Vega, Salvador Castaneda Leiss, Veronika Piekorz, Roland Calaminus, Carsten Pexa, Katja Vuozzo, Marta Schmid, Andreas M Devanathan, Vasudharani Kesenheimer, Christian Pichler, Bernd J
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Published in
Journal of molecular medicine (Berlin, Germany)
Pertussis toxin (PTX) is a potent virulence factor in patients suffering from whooping cough, but in its detoxified version, it is applied for vaccination. It is thought to contribute to the pathology of the disease including various CNS malfunctions. Based on its enzymatic activity, PTX disrupts GPCR-dependent signaling by modifying the α-subunit ...
Chen, Kai Sun, Zhongjie
Published in
Journal of molecular medicine (Berlin, Germany)
Klotho is an anti-aging gene that shortens the life span when disrupted and extends the lifespan when overexpressed. This study investigated whether autophagy plays a role in Klotho gene deficiency-induced arterial stiffening and hypertension. Klotho mutant heterozygous (KL+/-) mice and age- and sex-matched wild-type (WT) mice were used. Arteries w...
Gajjala, Prathibha R Bruck, Heike Noels, Heidi Heinze, Georg Ceccarelli, Francesco Kribben, Andreas Saez-Rodriguez, Julio Marx, Nikolaus Zidek, Walter Jankowski, Joachim
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Published in
Journal of molecular medicine (Berlin, Germany)
Chronic kidney disease (CKD) may progress to end-stage renal disease (ESRD) at different pace. Early markers of disease progression could facilitate and improve patient management. However, conventional blood and urine chemistry have proven unable to predict the progression of disease at early stages. Therefore, we performed untargeted plasma pepti...
Ma, Ke Liu, Ping Al-Maghout, Tamer Sukkar, Basma Cao, Hang Voelkl, Jakob Alesutan, Ioana Pieske, Burkert Lang, Florian
Published in
Journal of molecular medicine (Berlin, Germany)
Compromised renal phosphate elimination in chronic kidney disease (CKD) leads to hyperphosphatemia, which in turn triggers osteo-/chondrogenic signaling in vascular smooth muscle cells (VSMCs) and vascular calcification. Osteo-/chondrogenic transdifferentiation of VSMCs leads to upregulation of the transcription factors MSX2, CBFA1, and SOX9 as wel...
Tarasenko, Tatyana N Jestin, Maxim Matsumoto, Shingo Saito, Keita Hwang, Sean Gavrilova, Oksana Trivedi, Niraj Zerfas, Patricia M Barca, Emanuele DiMauro, Salvatore
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Published in
Journal of molecular medicine (Berlin, Germany)
During infection, hepatocytes must undergo a reprioritization of metabolism, termed metabolic reprogramming. Hepatic metabolic reprogramming in response to infection begins within hours of infection, suggesting a mechanism closely linked to pathogen recognition. Following injection with polyinosinic:polycytidylic acid, a mimic of viral infection, a...
Martínez, Fernando Cifuentes, Manuel Tapia, Juan Carlos Nualart, Francisco
Published in
Journal of molecular medicine (Berlin, Germany)
Our data proposes that glucose is transferred directly to the cerebrospinal fluid (CSF) of the hypothalamic ventricular cavity through a rapid "fast-track-type mechanism" that would efficiently stimulate the glucosensing areas. This mechanism would occur at the level of the median eminence (ME), a periventricular hypothalamic zone with no blood-bra...
Cao, Xiaoyu Lu, Yanxin Liu, Yang Zhou, Yiqiang Song, Hua Zhang, Wei Davis, Dionne Cui, Jing Hao, Shuyu Jung, Jinkyu
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Published in
Journal of molecular medicine (Berlin, Germany)
Chordoma, a malignant bone cancer, is highly resistant to conventional therapeutic approaches; this greatly limits radio- and chemotherapeutic options and disease management. In the present study, we investigated three patient-derived chordoma cell lines to elucidate the molecular mechanism of resistance to therapeutics. An in vitro high-throughput...
Chiozzini, Chiara Olivetta, Eleonora Sanchez, Massimo Arenaccio, Claudia Ferrantelli, Flavia Leone, Patrizia Federico, Maurizio
Published in
Journal of molecular medicine (Berlin, Germany)
Intrinsic genetic instability of tumor cells leads to continuous production of mutated proteins referred to as tumor-specific neoantigens. Generally, they are recognized as nonself products by the host immune system. However, an effective adaptive response clearing neoantigen-expressing cells is lost in tumor diseases. Most advanced therapeutic str...
Simão, André L Afonso, Marta B Rodrigues, Pedro M Gama-Carvalho, Margarida Machado, Mariana V Cortez-Pinto, Helena Rodrigues, Cecília M P Castro, Rui E
Published in
Journal of molecular medicine (Berlin, Germany)
Non-alcoholic fatty liver disease (NAFLD) pathogenesis associates with intramyocellular lipid deposition and mitochondrial dysfunction. microRNAs (miRs), including pro-apoptotic miR-34a, are modulated during disease progression in liver tissue and plasma. We aimed to investigate the functional role of the miR-34a/SIRT1:AMP-activated protein kinase ...
Fischer, Ulrike Backes, Christina Fehlmann, Tobias Galata, Valentina Keller, Andreas Meese, Eckart
Published in
Journal of molecular medicine (Berlin, Germany)
Gene amplification is an evolutionarily well-conserved and highly efficient mechanism to increase the amount of specific proteins. In humans, gene amplification is a hallmark of cancer and has recently been found during stem cell differentiation. Amplifications in stem cells are restricted to specific tissue areas and time windows, rendering their ...
