Aarabi, Bizhan Akhtar-Danesh, Noori Simard, J Marc M.D., Ph.D Chryssikos, Timothy Shanmuganathan, Kathirkamanthan Olexa, Joshua Sansur, Charles Crandall, Kenneth Wessell, Aaron Cannarsa, Gregory
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Published in
Journal of neurotrauma
The therapeutic significance of timing of decompression in acute traumatic central cord syndrome (ATCCS) due to spinal stenosis remains unsettled. We retrospectively examined a homogenous cohort of patients with ATCCS and MRI evidence of post-treatment spinal cord decompression to determine whether timing of decompression played a significant role ...
Meier, Timothy B España, Lezlie Y Kirk, Alexander J Nader, Amy M Powell, Jennifer E Nelson, Lindsay D Mayer, Andrew R Brett, Benjamin L
Published in
Journal of neurotrauma
There is concern that previous concussion and contact-sport exposure may have negative effects on brain structure and function. Accurately quantifying previous concussion is complicated by the fact that multiple definitions exist, with recent definitions allowing for diagnosis based on the presence of symptoms alone (Concussion in Sport Group crite...
Zusman, Benjamin E Kochanek, Patrick M Bell, Michael J Adelson, P David Wisniewski, Stephen R Au, Alicia K Clark, Robert S B Bayır, Hülya Janesko-Feldman, Keri Jha, Ruchira M
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Published in
Journal of neurotrauma
Sulfonylurea receptor-1 (SUR1) is recognized increasingly as a key contributor to cerebral edema, hemorrhage progression, and possibly neuronal death in multiple forms of acute brain injury. SUR1 inhibition may be protective and is actively undergoing evaluation in Phase-2/3 trials of traumatic brain injury (TBI) and stroke. In adult TBI, SUR1 expr...
Wang, Qi Mergia, Evanthia Koesling, Doris Mittmann, Thomas
Published in
Journal of neurotrauma
Traumatic brain injury (TBI) often induces structural damage, disruption of the blood-brain barrier (BBB), neurodegeneration, and dysfunctions of surviving neuronal networks. Nitric oxide (NO) signaling has been suggested to affect brain functions after TBI. The NO exhibits most of its biological effects by activation of the primary targets-guanyly...
Kunzmann, Kevin Wernisch, Lorenz Richardson, Sylvia Steyerberg, Ewout W Lingsma, Hester Ercole, Ari Maas, Andrew I R Menon, David Wilson, Lindsay
Published in
Journal of neurotrauma
Loss to follow-up and missing outcomes data are important issues for longitudinal observational studies and clinical trials in traumatic brain injury. One popular solution to missing 6-month outcomes has been to use the last observation carried forward (LOCF). The purpose of the current study was to compare the performance of model-based single-imp...
O'Reilly, Micaela Mironets, Eugene Saltos, Tatiana Crowther, Kallon Collyer, Eileen Bethea, John Tom, Veronica J
Published in
Journal of neurotrauma
Following a severe, high-level spinal cord injury (SCI), plasticity to intraspinal circuits below-injury results in heightened spinal sympathetic reflex activity and detrimentally impacts peripheral organ systems. Such sympathetic hyperreflexia is immediately apparent as an episode of autonomic dysreflexia (AD), a life-threatening condition charact...
DiGuglielmo, Daniella M Milef, Gabriella M Moore, Justin B Kelley, Mireille E Powers, Alexander K Stitzel, Joel D Urban, Jillian E
Published in
Journal of neurotrauma
With the concern of concussion risk and repetitive head impacts in youth football, organizations have adopted rules that limit contact during practice. However, rule changes are not ubiquitous among organizations and are challenging to monitor and enforce. Ultimately, football practice activities are determined by coaches, but it is unknown whether...
Bartnik-Olson, Brenda Holshouser, Barbara Ghosh, Nirmalya Oyoyo, Udochukwu E Nichols, Joy G Pivonka-Jones, Jamie Tong, Karen Ashwal, Stephen
Published in
Journal of neurotrauma
This study is unique in that it examines the evolution of white matter injury very early and at 12 months post-injury in pediatric patients following traumatic brain injury (TBI). Diffusion tensor imaging (DTI) was acquired at two time-points: acutely at 6-17 days and 12 months following a complicated mild (cMild)/moderate (mod) or severe TBI. Regi...
Khaing, Zin Z Cates, Lindsay N Dewees, Dane M Hyde, Jeffrey E Gaing, Ashley Birjandian, Zeinab Hofstetter, Christoph P
Published in
Journal of neurotrauma
Various surgical strategies have been developed to alleviate elevated intraspinal pressure (ISP) following acute traumatic spinal cord injury (tSCI). Surgical decompression of either the dural (durotomy) or the dural and pial (myelotomy) lining of the spinal cord has been proposed. However, a direct comparison of these two strategies is lacking. He...
O'Brien, William T Symons, Georgia F Bain, Jesse Major, Brendan P Costello, Daniel M Sun, Mujun Kimpton, Joshua S Chen, Zhibin Brady, Rhys D Mychasiuk, Richelle
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Published in
Journal of neurotrauma
It is increasingly reported that a history of concussion may be associated with chronic deleterious consequences. While the pathophysiology that contributes to these consequences is not well understood, neuroinflammation is postulated to be critical. Activation of multiprotein complexes termed inflammasomes, a key component of this inflammatory res...
