Williams, Aaron M Dennahy, Isabel S Bhatti, Umar F Halaweish, Ihab Xiong, Ye Chang, Panpan Nikolian, Vahagn C Chtraklin, Kiril Brown, Jordana Zhang, Yanlu
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Published in
Journal of neurotrauma
Combined traumatic brain injury (TBI) and hemorrhagic shock (HS) remains a leading cause of preventable death worldwide. Mesenchymal stem cell-derived exosomes have demonstrated promise in small animal models of neurologic injury. To investigate the effects of exosome treatment in a clinically realistic large animal model, Yorkshire swine were subj...
Jalloh, Ibrahim Helmy, Adel Howe, Duncan Shannon, Richard J Grice, Peter Mason, Andrew Gallagher, Clare N Murphy, Michael Pickard, John Menon, David
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Published in
Journal of neurotrauma
Metabolic abnormalities occur after traumatic brain injury (TBI). Glucose is conventionally regarded as the major energy substrate, although lactate can also be an energy source. We compared 3-13C lactate metabolism in TBI with "normal" control brain and muscle, measuring 13C-glutamine enrichment to assess tricarboxylic acid (TCA) cycle metabolism....
Flygt, Johanna Ruscher, Karsten Norberg, Amanda Mir, Anis Gram, Hermann Clausen, Fredrik Marklund, Niklas
Published in
Journal of neurotrauma
Traumatic brain injury (TBI) commonly results in injury to the components of the white matter tracts, causing post-injury cognitive deficits. The myelin-producing oligodendrocytes (OLs) are vulnerable to TBI although may plausibly be replaced by proliferating oligodendrocyte progenitor cells (OPCs). The cytokine interleukin-1β (IL-1β) is a key medi...
Farhadi, H Francis Kukreja, Sunil Minnema, Amy Vatti, Lohith Gopinath, Meera Prevedello, Luciano Chen, Cheng Xiang, Huiyun Schwab, Jan M
Published in
Journal of neurotrauma
Variable and unpredictable spontaneous recovery can occur after acute cervical traumatic spinal cord injury (tSCI). Despite the critical clinical and interventional trial planning implications of this tSCI feature, baseline measures to predict neurologic recovery accurately are not well defined. In this study, we used data derived from 99 consecuti...
Saraswat Ohri, Sujata Mullins, Ashley Hetman, Michal Whittemore, Scott R
Published in
Journal of neurotrauma
The endoplasmic reticulum stress response (ERSR) is activated in a variety of neurodegenerative diseases and/or traumatic injuries. Subsequent restoration of ER homeostasis may contribute to improvement in the functional outcome of these diseases. We recently demonstrated improvements in hindlimb locomotion after thoracic spinal cord injury (SCI) a...
Alshareef, Ahmed Giudice, J Sebastian Forman, Jason Salzar, Robert S Panzer, Matthew B
Published in
Journal of neurotrauma
Traumatic brain injuries (TBI) are one of the least understood injuries to the body. Finite element (FE) models of the brain have been crucial for understanding concussion and for developing injury mitigation systems; however, the experimental brain deformation data currently used to validate these models are limited. The objective of this study wa...
Gordon, Evan M Scheibel, Randall S Zambrano-Vazquez, Laura Jia-Richards, Meilin May, Geoffrey J Meyer, Eric C Nelson, Steven M
Published in
Journal of neurotrauma
Traumatic brain injury (TBI) disrupts brain communication and increases risk for post-traumatic stress disorder (PTSD). However, mechanisms by which TBI-related disruption of brain communication confers PTSD risk have not been successfully elucidated in humans. This may be in part because functional MRI (fMRI), the most common technique for measuri...
Alizadeh, Mahdi Fisher, Joshua Saksena, Sona Sultan, Yusra Conklin, Chris J Middleton, Devon M Finsterbusch, Jürgen Krisa, Laura Flanders, Adam E Faro, Scott H
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Published in
Journal of neurotrauma
The aim of this study is to assess the utility and effectiveness of diffusion tensor imaging (DTI) and diffusion tensor tractography (DTT) of the entire pediatric cervical and thoracic spinal cord toward discrimination of typically developing (TD) controls and subjects with spinal cord injury (SCI). A total of 43 pediatric subjects, including 23 TD...
Kawata, Keisuke Rubin, Leah H Wesley, Leroy Lee, Jong Hyun Sim, Thomas Takahagi, Masahiro Bellamy, Al Tierney, Ryan Langford, Dianne
Published in
Journal of neurotrauma
Athletes in contact sports sustain repetitive subconcussive head impacts in a brief window, yet neurophysiological sequelae from repetitive subconcussion remain unclear. This prospective longitudinal study examined a relationship between changes in plasma Tau protein levels and subconcussive impact kinematic data in 23 Division I collegiate footbal...
Oliver, Jonathan M Jones, Margaret T Anzalone, Anthony J Kirk, K Michele Gable, David A Repshas, Justin T Johnson, Torie A Höglund, Kina Blennow, Kaj Zetterberg, Henrik
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Published in
Journal of neurotrauma
American football athletes are routinely exposed to sub-concussive impacts over the course of the season. This study sought to examine the effect of a season of American football on plasma tau, a potential marker of axonal damage. Nineteen National Collegiate Athletic Association (NCAA) football athletes underwent serial blood sampling over the cou...
