Paravati, R De Mello, N Onyido, E K Francis, L W Brüsehafer, K Younas, K Spencer-Harty, S Conlan, R S Gonzalez, D Margarit, Lavinia
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Published in
Journal of molecular medicine (Berlin, Germany)
Endometrial receptivity is mediated by adhesion molecules at the endometrium-trophoblast interface where osteopontin (OPN) and CD44 form a protein complex that plays an important role in embryo recognition. Here, we undertook a prospective study investigating the expression and regulation of OPN and CD44 in 50 fertile and 31 infertile ovulatory pol...
Li, Bin Li, Kuokuo Tian, Di Zhou, Qiao Xie, Yali Fang, Zhenghuan Wang, Xiaomeng Luo, Tengfei Wang, Zheng Zhang, Yi
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Published in
Journal of molecular medicine (Berlin, Germany)
Epidemiological studies have shown an increased prevalence of cancer in some patients with neurodevelopmental disorder (NDD); however, the genetic mechanisms regarding how cancer-related genes (CRGs) contribute to NDD remain unclear. We performed bioinformatic analyses on 219 CRGs from OMIM and de novo mutations (DNMs) from 16,498 patients with dif...
Lambert, Vincent Hansen, Sylvain Schoumacher, Matthieu Lecomte, Julie Leenders, Justine Hubert, Pascale Herfs, Michael Blacher, Silvia Carnet, Oriane Yip, Cassandre
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Published in
Journal of molecular medicine (Berlin, Germany)
Neovascular age-related macular degeneration (nAMD) is the leading cause of blindness in aging populations. Here, we applied metabolomics to human sera of patients with nAMD during an active (exudative) phase of the pathology and found higher lactate levels and a shift in the lipoprotein profile (increased VLDL-LDL/HDL ratio). Similar metabolomics ...
Chen, Yueying Shen, Jun
Published in
Journal of molecular medicine (Berlin, Germany)
Mucosal immunity has crucial roles in human diseases such as respiratory tract infection, inflammatory bowel diseases (IBD), and colorectal cancer (CRC). Recent studies suggest that the mononuclear phagocyte system, cancer cells, bacteria, and viruses induce the mucosal immune reaction by various pathways, and can be major factors in the pathogenes...
Araki, Kota Kinoshita, Rie Tomonobu, Nahoko Gohara, Yuma Tomida, Shuta Takahashi, Yuta Senoo, Satoru Taniguchi, Akihiko Itano, Junko Yamamoto, Ken-Ichi
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Published in
Journal of molecular medicine (Berlin, Germany)
In patients with interstitial pneumonia, pulmonary fibrosis is an irreversible condition that can cause respiratory failure. Novel treatments for pulmonary fibrosis are necessary. Inflammation is thought to activate lung fibroblasts, resulting in pulmonary fibrosis. Of the known inflammatory molecules, we have focused on S100A8/A9 from the onset of...
de Carvalho Porta, Lucas Fadel, Valmir D'Arc Campeiro, Joana Oliveira, Eduardo Brandt Godinho, Rosely Oliveira Hayashi, Mirian Akemi Furuie
Published in
Journal of molecular medicine (Berlin, Germany)
Crotamine is a polypeptide isolated from the venom of a South American rattlesnake. Among the properties and biological activities of crotamine, the most extraordinary is its ability to enter cells with unique selective affinity and cytotoxic activity against actively proliferating cells, such as tumor cells. This peptide is also a cargo carrier, a...
Liu, Li Tian, Zhen Zhang, Yalin Liu, Peijun Xin, Zhiqian Zhao, Yong Li, Yifan Miao, Shan Shi, Junling Chen, Zhinan
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Published in
Journal of molecular medicine (Berlin, Germany)
Autophagy is a conserved self-degradation system closely related to cancer progression. Small molecule inhibitors of autophagy have proven to be efficient tools in cancer therapy and are in high demand. Here we report the discovery of two compounds (LZ02/01) capable of suppressing cancer cell proliferation via inhibiting autophagy flux and promotin...
Belgorosky, Denise Girouard, Julie Langle, Yanina Veronica Hamelin-Morrissete, Jovane Marino, Lina Agüero, Eduardo Imanol Malagrino, Héctor Reyes-Moreno, Carlos Eiján, Ana María
Published in
Journal of molecular medicine (Berlin, Germany)
The expression of inducible nitric oxide (NO) synthase (iNOS) in human bladder cancer (BC) is a poor prognostic factor associated with invasion and tumor recurrence. Here, we evaluated the relevance of iNOS expression in BC progression and in cancer stem cell (CSC) maintenance in a murine BC model. Also, iNOS expression and CSC markers were analyze...
Kretzschmar, Kai
Published in
Journal of molecular medicine (Berlin, Germany)
Organoid technology has rapidly transformed basic biomedical research and contributed to significant discoveries in the last decade. With the application of protocols to generate organoids from cancer tissue, organoid technology has opened up new opportunities for cancer research and therapy. Using organoid cultures derived from healthy tissues, di...
Andreucci, Elena Peppicelli, Silvia Ruzzolini, Jessica Bianchini, Francesca Biagioni, Alessio Papucci, Laura Magnelli, Lucia Mazzanti, Benedetta Stecca, Barbara Calorini, Lido
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Published in
Journal of molecular medicine (Berlin, Germany)
Acidosis characterizes the microenvironment of most solid tumors and is considered a new hallmark of cancer. It is mainly caused by both "aerobic" and "anaerobic" glycolysis of differently adapted cancer cells, with the final product lactic acid being responsible of the extracellular acidification. Many evidences underline the role of extracellular...
