Frederick, Ariel K Thompson, Sidney L Vakharia, Zahra M Cherney, Melisa M Lei, Haotian Evenson, Garrett Bowler, Bruce E
Published in
Journal of inorganic biochemistry
Naturally-occurring variants of human cytochrome c (Cytc) that induce thrombocytopenia IV occur within Ω-loop C (residues 40-57). These variants enhance the peroxidase activity of human Cytc apparently by facilitating access to the heme by destabilizing Ω-loops C and D (residues 70-85). Given the importance of peroxidase activity in the early stage...
Rosa, Nathália Magalhães P Ferreira, Frederico Henrique do C Farrell, Nicholas P Costa, Luiz Antônio S
Published in
Journal of inorganic biochemistry
An impressive class of formally substitution-inert polynuclear platinum complexes known as Substitution-inert Polynuclear Platinum (II) Complexes (SI-PPCs) present an attractive approach for medicinal inorganic chemistry through high-affinity non-covalent interactions with biomolecules, such as DNA and Glycosaminoglycans (GAGs). This interaction oc...
Cook, Thomas C Stenehjem, Eric D Ainsworth, Jasper Stack, T Daniel P
Published in
Journal of inorganic biochemistry
A dearth of discrete immobilized metal complexes exist that electrocatalytically oxidize methanol. Reported here is the covalent immobilization of a tris(2-pyridylmethyl)amine ruthenium complex [RuII(Cl)(DMSO)(ethynyl-TPA)]+ (ethynyl-TPA = (5-ethynyl-2-pyridylmethyl)bis(2-pyridylmethyl)amine) to a glassy carbon (GC) electrode through a CuI catalyze...
Pósa, Vivien Hajdu, Bálint Tóth, Gábor Dömötör, Orsolya Kowol, Christian R Keppler, Bernhard K Spengler, Gabriella Gyurcsik, Béla Enyedy, Éva A
Published in
Journal of inorganic biochemistry
Thiosemicarbazones are promising candidates for anticancer therapy and their mechanism of action is often linked to their metal chelating ability. In this study, five (thio)semicarbazones with different donor sets (NNS, NNO, ONS, ONO) were selected and their behaviour in aqueous solution, the stability of their copper(II) complexes in addition to t...
Liu, Qiong Wu, YingKai Li, Ju Liu, Ertao Tian, Fan Zhao, Huiping Chen, Rong
Published in
Journal of inorganic biochemistry
Ag-decorated ZnO nanorods with different Ag contents were prepared by deposition-precipitation method, which demonstrated enhanced inhibition ability for the common pathogen, especially exhibited excellent antibacterial effects on clinical drug resistant bacteria. Moreover, Ag-decorated ZnO nanorods presented much lower cytotoxicity to HEK293 cell ...
Terner, James Thomas, Kolle E Vazquez-Lima, Hugo Ghosh, Abhik
Published in
Journal of inorganic biochemistry
Soret-excited resonance Raman spectra (λex 413.1 nm) were acquired for manganese(III) and gold(III) tris(pentafluorophenyl)corrole, each as four different isotopomeric samples: natural abundance, fully pyrrole-15N-substituted, fully meso-13C-substituted, and fully pyrrole-15N-meso-13C-substituted. The spectra were modeled with density functional th...
Matsumura, Hirotoshi Faponle, Abayomi S Hagedoorn, Peter-Leon Tosha, Takehiko de Visser, Sam P Moënne-Loccoz, Pierre
Published in
Journal of inorganic biochemistry
Steady-state kinetics of cytochrome-c dependent denitrifying NO reductases (cNORs) show evidence of substrate inhibition at NO concentrations higher than 10 μM, but the mechanism of inhibition remains unclear. Here, we present low-temperature FTIR photolysis experiments carried out on the NO complex formed by addition of NO to the oxidized cNORs. A...
Guan, Ye Londoño-Salazar, Jennifer Pei, Zheng Powell, Douglas R Shao, Yihan Richter-Addo, George B
Published in
Journal of inorganic biochemistry
Hydroxylamine (NH2OH) and its N-substituted derivatives (RNHOH) are important biological intermediates in the global N cycle. Heme plays a central role in the binding and activation of these hydroxylamines. We report the crystal structures of N-hydroxyamphetamine (AmphNHOH) in complex with Fe and Co heme models. We demonstrate a previously unrecogn...
Figueroa-DePaz, Yeshenia Resendiz-Acevedo, Karen Dávila-Manzanilla, Silvia Graciela García-Ramos, Juan Carlos Ortiz-Frade, Luis Serment-Guerrero, Jorge Ruiz-Azuara, Lena
Published in
Journal of inorganic biochemistry
Casiopeinas are a family of mixed chelate copper(II) complexes with antiproliferative and antineoplastic activities, results that have positioned them as an alternative for cancer treatment. Because DNA is one of their principal targets, it is of our interest to find out the effect of substituents on the diiamine ligands over mode of interaction. T...
Dimitrijević Stojanović, Milica N Franich, Andjela A Jurišević, Milena M Gajović, Nevena M Arsenijević, Nebojša N Jovanović, Ivan P Stojanović, Bojan S Mitrović, Slobodanka Lj Kljun, Jakob Rajković, Snežana
...
Published in
Journal of inorganic biochemistry
Four Pt(II) complexes of the general formula [Pt(L)(5,6-epoxy-1,10-phen)], where L is an anion of either malonic acid (mal, Pt1), 2-methylmalonic acid (Me-mal, Pt2), 2,2-dimethylmalonic acid (Me2-mal, Pt3) or 1,1-cyclobutanedicarboxylic acid (CBDCA, Pt4) and 5,6-epoxy-1,10-phen is 5,6-epoxy-5,6-dihydro-1,10-phenanthroline, were synthesized and char...
