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Real-time assessment of video images for esophageal squamous cell carcinoma invasion depth using artificial intelligence...

Published in Journal of gastroenterology

Although optimal treatment of superficial esophageal squamous cell carcinoma (SCC) requires accurate evaluation of cancer invasion depth, the current process is rather subjective and may vary by observer. We, therefore, aimed to develop an AI system to calculate cancer invasion depth. We gathered and selected 23,977 images (6857 WLI and 17,120 NBI/...

Solving the questions regarding 5-aminosalitylate formulation in the treatment of ulcerative colitis.

Published in Journal of gastroenterology

5-aminosalicylate is a fundamental treatment for patients with ulcerative colitis with mild-to-moderate disease; however, evidence for 5-aminosalicylate treatment is unclear in some situations. This review discusses the clinical guidelines and previous studies, and highlights the following points: (1) Although rectal 5-aminosalicylate is effective ...

Correction to: Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradica...

Published in Journal of gastroenterology

In the original publication of the article, the article title was published with typo. The word "eradiation" should be "eradication" in the article title and keywords.

Effects of vedolizumab in Japanese patients with Crohn's disease: a prospective, multicenter, randomized, placebo-contro...

Published in Journal of gastroenterology

Vedolizumab is a gut-selective humanized antibody that binds the α4β7 integrin. We evaluated efficacy and safety of vedolizumab in Japanese patients with moderate-to-severe Crohn's disease (CD). In this Phase 3, double-blind study (NCT02038920), 157 patients were randomized to receive intravenous vedolizumab 300 mg (n = 79) or placebo (n = 78) at W...

Abdominal obesity increases risk for esophageal cancer: a nationwide population-based cohort study of South Korea.

Published in Journal of gastroenterology

The relationship between overall obesity, as measured by body mass index (BMI) and risk of esophageal squamous cell carcinoma (ESCC) has been reported to show a negative correlation. However, the relationship of ESCC, which accounts for around 90% of esophageal cancers in South Korea, with abdominal obesity, as measured by waist circumference (WC),...

Continuous regional arterial infusion versus intravenous administration of the protease inhibitor nafamostat mesilate fo...

Published in Journal of gastroenterology

Continuous regional arterial infusion (CRAI) of protease inhibitor nafamostat mesilate (NM) is used in the context of predicted severe acute pancreatitis (SAP) to prevent the development of pancreatic necrosis. Although this therapy is well known in Japan, its efficacy and safety remain unclear. This investigator-initiated and -driven, multicenter,...

The protective effect of betacellulin against acute pancreatitis is ERBB4 dependent.

Published in Journal of gastroenterology

The EGFR ligand betacellulin (BTC) has been previously shown to protect mice against experimentally induced acute pancreatitis (AP). BTC binds both autonomous ERBB receptors EGFR and ERBB4. In this study, we evaluated the mechanism underlying the protection from AP-associated inflammation in detail. AP was induced with cerulein or L-arginine and in...

Emerging therapies for PBC.

Published in Journal of gastroenterology

Primary biliary cholangitis is an uncommon cholestatic liver disease predominantly affecting middle-aged women. Left untreated, there is a high risk of progression to end-stage liver disease. Few treatment options exist. To date, ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) are the only medical therapies approved for use, other than sympt...

Is metabolic syndrome responsible for the progression from NAFLD to NASH in non-obese patients?

Published in Journal of gastroenterology