Qian, Ping Wang, Shan Zhang, Ting Wu, Jianxin
Published in
Journal of molecular neuroscience : MN
Protein acetylation, which is dynamically maintained by histone acetyltransferases (HATs) and deacetylases (HDACs), might play essential roles in hippocampal exercise physiology. However, whether HATs/HDACs are imbalanced during the recovery phase following acute exercise has not been determined. Groups of exercised mice with different recovery per...
Sudershan, Amrit Bhagat, Meenakshi Singh, Kuljeet Pushap, Agar Chander Kumar, Hardeep Kumar, Parvinder
Published in
Journal of molecular neuroscience : MN
With a feature of complex pathogenic mechanisms, migraine is a well-known common neurovascular disorder. Multiple genes are responsible for hindering the susceptibility of pain threshold one of which is the eNOS gene and its variants. Multiple independent observational studies with case-control design produced conflicting findings, which can be att...
Sudershan, Amrit Pushap, Agar Chander Kumar, Hardeep Kumar, Parvinder
Published in
Journal of molecular neuroscience : MN
Many homeostatic genes are thought to play a role in the susceptibility to migraine, making it a highly complex neurovascular disease. In this meta-analysis, our primary objective was to evaluate whether or not MTHFR variants (such as C677T and A1289C) and ACE I/D were associated with an increased risk of migraine. Using a PRISMA-based systematic l...
Kruglyakov, Daniel Ojha, Shashank Kumar Kartawy, Maryam Tripathi, Manish Kumar Hamoudi, Wajeha Bazbaz, Wisam Khaliulin, Igor Amal, Haitham
Published in
Journal of molecular neuroscience : MN
Glioblastoma multiforme (GBM) is a prevalent and aggressive primary brain tumor, presenting substantial treatment challenges and high relapse rates. GBM is characterized by alterations in molecular signaling and enzyme expression within malignant cells. This tumor exhibits elevated nitric oxide (NO.) levels. NO. is a crucial signaling molecule invo...
Ye, Jiabei Shan, Yudong Zhou, Xiaohong Tian, Tian Gao, Weijuan
Published in
Journal of molecular neuroscience : MN
Circular RNAs (circRNAs) are abundantly and stably expressed in the brain of mammals and humans. Some circRNAs are implicated in ischemic stroke. Therefore, we aimed to detect how circRNAs change in the key penumbra area during cerebral ischemia-reperfusion (CI/R) injury. Rats were subjected to transient middle cerebral artery occlusion (tMCAO), du...
Shao, Kaiquan Wang, Zipeng Fan, Xinyu Sun, Ruiao Tang, Chuanxi
Published in
Journal of molecular neuroscience : MN
Infiltration of CD4 + T cells was found in brain tissue samples from PD patients, suggesting their involvement in developing central nervous system (CNS) disease. The idea of the gut-brain axis further corroborates intestinal T cells' activation as the central immune response initiation. However, the specific factors and molecular pathways regulati...
Chen, Xiao Xu, Ying Wang, Maode Ren, Chunying
Published in
Journal of molecular neuroscience : MN
Pyroptosis, an orchestrated cellular death pathway, has gained attention due to its role in the pathophysiology and evolution of numerous malignancies. Despite this, no robust quantitative measure of pyroptosis activity in lower-grade glioma (LGG) exists currently. We scrutinized the transcriptomic data of LGG specimens acquired from TCGA and CGGA ...
Mehra, Sweety Ahsan, Aitizaz Ul Sharma, Madhu Budhwar, Muskan Chopra, Mani
Published in
Journal of molecular neuroscience : MN
Autism is a neurodevelopmental condition, and it's associated pathophysiology, viz., oxidative stress and altered cellular homeostasis, has been extensively intertwined with behavioral impairments. Therefore, targeting oxidative stress and redox cellular homeostasis could be beneficial in relieving autistic-like symptoms. For this purpose, we exami...
Wang, Jun Zhang, Nan Liu, Hong-Zheng Wang, Jin-Liang Zhang, Yong-Bo Su, Dong-Dong Miao, Jun
Published in
Journal of molecular neuroscience : MN
Neuropathic pain is a chronic pain caused by direct damage to the peripheral or central nervous system, characterized by hyperalgesia, allodynia, and spontaneous pain. Hydrogen sulfide (H2S) therapy has been applied for neuropathic pain treatment, although the underlying mechanisms remain unknown. In this study, we sought to ascertain whether H2S t...
Cao, Lanxiao Gu, Luyan Pu, Jiali Lv, Dayao Tian, Jun Yin, Xinzhen Gao, Ting Song, Zhe Lu, Jinyu Zhao, Gaohua
...
Published in
Journal of molecular neuroscience : MN
Genetic factors play a major role in essential tremor (ET) pathogenesis. This study aimed to assess variant burden in ET-associated genes in a relatively large Chinese population cohort. We genotyped 27 single nucleotide polymorphisms (SNPs) previously reported to be associated with ET by multiplex PCR amplicon sequencing assay in 488 familial and ...
