Renner, Kristen E Franck, Christopher T Miller, Thomas K Queen, Robin M
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
There is limited literature that follows a population of Anterior Cruciate Ligament Reconstruction (ACLR) patients through recovery. Our aim was to examine differences in movement and loading patterns across time and between limbs over four visits during 12 months post-ACLR. We hypothesized that kinematic and kinetic data during a stop-jump would h...
Firner, Sara Willwacher, Steffen de Marées, Markus Bleuel, Judith Zaucke, Frank Brüggemann, Gert-Peter Niehoff, Anja
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
The purpose of the study was to investigate the effect of an increase in mechanical knee joint loading during running on the serum COMP level. On two different test days, 20 healthy men ran with knee orthoses for 30 min on a treadmill (v = 2.2 m/s). On day 1, the orthoses were passive, whereas on day 2 they were pneumatically driven (active) and th...
Riester, Scott M Lin, Yang Wang, Wei Cong, Lin Ali, Abdel-Moneim Mohamed Peck, Sun H Smith, Lachlan J Currier, Bradford L Clark, Michelle Huddleston, Paul
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Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Degenerative disk disease of the spine is a major cause of back pain and disability. Optimization of regenerative medical therapies for degenerative disk disease requires a deep mechanistic understanding of the factors controlling the structural integrity of spinal tissues. In this investigation, we sought to identify candidate regulatory genes con...
Beveridge, Jillian E Machan, Jason T Walsh, Edward G Kiapour, Ata M Karamchedu, N Padmini Chin, Kaitlyn E Proffen, Benedikt L Sieker, Jakob T Murray, Martha M Fleming, Braden C
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Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Our time-specific, T2 *-based regression model may allow us to estimate the structural properties of ACL repairs in vivo longitudinally. This article is protected by copyright. All rights reserved.
Farnsworth, Christopher W Schott, Eric M Benvie, Abigail M Zukoski, Jacob Kates, Stephen L Schwarz, Edward M Gill, Steven R Zuscik, Michael J Mooney, Robert A
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Obese and type 2 diabetic (T2D) patients have a 5-fold increased rate of infection following placement of an indwelling orthopaedic device. Though implant infections are associated with inflammation, periosteal reactive bone formation and osteolysis, the effect of obesity/T2D on these complicating factors has not been studied. To address this quest...
Mashiatulla, Maleeha Moran, Meghan M Chan, Deva Li, Jun Freedman, Jonathan D Snyder, Brian D Grinstaff, Mark W Plaas, Anna Sumner, Dale R
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Articular cartilage lines the load-bearing surfaces of long bones and undergoes compositional and structural degeneration during osteoarthritis progression. Contrast enhanced microcomputed tomography (μCT) is being applied to a variety of preclinical models, including the mouse, to map structural and compositional properties in 3-D. The thinness (∼...
Cone, Stephanie G Simpson, Sean G Piedrahita, Jorge A Fordham, Lynn A Spang, Jeffrey T Fisher, Matthew B
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Musculoskeletal injuries in pediatric patients are on the rise, including significant increases in anterior cruciate ligament (ACL) injuries. Previous studies have found major anatomical changes during skeletal growth in the soft tissues of the knee. Specifically, the ACL and the posterior cruciate ligament (PCL) change in their relative orientatio...
Goodheart, Jacklyn R Miller, Mark A Oest, Megan E Mann, Kenneth A
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Aseptic loosening of joint replacements remains an important clinical problem. This work explores the process and pattern of trabecular bone resorption responsible for loss of interface fixation. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:2773-2780, 2017.
Johnston, Jessica M Connizzo, Brianne K Shetye, Snehal S Robinson, Kelsey A Huegel, Julianne Rodriguez, Ashley B Sun, Mei Adams, Sheila M Birk, David E Soslowsky, Louis J
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Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Classic Ehlers-Danlos syndrome (EDS) patients suffer from connective tissue hyperelasticity, joint instability, skin hyperextensibility, tissue fragility, and poor wound healing due to heterozygous mutations in COL5a1 or COL5a2 genes. This study investigated the roles of collagen V in establishing structure and function in uninjured patellar tendon...
Alvarez-Garcia, Oscar Matsuzaki, Tokio Olmer, Merissa Masuda, Koichi Lotz, Martin K
Published in
Journal of orthopaedic research : official publication of the Orthopaedic Research Society
Aging is a main risk factor for intervertebral disc (IVD) degeneration, the main cause of low back pain. FOXO transcription factors are important regulators of tissue homeostasis and longevity. Here, we determined the expression pattern of FOXO in healthy and degenerated human IVD and the associations with IVD degeneration during mouse aging. FOXO ...
