilage collagen composition, fiber orientation, and changes in the extracellular ma...
One-year outcomes following physical therapist-led intervention for chronic hip-related groin pain: Ancillary analysis o...
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Evidence related to physical therapist-led intervention for patients with chronic hip-related groin pain (HRGP) is limited. The purpose was to assess sustainability of treatment effects for people with HRGP undergoing two physical therapist-led interventions. We completed an ancillary analysis of a pilot multicenter, randomized clinical trial. Fort...
Divergent effects of distinct perivascular cell subsets for intra-articular cell therapy in posttraumatic osteoarthritis...
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Intra-articular injection of mesenchymal stem cells has shown benefit for the treatment of osteoarthritis (OA). However, mesenchymal stem/stromal cells at the origin of these clinical results are heterogenous cell populations with limited cellular characterization. Here, two transgenic reporter mice were used to examine the differential effects of ...
Staphylococcal infection prevention using antibiotic-loaded mannitol-chitosan paste in a rabbit model of implant-associa...
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Antibiotic-loaded chitosan pastes have shown advantages in the treatment and coverage of complex musculoskeletal defects. We added mannitol, previously shown to increase antibiotic susceptibility of biofilm, to an injectable chitosan/polyethylene glycol paste for delivery of antibiotics. Ground sponges (0.85% acetic acid solution, 1% chitosan, 0% o...
Progressive loss of implant fixation in a preclinical rat model of cemented knee arthroplasty.
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Aseptic loosening of total knee arthroplasty continues to be a challenging clinical problem. The progression of the loosening process, from the initial well-fixed component, is not fully understood. In this study, loss of fixation of cemented hemiarthroplasty was explored using 9-month-old Sprague-Dawley rats with 0, 2, 6, 12, 26 week end points. M...
Measuring 3D growth plate shape: Methodology and application to cam morphology.
...Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Physeal changes corresponding to cam morphology are currently measured using two-dimensional (2D) methods. These methods are limited by definitions of the femoral neck axis and head center that are dependent on the radiographic plane of view. To address these limitations, we developed three-dimensional (3D) methods for analyzing continuous growth p...
Cartilage articulation exacerbates chondrocyte damage and death after impact injury.
Published in Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Posttraumatic osteoarthritis (PTOA) is typically initiated by momentary supraphysiologic shear and compressive forces delivered to articular cartilage during acute joint injury and develops through subsequent degradation of cartilage matrix components and tissue remodeling. PTOA affects 12% of the population who experience osteoarthritis and is att...
