Han, Liang Xu, Yanhao Shi, Yuxiu
Published in
Journal of molecular neuroscience : MN
Apoptosis of hippocampal neurons is one of the mechanisms of hippocampal atrophy in posttraumatic stress disorder (PTSD), and it is also an important cause of memory impairment in PTSD patients. Endoplasmic reticulum stress (ERS) mediated by activated transcription factor 6α (ATF6α)/site 1 protease (S1P)/S2P is involved in cell apoptosis, but it is...
Boucher, Melissa N Aktar, Mahafuza Braas, Karen M May, Victor Hammack, Sayamwong E
Published in
Journal of molecular neuroscience : MN
Anxiety disorders are among the most common psychiatric disorders, and understanding the underlying neurocircuitry of anxiety- and stress-related behaviors may be important for treatment. The bed nucleus of the stria terminalis (BNST) has been studied for its role in many stress-related pathologies, such as anxiety, pain, depression, and addiction....
Davarinejad, Omran Najafi, Sajad Zhaleh, Hossein Golmohammadi, Farzaneh Radmehr, Farnaz Alikhani, Mostafa Moghadam, Reza Heidari Rahmati, Yazdan
Published in
Journal of molecular neuroscience : MN
Schizophrenia is a severe chronic debilitating disorder with millions of affected individuals. Diagnosis is based on clinical presentations, which are made when the progressive disease has appeared. Early diagnosis may help improve the clinical outcomes and response to treatments. Lack of a reliable molecular diagnostic invokes the identification o...
Badrlou, Elham Ghafouri-Fard, Soudeh Omrani, Mir Davood Neishabouri, Seyedeh Morvarid Arsang-Jang, Shahram Taheri, Mohammad Pouresmaeili, Farkhondeh
Published in
Journal of molecular neuroscience : MN
Long non-coding RNAs (lncRNAs) play a decisive role in the development of the central nervous system and modulation, differentiation, and function of neurons. Thus, any abnormal pattern of expression of these transcripts might alter normal development leading to neuropsychiatric disorders. In this regard, transcripts of brain-derived neurotrophic f...
Santhoshkumar, Rashmi Preethish-Kumar, Veeramani Mangalaparthi, Kiran K Unni, Sruthi Padmanabhan, Balasundaram T S, Keshava Prasad Nongthomba, Upendra Atchayaram, Nalini Narayanappa, Gayathri
Published in
Journal of molecular neuroscience : MN
FHL1-related myopathies are rare X-linked dominant myopathies. Though clinically classified into several subgroups, spinal and scapuloperoneal muscle involvement are common to all. In this study, we identified c.449G > A, p.C150Y mutation by clinical exome sequencing in two patients from same family (son and mother) of Indian origin who presented w...
Deepha, Sekar Govindaraj, Periyasamy Sankaran, Bindu Parayil Chiplunkar, Shwetha Kashinkunti, Chetan Nunia, Vandana Nagappa, Madhu Sinha, Sanjib Khanna, Tripti Thangaraj, Kumarasamy
...
Published in
Journal of molecular neuroscience : MN
Polymerase γ catalytic subunit (POLG), a nuclear gene, encodes the enzyme responsible for mitochondrial DNA (mtDNA) replication. POLG mutations are a major cause of inherited mitochondrial diseases. They present with varied phenotypes, age of onset, and severity. Reports on POLG mutations from India are limited. Hence, this study aimed to describe ...
Khorrami, Mehdi Khorram, Erfan Yaghini, Omid Rezaei, Mojgan Hejazifar, Arash Iravani, Omid Yazdani, Vida Riahinezhad, Maryam Kheirollahi, Majid
Published in
Journal of molecular neuroscience : MN
Vanishing white matter disease (VWM) is a rare autosomal recessive leukodystrophy caused by a mutation in any of the five gene encoding subunits of the translation initiation factors eIF2B1 to eIF2B5. Whole-exome sequencing was performed on a 7-year-old boy with prenatal symptoms, including intrauterine-growth retardation, decreased movements, and ...
Chaji, Daniel Venkatesh, Varun S Shirao, Tomoaki Day, Darren J Ellenbroek, Bart A
Published in
Journal of molecular neuroscience : MN
Dysregulation of the serotonergic system has been reported to have a significant role in several neurological disorders including depression, autism and substance abuse disorders. Changes in the expression of the serotonin transporter (SERT) through polymorphisms in the regulatory regions of the SERT gene have been associated, but not yet been conc...
Wang, Man Han, Yuechen Wang, Xue Liang, Shuo Bo, Chuan Zhang, Zhenbiao Wang, Mingming Xu, Lei Zhang, Daogong Liu, Wenwen
...
Published in
Journal of molecular neuroscience : MN
Deprivation of acoustic input during a critical period leads to abnormal auditory development in humans. The molecular basis underlying the susceptibility of auditory cortex to loss of afferent input remains largely unknown. The transcription factor early growth response-1 (EGR-1) expression in the visual cortex has been shown to be crucial in the ...
Hamoudi, Wajeha von Lendenfeld, Felix Kartawy, Maryam Mencer, Shira Suloh, Huda Khaliulin, Igor Amal, Haitham
Published in
Journal of molecular neuroscience : MN
Nitric oxide (NO) is a multifunctional neurotransmitter that plays a major role in neuronal and synaptic functions. S-nitrosylation (SNO), the NO-mediated protein posttransitional modification (PTM), is known to regulate physiological and pathological processes in the brain. However, the physiological role in different neuroanatomical brain regions...
