Kiasalari, Zahra Afshin-Majd, Siamak Baluchnejadmojarad, Tourandokht Azadi-Ahmadabadi, Ensie Fakour, Marzieh Ghasemi-Tarie, Reihaneh Jalalzade-Ogvar, Shahram Khodashenas, Vahid Tashakori-Miyanroudi, Mahsa Roghani, Mehrdad
...
Published in
Journal of molecular neuroscience : MN
Multiple sclerosis (MS) is known as a chronic neuroinflammatory disorder typified by an immune-mediated demyelination process with ensuing axonal damage and loss. Sinomenine is a natural alkaloid with different therapeutic benefits, including anti-inflammatory and immunosuppressive activities. In this study, possible beneficial effects of sinomenin...
Badrlou, Elham Ghafouri-Fard, Soudeh Omrani, Mir Davood Neishabouri, Seyedeh Morvarid Arsang-Jang, Shahram Taheri, Mohammad Pouresmaeili, Farkhondeh
Published in
Journal of molecular neuroscience : MN
Long non-coding RNAs (lncRNAs) play a decisive role in the development of the central nervous system and modulation, differentiation, and function of neurons. Thus, any abnormal pattern of expression of these transcripts might alter normal development leading to neuropsychiatric disorders. In this regard, transcripts of brain-derived neurotrophic f...
Wang, Feng Wang, Lu Sui, Guanghong Yang, Caixia Guo, Mengtian Xiong, Xiangyang Chen, Zheng Lei, Ping
Published in
Journal of molecular neuroscience : MN
Inflammation contributes to mitochondrial dysfunction and neuronal apoptosis. The aim of this study was to determine whether insulin-like growth factor-1 (IGF-1) alleviates mitochondrial apoptosis in lipopolysaccharide (LPS)-treated PC-12 cells, and to further explore the mechanism involved. Prepared PC-12 cells were treated with IGF-1, Mdivi-1 (DR...
Chaji, Daniel Venkatesh, Varun S Shirao, Tomoaki Day, Darren J Ellenbroek, Bart A
Published in
Journal of molecular neuroscience : MN
Dysregulation of the serotonergic system has been reported to have a significant role in several neurological disorders including depression, autism and substance abuse disorders. Changes in the expression of the serotonin transporter (SERT) through polymorphisms in the regulatory regions of the SERT gene have been associated, but not yet been conc...
Kong, Ying Li, Shulin Zhang, Miao Xu, Wenting Chen, Qiuxin Zheng, Lihong Liu, Peng Zou, Wei
Published in
Journal of molecular neuroscience : MN
Baihui-penetrating-Qubin acupuncture is frequently used to treat intracerebral hemorrhage (ICH) in China. Acupuncture affects multiple microRNAs in diseases. MicroRNA-23a-3p (miR-23a-3p) has been demonstrated to be up-regulated in ICH patients. Herein, the effect of Baihui-penetrating-Qubin acupuncture on miR-23a-3p expression after ICH and the rol...
Zhang, Guiliang Wu, Jiahui Huang, Chunhui Cheng, Jiehong Su, Zhiyang Zhu, Zeyu Yang, Xifei Guo, Baojian Wu, Liangmiao Zhang, Zaijun
...
Published in
Journal of molecular neuroscience : MN
T-006, a small-molecule compound derived from tetramethylpyrazine (TMP), has potential for the treatment of neurological diseases. In order to investigate the effect of T-006 prophylactic treatment on an Alzheimer's disease (AD) model and identify the target of T-006, we intragastrically administered T-006 (3 mg/kg) to Alzheimer's disease (AD) tran...
D'Amico, Agata Grazia Maugeri, Grazia Musumeci, Giuseppe Reglodi, Dora D'Agata, Velia
Published in
Journal of molecular neuroscience : MN
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a peptide involved in physio-pathological processes of the eye. It exerts multiple effects directly through activation of its related receptors and indirectly through increases in the synthesis of activity-dependent neuroprotective protein (ADNP). To study the role of ADNP and protect ag...
Tancheva, Lyubka Lazarova, Maria Saso, Luciano Kalfin, Reni Stefanova, Miroslava Uzunova, Diamara Atanasov, Atanas G
Published in
Journal of molecular neuroscience : MN
Previous evidence has shown a link between neurodegenerative diseases, including Parkinson's disease (PD), and melatonin. The data in the literature about the impact of the hormone under different experimental PD conditions are quite controversial, and its effect on memory impairment in the disease is very poorly explored. The current research was ...
Zhang, Wang Wang, Haiyang Liu, Binchao Jiang, Miaomiao Gu, Yifei Yan, Shi Han, Xian Hou, Alicia Y Tang, Chongyang Jiang, Zhenfeng
...
Published in
Journal of molecular neuroscience : MN
Hippocampal sclerosis (HS) is one of the most prevalent pathological types of temporal lobe epilepsy (TLE), and it significantly affects patient prognoses. The methylation of DNA plays an important role in the development of epilepsy. However, few studies have focused on HS subtypes to determine DNA methylation profiles in TLE. This study aimed to ...
Guo, Qi Wei Si, Yan Jun Shen, Yi Lin Chen, Xu Yang, Mei Fang, Ding Zhi Lin, Jia
Published in
Journal of molecular neuroscience : MN
The association of apolipoprotein AIV (APOA4) with depression or plasma levels of lipids and glucose has been inconsistently reported. However, interplays between APOA4 and depression on the levels have not been explored yet. The present study aimed to investigate plasma levels of APOA4, lipids, and glucose in adolescents with different genotypes o...
