Barretto, Tanya A Park, Eugene Telliyan, Tamar Liu, Elaine Gallagher, Denis Librach, Clifford Baker, Andrew
Published in
Journal of neurotrauma
Vascular dysfunction arising from blood-brain barrier (BBB) breakdown after traumatic brain injury (TBI) can adversely affect neuronal health and behavioral outcome. Pericytes and endothelial cells of the neurovascular unit (NVU) function collectively to maintain strict regulation of the BBB through tight junctions. Secondary injury mechanisms, suc...
McDonald, Stuart J Shultz, Sandy R Agoston, Denes V
Published in
Journal of neurotrauma
Blood-based protein biomarkers have revolutionized several fields of medicine by enabling molecular level diagnosis, as well as monitoring disease progression and treatment efficacy. Traumatic brain injury (TBI) so far has benefitted only moderately from using protein biomarkers to improve injury outcome. Because of its complexity and dynamic natur...
Vijayakumari, Anupa Ambili Parker, Drew Osmanlioglu, Yusuf Alappatt, Jacob A Whyte, John Diaz-Arrastia, Ramon Kim, Junghoon J Verma, Ragini
Published in
Journal of neurotrauma
Traumatic brain injury (TBI) is a major clinical and public health problem with few therapeutic interventions successfully translated to the clinic. Identifying imaging-based biomarkers characterizing injury severity and predicting long-term functional and cognitive outcomes in TBI patients is crucial for treatment. TBI results in white matter (WM)...
Jia, Xiaoyan Chang, Xuebin Bai, Lijun Wang, Yulin Dong, Debo Gan, Shuoqiu Wang, Shan Li, Xuan Yang, Xuefei Sun, Yinxiang
...
Published in
Journal of neurotrauma
Some patients after mild traumatic brain injury (mTBI) experience microstructural damages in the long-distance white matter (WM) connections, which disrupts the functional connectome of large-scale brain networks that support cognitive function. Patterns of WM structural damage following mTBI were well documented using diffusion tensor imaging (DTI...
Falk, Hayley Bechtold, Kathleen T Peters, Matthew E Roy, Durga Rao, Vani Lavieri, Mariel Sair, Haris Van Meter, Timothy E Korley, Frederick
Published in
Journal of neurotrauma
The lack of well-performing prognostic models for early prognostication of outcomes remains a major barrier to improving the clinical care of patients with mild traumatic brain injury (mTBI). We aimed to derive a prognostic model for predicting incomplete recovery at 1-month in emergency department (ED) patients with mTBI and a presenting Glasgow C...
Shin, Samuel S Hwang, Misun Diaz-Arrastia, Ramon Kilbaugh, Todd J
Published in
Journal of neurotrauma
Despite multiple prior pharmacological trials in traumatic brain injury (TBI), the search for an effective, safe, and practical treatment of these patients remains ongoing. Given the ease of delivery and rapid absorption into the systemic circulation, inhalational gases that have neuroprotective properties will be an invaluable resource in the clin...
Huie, J Russell Mondello, Stefania Lindsell, Christopher J Antiga, Luca Yuh, Esther L Zanier, Elisa R Masson, Serge Rosario, Bedda L Ferguson, Adam R
Published in
Journal of neurotrauma
Recent biomarker innovations hold potential for transforming diagnosis, prognostic modeling, and precision therapeutic targeting of traumatic brain injury (TBI). However, many biomarkers, including brain imaging, genomics, and proteomics, involve vast quantities of high-throughput and high-content data. Management, curation, analysis, and evidence ...
Retel Helmrich, Isabel R A Lingsma, Hester F Turgeon, Alexis F Yamal, Jose-Miguel Steyerberg, Ewout W
Published in
Journal of neurotrauma
Prognostic assessment in traumatic brain injury (TBI) is embedded deeply in clinical care. Considering the limitations of current prognostic indicators, there is increasing interest in understanding the role of new biomarkers, and in finding other prognostic indicators of long-term outcomes following TBI. New prognostic indicators may result in the...
Nielson, Jessica L Cooper, Shelly R Seabury, Seth A Luciani, Davide Fabio, Anthony Temkin, Nancy R Ferguson, Adam R
Published in
Journal of neurotrauma
Missing data is a persistent and unavoidable problem in even the most carefully designed traumatic brain injury (TBI) clinical research. Missing data patterns may result from participant dropout, non-compliance, technical issues, or even death. This review describes the types of missing data that are common in TBI research, and assesses the strengt...
Piantino, Juan Schwartz, Daniel L Luther, Madison Newgard, Craig Silbert, Lisa Raskind, Murray Pagulayan, Kathleen Kleinhans, Natalia Iliff, Jeffrey Peskind, Elaine
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Published in
Journal of neurotrauma
Impaired clearance of perivascular waste in the brain may play a critical role in morbidity after mild traumatic brain injury (mTBI). We aimed to determine the effect of mTBI on the burden of magnetic resonance imaging (MRI)-visible perivascular spaces (PVSs) in a cohort of U.S. military veterans and whether sleep modulates this effect. We also inv...
