Kita, Toshihiro Ashizuka, Sinya Ohmiya, Naoki Yamamoto, Takayuki Kanai, Takanori Motoya, Satoshi Hirai, Fumihito Nakase, Hiroshi Moriyama, Tomohiko Nakamura, Masanao
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Published in
Journal of gastroenterology
Adrenomedullin (AM) is a bioactive peptide having many pleiotropic effects, including mucosal healing and immunomodulation. AM has shown beneficial effects in rodent models and in preliminary study for patients with ulcerative colitis (UC). We performed a clinical trial to investigate the efficacy and safety of AM in patients with UC. This was a mu...
Lenoir, Marion Del Carmen, Silvina Cortes-Perez, Naima G Lozano-Ojalvo, Daniel Muñoz-Provencio, Diego Chain, Florian Langella, Philippe de Moreno de LeBlanc, Alejandra LeBlanc, Jean Guy Bermúdez-Humarán, Luis G
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Published in
Journal of gastroenterology
This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s00535-015-1158-9 .
Maruki, Yuta Morizane, Chigusa Arai, Yasuhito Ikeda, Masafumi Ueno, Makoto Ioka, Tatsuya Naganuma, Atsushi Furukawa, Masayuki Mizuno, Nobumasa Uwagawa, Tadashi
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Published in
Journal of gastroenterology
Fibroblast growth factor receptor 2 (FGFR2) rearrangement is expected to be a novel therapeutic target in advanced/recurrent biliary tract cancer (BTC). However, efficient detection and the exact frequency of FGFR2 rearrangements among patients with advanced/recurrent BTC have not been determined, and the clinical characteristics of FGFR2 rearrange...
Li, Darrick K Haffar, Samir Horibe, Masayasu Homsi, Haya A Zukerberg, Lawrence Murad, Mohammad H Visrodia, Kavel H Gala, Manish Katzka, David A Bazerbachi, Fateh
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Published in
Journal of gastroenterology
Verrucous esophageal carcinoma (VEC) is a rare malignancy that presents a diagnostic challenge. We aim to characterize the clinical and genomic features, tumor behavior, and treatment outcomes of VEC to guide clinical practice. We performed a systematic review of the literature and identified additional cases from Massachusetts General Hospital rec...
Takabayashi, Kaoru Hosoe, Naoki Kato, Motohiko Hayashi, Yukie Nanki, Kosaku Fukuhara, Kayoko Mikami, Yohei Mizuno, Shinta Sujino, Tomohisa Mutaguchi, Makoto
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Published in
Journal of gastroenterology
Small bowel lesions of Crohn's disease (CD) are known to be associated with a poor prognosis; however, endoscopic healing leads to favorable patients' outcome. The aim of this study was to clarify the clinical impact of assessing deep small bowel lesions (DSB) using balloon-assisted enteroscopy (BAE) on CD patients in clinical remission. From Janua...
Miki, Daiki Akita, Tomoyuki Kurisu, Akemi Kawaoka, Tomokazu Nakajima, Tomoaki Hige, Shuhei Karino, Yoshiyasu Toyoda, Hidenori Kumada, Takashi Tsuge, Masataka
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Published in
Journal of gastroenterology
Even though both interferon (IFN)-based and direct-acting antiviral (DAA) therapies against hepatitis C virus (HCV) reduce the risk of hepatocellular carcinoma (HCC), post-sustained virological response (SVR) patients remain at elevated risk of HCC. A total of 4620 patients who achieved SVR were enrolled in this retrospective cohort study. After ex...
Dunbar, Ellyn Greer, Phil J Melhem, Nadine Alkaade, Samer Amann, Stephen T Brand, Randall Coté, Gregory A Forsmark, Christopher E Gardner, Timothy B Gelrud, Andres
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Published in
Journal of gastroenterology
Pain is the most debilitating symptom of recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP) and often requires chronic opioids or total pancreatectomy with islet autotransplantation to manage. Pain is a complex experience that can be exacerbated by depression and vice versa. Our aim was to test the hypothesis that depression-associate...
Shida, Dai Inoue, Manabu Tanabe, Taro Moritani, Konosuke Tsukamoto, Shunsuke Yamauchi, Shinichi Sugihara, Kenichi Kanemitsu, Yukihide
Published in
Journal of gastroenterology
Previous studies investigating the impact of tumor location on colorectal cancer prognosis only compared two groups by location, e.g., 'right-sided colon vs. left-sided colon,' 'colon vs. rectum,' and 'right-sided (right-sided colon) vs. left-sided (left-sided colon and rectum).' This nationwide multicenter retrospective study aimed to clarify the ...
Shimamoto, Yusaku Ishihara, Ryu Kato, Yusuke Shoji, Ayaka Inoue, Takahiro Matsueda, Katsunori Miyake, Muneaki Waki, Kotaro Kono, Mitsuhiro Fukuda, Hiromu
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Published in
Journal of gastroenterology
Although optimal treatment of superficial esophageal squamous cell carcinoma (SCC) requires accurate evaluation of cancer invasion depth, the current process is rather subjective and may vary by observer. We, therefore, aimed to develop an AI system to calculate cancer invasion depth. We gathered and selected 23,977 images (6857 WLI and 17,120 NBI/...
Naganuma, Makoto
Published in
Journal of gastroenterology
5-aminosalicylate is a fundamental treatment for patients with ulcerative colitis with mild-to-moderate disease; however, evidence for 5-aminosalicylate treatment is unclear in some situations. This review discusses the clinical guidelines and previous studies, and highlights the following points: (1) Although rectal 5-aminosalicylate is effective ...
