Jangani, Maryam Vuononvirta, Juho Yamani, Lamya Ward, Eleanor Capasso, Melania Nadkarni, Suchita Balkwill, Frances Marelli-Berg, Federica
Published in
Journal of leukocyte biology
Monocyte migration to the sites of inflammation and maturation into macrophages are key steps for their immune effector function. Here, we show that mechanistic target of rapamycin complex 2 (mTORC2)-dependent Akt activation is instrumental for metabolic reprogramming at the early stages of macrophage-mediated immunity. Despite an increased product...
Li, Jiao Shen, Zhen Wang, Zheng Chao, Hongying Xu, Yi Zeng, Zhao Bian, Xiaosen Zhang, Jun Pan, Jinlan Miao, Weiwei
...
Published in
Journal of leukocyte biology
ETO2 is a nuclear co-repressor, which plays a critical role in the regulation of the cell cycle, self-renewal capacity, and differentiation of hematopoietic progenitor cells. We identified novel fusion transcripts involving ETO2 and CTCF by RNA-seq in a multiple relapsed AML case. The CTCF-ETO2 and ETO2-CTCF chimeric genes were validated by RT-PCR ...
Zhang, Duobin Pan, Ning Jiang, Chuan Hao, Maolin
Published in
Journal of leukocyte biology
Ischemic stroke (IS) can cause disability and death, and microglia as the immune component of the CNS can release inflammatory factors and participate in blood-brain barrier (BBB) dysfunction. This study aimed to investigate the effects of long noncoding RNA (lncRNA) SNHG8 on microglia activation and BBB permeability in IS. A rat model of permanent...
Mo, Siwei Liu, Xiaoqian Zhang, Kehong Wang, Wenfei Cai, Yi Ouyang, Qi Zhu, Chuanzhi Lin, Dachuan Wan, Haoqiang Li, Dechang
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Published in
Journal of leukocyte biology
Tuberculosis (TB), an infectious bacterial disease caused by Mycobacterium tuberculosis (Mtb), is a major cause of death worldwide. Multidrug-resistant TB remains a public health crisis and thus novel effective treatments, such as host-directed therapies (HDTs), are urgently required to overcome the challenges of TB infection. In this study, we eva...
O'Brien, Erin M Spiller, Kara L
Published in
Journal of leukocyte biology
Tissue repair is largely regulated by diverse Mϕ populations whose functions are timing- and context-dependent. The early phase of healing is dominated by pro-inflammatory Mϕs, also known as M1, followed by the emergence of a distinct and diverse population that is collectively referred to as M2. The extent of the diversity of the M2 population is ...
Luu, Maik Binder, Kai Hartmann, Sabrina Kespohl, Meike Bazant, Jasmin Romero, Rossana Schütz, Burkhard Steinhoff, Ulrich Visekruna, Alexander
Published in
Journal of leukocyte biology
The NF-κB transcription factor c-Rel plays a crucial role in promoting and regulating immune responses and inflammation. However, the function of c-Rel in modulating the mucosal immune system is poorly understood. T follicular helper (Tfh) cells and IgA production in gut-associated lymphoid tissues (GALT) such as Peyer's patches (PPs) are important...
Yang, Ning Liu, Xuemei Chen, Xu Yu, Si Yang, Wenxiao Liu, Yao
Published in
Journal of leukocyte biology
Mesenchymal stem cell transplantation (MSCT) regulates immune cells, and is a promising therapeutic approach for treating autoimmune diseases. Stem cells from human exfoliated deciduous teeth (SHED) are a unique postnatal stem cell population from the cranial neural crest with high self-renewal, multipotent differentiation, and superior immunomodul...
Dang, Yipu Souchet, Camille Moresi, Fabiana Jeljeli, Mohamed Raquillet, Bruno Nicco, Carole Chouzenoux, Sandrine Lagoutte, Isabelle Marcellin, Louis Batteux, Frederic
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Published in
Journal of leukocyte biology
Trained immunity is a new concept illustrating that innate immune cells are able to undergo a long-term metabolic and epigenetic reprogramming after infection or vaccination, thus displaying either a pro- or an anti-inflammatory phenotype during a sequential unrelated challenge. Innate immune cells such as natural killer (NK) cells and macrophages ...
Wu, Yujiao Yu, Qianying Zhang, Meng Zhou, Yao Su, Xiao Wu, Min Lv, Jiajia Xia, Zhenwei
Published in
Journal of leukocyte biology
Hemin, a substrate of heme oxygenase (HO)-1, induces HO-1 expression on a variety of cells to exert anti-oxidant and anti-inflammatory roles. However, the role of HO-1 in allergic diseases for dendritic cells (DCs) is not fully understood. Here, we report that HO-1 modulates asthmatic airway inflammation by hemin-treated DC-released extracellular v...
Lepzien, Rico Nie, Mu Czarnewski, Paulo Liu, Sang Yu, Meng Ravindran, Avinash Kullberg, Susanna Eklund, Anders Grunewald, Johan Smed-Sörensen, Anna
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Published in
Journal of leukocyte biology
Sarcoidosis is a systemic inflammatory disease mainly affecting the lungs. The hallmark of sarcoidosis are granulomas that are surrounded by activated T cells, likely targeting the disease-inducing antigen. IFNγ-producing Th1 and Th17.1 T cells are elevated in sarcoidosis and associate with disease progression. Monocytes and dendritic cells (DCs) a...
