Korley, Frederick Pauls, Qi Yeatts, Sharon D Jones, Courtney Marie Cora Corbett-Valade, Emily Silbergleit, Robert Frankel, Michael Barsan, William Cahill, Nathan D Bazarian, Jeffrey J
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Published in
Journal of neurotrauma
Early treatment of moderate/severe traumatic brain injury (TBI) with progesterone does not improve clinical outcomes. This is in contrast with findings from pre-clinical studies of progesterone in TBI. To understand the reasons for the negative clinical trial, we investigated whether progesterone treatment has the desired biological effect of decre...
Lucca, Lucia F De Tanti, Antonio Cava, Francesca Romoli, Annamaria Formisano, Rita Scarponi, Federico Estraneo, Anna Frattini, Diana Tonin, Paolo Bertolino, Chiara
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Published in
Journal of neurotrauma
In this multi-center study, we provide a systematic evaluation of the clinical variability associated with paroxysmal sympathetic hyperactivity (PSH) in patients with acquired brain injury (ABI) to determine how these signs can impact outcomes. A total of 156 ABI patients with a disorder of consciousness (DoC) were admitted to neurorehabilitation s...
Osuka, Koji Ohmichi, Yusuke Ohmichi, Mika Nakura, Takahiro Iwami, Kenichiro Watanabe, Yasuo Miyachi, Shigeru
Published in
Journal of neurotrauma
Chronic subdural hematoma (CSDH) is considered an angiogenic and inflammatory disease. Chemokines attract leukocytes, and invading neutrophils and monocytes/macrophages play important roles in wound healing. However, no studies have been reported regarding changes in expression of chemokines in CSDH fluid after trepanation surgery. We randomly divi...
Kow, Chien Yew Harley, Benjamin Li, Charles Romo, Phillip Gkolia, Panagiota Lu, Kuan-Ying Bell, Catherine Jithoo, Rondhir Tee, Jin Cooper, D James
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Published in
Journal of neurotrauma
To investigate cerebral autoregulatory status in patients with severe traumatic brain injury (TBI), guidelines now suggest active manipulation of mean arterial pressure (MAP). There is a paucity of data, however, describing the effect on intracranial pressure (ICP) when MAP is raised. Consecutive patients with TBI requiring ICP monitoring were enro...
Perez Garcia, Georgina Perez, Gissel M De Gasperi, Rita Gama Sosa, Miguel A Otero-Pagan, Alena Pryor, Dylan Abutarboush, Rania Kawoos, Usmah Hof, Patrick R Cook, David G
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Published in
Journal of neurotrauma
Many military veterans who experienced blast-related traumatic brain injuries (TBI) in the conflicts in Iraq and Afghanistan currently have chronic cognitive and mental health problems including post-traumatic stress disorder (PTSD). Besides static symptoms, new symptoms may emerge or existing symptoms may worsen. TBI is also a risk factor for late...
Liraz-Zaltsman, Sigal Friedman-Levi, Yael Shabashov-Stone, Dalia Gincberg, Galit Atrakcy-Baranes, Dana Joy, Mary Teena Carmichael, S Thomas Silva, Alcino J Shohami, Esther
Published in
Journal of neurotrauma
Recently, chemokine receptor CC chemokine receptor 5 (CCR5) was found to be a negative modulator of learning and memory. Its inhibition improved outcome after stroke and traumatic brain injury (TBI). To better understand its role after TBI and establish therapeutic strategies, we investigated the effect of reduced CCR5 signaling as a neuroprotectiv...
Hergert, Danielle C Robertson-Benta, Cidney Sicard, Veronik Schwotzer, Daniela Hutchison, Kent Covey, Dan P Quinn, Davin K Sadek, Joseph R McDonald, Jacob Mayer, Andrew R
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Published in
Journal of neurotrauma
There is not a single pharmacological agent with demonstrated therapeutic efficacy for traumatic brain injury (TBI). With recent legalization efforts and the growing popularity of medical cannabis, patients with TBI will inevitably consider medical cannabis as a treatment option. Pre-clinical TBI research suggests that cannabinoids have neuroprotec...
Svedung Wettervik, Teodor Howells, Timothy Hillered, Lars Rostami, Elham Lewén, Anders Enblad, Per
Published in
Journal of neurotrauma
Current guidelines in traumatic brain injury (TBI) recommend a cerebral perfusion pressure (CPP) within the fixed interval of 60-70 mm Hg. However, the autoregulatory, optimal CPP target (CPPopt) might yield better cerebral blood flow (CBF) regulation. In this study, we investigated fixed versus autoregulatory CPP targets in relation to cerebral en...
Nguyen, Tyler Al-Juboori, Mohammed Haider Walerstein, Jakub Xiong, Wenhui Jin, Xiaoming
Published in
Journal of neurotrauma
Although mild traumatic brain injury (mTBI) accounts for the majority of TBI patients, the effects and cellular and molecular mechanisms of mTBI on cortical neural circuits are still not well understood. Given the transient and non-specific functional deficits after mTBI, it is important to understand whether mTBI causes functional deficits of the ...
Caliendo, Eric T Kim, Nayoung Edasery, David Askin, Gulce Nowak, Sophie Gerber, Linda M Baum, Katherine T Blackwell, Laura S Koterba, Christine H Hoskinson, Kristen R
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Published in
Journal of neurotrauma
Traumatic brain injury (TBI) is a major cause of morbidity and mortality in children; survivors experience long-term cognitive and motor deficits. To date, studies predicting outcome following pediatric TBI have primarily focused on acute behavioral responses and proxy measures of injury severity; unsurprisingly, these measures explain very little ...
