Scheenstra, Maaike R Martínez-Botía, Patricia Acebes-Huerta, Andrea Brouwer, Rutger W W Caballero-Sánchez, Noemí Gillemans, Nynke De Bleser, Pieter Nota, Benjamin De Cuyper, Iris M Salunkhe, Vishal
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Published in
Journal of leukocyte biology
Dendritic cells (DCs) are key immune modulators and are able to mount immune responses or tolerance. DC differentiation and activation imply a plethora of molecular and cellular responses, including transcriptional changes. PU.1 is a highly expressed transcription factor in DCs and coordinates relevant aspects of DC biology. Due to their role as im...
Parackova, Zuzana Bloomfield, Marketa Klocperk, Adam Sediva, Anna
Published in
Journal of leukocyte biology
From the beginning of 2020, an urgent need to understand the pathophysiology of SARS-CoV-2 disease (COVID-19), much of which is due to dysbalanced immune responses, resonates across the world. COVID-19-associated neutrophilia, increased neutrophil-to-lymphocyte ratio, aberrant neutrophil activation, and infiltration of neutrophils into lungs sugges...
Tomescu, Costin Colon, Krystal Smith, Peter Taylor, Mack Azzoni, Livio Metzger, David S Montaner, Luis J
Published in
Journal of leukocyte biology
Previous literature suggests that acute opioid use results in the functional impairment of the immune response, thereby decreasing resistance to viral infection. Here, we assessed if innate and adaptive immune responses are compromised ex vivo in persons who inject drugs (PWID) and whether long-term injection drug use may impact host susceptibility...
Javmen, Artur Szmacinski, Henryk Lakowicz, Joseph R Toshchakov, Vladimir Y
Published in
Journal of leukocyte biology
TLRs sense a broad range of microbial molecules and initiate antimicrobial immune response. The members of the TLR family use cytoplasmic Toll/interleukin-1R homology (TIR) domain to initiate intracellular signaling. The activated TLRs dimerize their TIRs and recruit adapter proteins to the dimer, through multiple interactions of receptor and adapt...
Morikis, Vasilios A Masadeh, Eman Simon, Scott I
Published in
Journal of leukocyte biology
Recruitment of leukocytes to sites of acute inflammation is guided by spatial and temporal cues that ensure appropriate cell numbers infiltrate the tissue at precise locations to protect it from infection and initiate repair. On inflamed endothelium, neutrophil rolling via selectins elicits cytosolic calcium release from endoplasmic reticulum (ER)-...
Ng, Hang Pong Jennings, Scott Wellems, Dianne Sun, Fei Xu, Jie Nauseef, William M Wang, Guoshun
Published in
Journal of leukocyte biology
Persistent neutrophilic inflammation is a hallmark of cystic fibrosis (CF). However, the mechanisms underlying this outstanding pathology remain incompletely understood. Here, we report that CFTR in myeloid immune cells plays a pivotal role in control of neutrophilic inflammation. Myeloid CFTR-Knockout (Mye-Cftr-/-) mice and congenic wild-type (WT)...
Shi, Ting Li, Tiantian Jiang, Xinru Jiang, Xin Zhang, Qingwen Wang, Yuli Zhang, Yaxing Wang, Lixin Qin, Xiangyang Zhang, Weidong
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Published in
Journal of leukocyte biology
Sepsis was redefined as life-threatening organ dysfunction caused by a dysregulated host response to infection in 2016. One of its most common causes is Staphylococcus aureus, especially methicillin-resistant Staphylococcus aureus (MRSA), which leads to a significant increase in morbidity and mortality. Therefore, innovative and effective approache...
Maxwell, Anthony J Ding, Jiahui You, Yuan Dong, Zhong Chehade, Hussein Alvero, Ayesha Mor, Yechiel Draghici, Sorin Mor, Gil
Published in
Journal of leukocyte biology
The SARS-CoV-2 pandemic has led to hundreds of thousands of deaths and billions of dollars in economic damage. The immune response elicited from this virus is poorly understood. An alarming number of cases have arisen where COVID-19 patients develop complications on top of the symptoms already associated with SARS, such as thrombosis, injuries of v...
Cooper, Kelley N Bagaitkar, Juhi
Published in
Journal of leukocyte biology
Discussion on targeting LXR and PPAR agonists as therapeutic alternatives to ustekinumab therapy in LAD-1. ©2020 Society for Leukocyte Biology.
Hassani, Marwan Leijte, Guus Bruse, Niklas Kox, Matthijs Pickkers, Peter Vrisekoop, Nienke Koenderman, Leo
Published in
Journal of leukocyte biology
Acute infection is characterized by eosinopenia. However, the underlying mechanism(s) are poorly understood and it is unclear whether decreased mobilization/production of eosinophils in the bone marrow (BM) and/or increased homing to the tissues play a role. The objective of this study was to investigate the differentiation and activation status of...
